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Black cohosh and St. John's wort for climacteric complaints: a randomized trial.
Obstet Gynecol. 2006 Feb; 107(2 Pt 1):247-55.OG

Abstract

OBJECTIVE

To investigate the efficacy of the fixed combination of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) extracts in women with climacteric complaints with a pronounced psychological component.

METHODS

In this double-blind randomized placebo-control study, 301 women experiencing climacteric complaints with psychological symptoms were treated with ethanolic St. John's wort extract and isopropanolic black cohosh extract or a matched placebo for 16 weeks. Climacteric complaints were evaluated by means of the Menopause Rating Scale mean score, and psychological complaints were evaluated using the Hamilton Depression Rating Scale sum score.

RESULTS

The mean (+/- standard deviation) Menopause Rating Scale score decreased 50% (0.46 +/- 0.13 to 0.23 +/- 0.13) in the treatment group and 19.6% (0.46 +/- 0.14 to 0.37 +/- 0.15) in the placebo group. The Hamilton Depression Rating Scale total score decreased 41.8% in the treatment group (18.9 +/- 2.2 to 11.0 +/- 3.8 points), and 12.7% in the placebo group (18.9 +/- 2.1 to 16.5 +/- 4.3). The treatment was significantly (P < .001) superior to placebo in both measures. There were no relevant group differences regarding adverse events, laboratory values, or tolerability.

CONCLUSION

This fixed combination of black cohosh and St. John's wort is superior to placebo in alleviating climacteric complaints, including the related psychological component.

LEVEL OF EVIDENCE

I.

Authors+Show Affiliations

Clinic of Psychiatry, Clinic of Gynecology and St. Gertrauden-Krankenhaus, University Hospital Charité of the Humboldt-University, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16449108

Citation

Uebelhack, Ralf, et al. "Black Cohosh and St. John's Wort for Climacteric Complaints: a Randomized Trial." Obstetrics and Gynecology, vol. 107, no. 2 Pt 1, 2006, pp. 247-55.
Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol. 2006;107(2 Pt 1):247-55.
Uebelhack, R., Blohmer, J. U., Graubaum, H. J., Busch, R., Gruenwald, J., & Wernecke, K. D. (2006). Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstetrics and Gynecology, 107(2 Pt 1), 247-55.
Uebelhack R, et al. Black Cohosh and St. John's Wort for Climacteric Complaints: a Randomized Trial. Obstet Gynecol. 2006;107(2 Pt 1):247-55. PubMed PMID: 16449108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Black cohosh and St. John's wort for climacteric complaints: a randomized trial. AU - Uebelhack,Ralf, AU - Blohmer,Jens-Uwe, AU - Graubaum,Hans-Joachim, AU - Busch,Regina, AU - Gruenwald,Joerg, AU - Wernecke,Klaus-Dieter, PY - 2006/2/2/pubmed PY - 2006/4/6/medline PY - 2006/2/2/entrez SP - 247 EP - 55 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 107 IS - 2 Pt 1 N2 - OBJECTIVE: To investigate the efficacy of the fixed combination of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) extracts in women with climacteric complaints with a pronounced psychological component. METHODS: In this double-blind randomized placebo-control study, 301 women experiencing climacteric complaints with psychological symptoms were treated with ethanolic St. John's wort extract and isopropanolic black cohosh extract or a matched placebo for 16 weeks. Climacteric complaints were evaluated by means of the Menopause Rating Scale mean score, and psychological complaints were evaluated using the Hamilton Depression Rating Scale sum score. RESULTS: The mean (+/- standard deviation) Menopause Rating Scale score decreased 50% (0.46 +/- 0.13 to 0.23 +/- 0.13) in the treatment group and 19.6% (0.46 +/- 0.14 to 0.37 +/- 0.15) in the placebo group. The Hamilton Depression Rating Scale total score decreased 41.8% in the treatment group (18.9 +/- 2.2 to 11.0 +/- 3.8 points), and 12.7% in the placebo group (18.9 +/- 2.1 to 16.5 +/- 4.3). The treatment was significantly (P < .001) superior to placebo in both measures. There were no relevant group differences regarding adverse events, laboratory values, or tolerability. CONCLUSION: This fixed combination of black cohosh and St. John's wort is superior to placebo in alleviating climacteric complaints, including the related psychological component. LEVEL OF EVIDENCE: I. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/16449108/Black_cohosh_and_St__John's_wort_for_climacteric_complaints:_a_randomized_trial_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=16449108.ui DB - PRIME DP - Unbound Medicine ER -