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The relation of blood pressure to coronary heart mortality in different age groups varies by ethnicity.
Am J Hypertens. 2006 Feb; 19(2):179-83.AJ

Abstract

BACKGROUND

The relative importance of pulse pressure, mean arterial pressure, systolic blood pressure (SBP), and diastolic blood pressure (DBP) as predictors of coronary heart disease (CHD) have been shown to change with aging in individuals of white ethnicity, but few published data exist for those of African American ethnicity.

METHODS

To assess the role of ethnicity in this relationship we compared the association of BP indices to CHD mortality (from a pooled database of eight prospective cohorts, n = 29829, follow-up 13.8 +/- 7.9 years, 1912 events) in the four age groups (30 to 39, 40 to 49, 50 to 59, and > or = 60 years) by the decrease in the -2 log likelihood in Cox regression analyses of subjects who were not receiving antihypertensive drug therapy at baseline.

RESULTS

All BP indices were significant (P < .05) for all age groups in models containing a single BP index. In white subjects, the best predictor of CHD mortality was DBP for persons 30 to 39 years of age, whereas SBP was the best predictor for persons 40 to 49, 50 to 59 and > or = 60 years of age. In African American subjects, SBP was the best predictor in all age groups. When considered jointly, DBP, but not SBP, was significantly associated with CHD mortality in white subjects 30 to 39 years of age. Only SBP was significant in white subjects 40 to 49, 50 to 59, and > or = 60 years of age. In African Americans, SBP, but not DBP, was associated with CHD mortality in all four age groups when both were in the model.

CONCLUSION

In African American subjects, SBP was found to be a better predictor of CHD mortality than DBP or pulse pressure. In white subjects, there was a shift in importance from DBP to SBP as predictors of CHD mortality from the 30 to 39-year age group to the older groups.

Authors+Show Affiliations

Department of Medicine, Columbia University, New York, New York 10032, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16448889

Citation

Paultre, Furcy, and Lori Mosca. "The Relation of Blood Pressure to Coronary Heart Mortality in Different Age Groups Varies By Ethnicity." American Journal of Hypertension, vol. 19, no. 2, 2006, pp. 179-83.
Paultre F, Mosca L. The relation of blood pressure to coronary heart mortality in different age groups varies by ethnicity. Am J Hypertens. 2006;19(2):179-83.
Paultre, F., & Mosca, L. (2006). The relation of blood pressure to coronary heart mortality in different age groups varies by ethnicity. American Journal of Hypertension, 19(2), 179-83.
Paultre F, Mosca L. The Relation of Blood Pressure to Coronary Heart Mortality in Different Age Groups Varies By Ethnicity. Am J Hypertens. 2006;19(2):179-83. PubMed PMID: 16448889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation of blood pressure to coronary heart mortality in different age groups varies by ethnicity. AU - Paultre,Furcy, AU - Mosca,Lori, PY - 2005/03/03/received PY - 2005/07/11/revised PY - 2005/07/16/accepted PY - 2006/2/2/pubmed PY - 2006/5/26/medline PY - 2006/2/2/entrez SP - 179 EP - 83 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 19 IS - 2 N2 - BACKGROUND: The relative importance of pulse pressure, mean arterial pressure, systolic blood pressure (SBP), and diastolic blood pressure (DBP) as predictors of coronary heart disease (CHD) have been shown to change with aging in individuals of white ethnicity, but few published data exist for those of African American ethnicity. METHODS: To assess the role of ethnicity in this relationship we compared the association of BP indices to CHD mortality (from a pooled database of eight prospective cohorts, n = 29829, follow-up 13.8 +/- 7.9 years, 1912 events) in the four age groups (30 to 39, 40 to 49, 50 to 59, and > or = 60 years) by the decrease in the -2 log likelihood in Cox regression analyses of subjects who were not receiving antihypertensive drug therapy at baseline. RESULTS: All BP indices were significant (P < .05) for all age groups in models containing a single BP index. In white subjects, the best predictor of CHD mortality was DBP for persons 30 to 39 years of age, whereas SBP was the best predictor for persons 40 to 49, 50 to 59 and > or = 60 years of age. In African American subjects, SBP was the best predictor in all age groups. When considered jointly, DBP, but not SBP, was significantly associated with CHD mortality in white subjects 30 to 39 years of age. Only SBP was significant in white subjects 40 to 49, 50 to 59, and > or = 60 years of age. In African Americans, SBP, but not DBP, was associated with CHD mortality in all four age groups when both were in the model. CONCLUSION: In African American subjects, SBP was found to be a better predictor of CHD mortality than DBP or pulse pressure. In white subjects, there was a shift in importance from DBP to SBP as predictors of CHD mortality from the 30 to 39-year age group to the older groups. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/16448889/The_relation_of_blood_pressure_to_coronary_heart_mortality_in_different_age_groups_varies_by_ethnicity_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2005.07.020 DB - PRIME DP - Unbound Medicine ER -