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Gray matter abnormalities associated with duration of untreated psychosis.
Schizophr Res 2006; 83(2-3):145-53SR

Abstract

PURPOSE

A long duration of untreated psychosis (DUP) is associated with relatively poor clinical and social outcomes. In order to identify whether an anatomically mediated mechanism may give rise to poorer outcomes, it is important to identify whether a long DUP is associated with greater brain structural abnormalities.

METHOD

81 patients with first-episode psychosis (schizophrenia, affective, and other psychoses) were scanned using high resolution Magnetic Resonance Imaging. DUP was defined as the number of days between first onset of psychotic symptoms and first contact with mental health services. High-resolution MRI images and voxel-based methods of image analysis were used to investigate brain structure in these patients.

RESULTS

Longer DUP was associated with gray matter reductions in left middle and inferior temporal, left occipital and left fusiform cortices, and with gray matter excess of the left basal ganglia. All findings remained significant when co-varying for exposure to antipsychotic treatment.

CONCLUSIONS

Temporal gray matter reductions are more marked in patients with a long DUP. This could reflect a progressive pathological process that is active prior to treatment. Alternatively, these abnormalities could be associated with a more insidious onset of illness and a later presentation to services.

Authors+Show Affiliations

Kings College London Institute of Psychiatry, PO63, Division of Psychological Medicine, King's College London, London SE5 8AF, United Kingdom. j.lappin@iop.kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16448803

Citation

Lappin, Julia M., et al. "Gray Matter Abnormalities Associated With Duration of Untreated Psychosis." Schizophrenia Research, vol. 83, no. 2-3, 2006, pp. 145-53.
Lappin JM, Morgan K, Morgan C, et al. Gray matter abnormalities associated with duration of untreated psychosis. Schizophr Res. 2006;83(2-3):145-53.
Lappin, J. M., Morgan, K., Morgan, C., Hutchison, G., Chitnis, X., Suckling, J., ... Dazzan, P. (2006). Gray matter abnormalities associated with duration of untreated psychosis. Schizophrenia Research, 83(2-3), pp. 145-53.
Lappin JM, et al. Gray Matter Abnormalities Associated With Duration of Untreated Psychosis. Schizophr Res. 2006;83(2-3):145-53. PubMed PMID: 16448803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gray matter abnormalities associated with duration of untreated psychosis. AU - Lappin,Julia M, AU - Morgan,Kevin, AU - Morgan,Craig, AU - Hutchison,Gerard, AU - Chitnis,Xavier, AU - Suckling,John, AU - Fearon,Paul, AU - McGuire,Philip K, AU - Jones,Peter B, AU - Leff,Julian, AU - Murray,Robin M, AU - Dazzan,Paola, Y1 - 2006/01/31/ PY - 2005/07/29/received PY - 2005/10/28/revised PY - 2005/11/14/accepted PY - 2006/2/2/pubmed PY - 2006/9/20/medline PY - 2006/2/2/entrez SP - 145 EP - 53 JF - Schizophrenia research JO - Schizophr. Res. VL - 83 IS - 2-3 N2 - PURPOSE: A long duration of untreated psychosis (DUP) is associated with relatively poor clinical and social outcomes. In order to identify whether an anatomically mediated mechanism may give rise to poorer outcomes, it is important to identify whether a long DUP is associated with greater brain structural abnormalities. METHOD: 81 patients with first-episode psychosis (schizophrenia, affective, and other psychoses) were scanned using high resolution Magnetic Resonance Imaging. DUP was defined as the number of days between first onset of psychotic symptoms and first contact with mental health services. High-resolution MRI images and voxel-based methods of image analysis were used to investigate brain structure in these patients. RESULTS: Longer DUP was associated with gray matter reductions in left middle and inferior temporal, left occipital and left fusiform cortices, and with gray matter excess of the left basal ganglia. All findings remained significant when co-varying for exposure to antipsychotic treatment. CONCLUSIONS: Temporal gray matter reductions are more marked in patients with a long DUP. This could reflect a progressive pathological process that is active prior to treatment. Alternatively, these abnormalities could be associated with a more insidious onset of illness and a later presentation to services. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/16448803/Gray_matter_abnormalities_associated_with_duration_of_untreated_psychosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(05)00504-9 DB - PRIME DP - Unbound Medicine ER -