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Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy.
Psychosom Med 2006 Jan-Feb; 68(1):143-51PM

Abstract

OBJECTIVE

Human Immunodeficiency Virus (HIV)-positive individuals treated with highly active antiretroviral therapy (HAART) may experience psychological burdens and negative mood states, which could impair their ability to derive maximum benefits from their medical treatment. We tested whether a cognitive behavioral stress management (CBSM) intervention in combination with antiretroviral medication adherence training (MAT) from a clinical pharmacist influences HIV viral load more than MAT alone.

METHODS

HIV-positive men who have sex with men were randomized to either a 10-week CBSM + MAT intervention (n = 76) or a MAT-Only condition (n = 54). Data were collected at baseline immediately following the 10-week intervention period, at 9 months postrandomization, and at 15 months postrandomization.

RESULTS

We found no differences in HIV viral load among the 130 men randomized. However, in the 101 men with detectable viral load at baseline, those randomized to CBSM + MAT (n = 61) displayed reductions of 0.56 log10 units in HIV viral load over a 15-month period after controlling for medication adherence. Men in the MAT-Only condition (n = 40) showed no change. Decreases in depressed mood during the intervention period explained the effect of CBSM + MAT on HIV viral load reduction over the 15 months.

CONCLUSIONS

A time-limited CBSM + MAT intervention that modulates depressed mood may enhance the effects of HAART on suppression of HIV viral load in HIV+ men with detectable plasma levels.

Authors+Show Affiliations

Department of Psychology, University of Miami, Coral Gables, FL, USA. Mantoni@miami.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16449425

Citation

Antoni, Michael H., et al. "Randomized Clinical Trial of Cognitive Behavioral Stress Management On Human Immunodeficiency Virus Viral Load in Gay Men Treated With Highly Active Antiretroviral Therapy." Psychosomatic Medicine, vol. 68, no. 1, 2006, pp. 143-51.
Antoni MH, Carrico AW, Durán RE, et al. Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy. Psychosom Med. 2006;68(1):143-51.
Antoni, M. H., Carrico, A. W., Durán, R. E., Spitzer, S., Penedo, F., Ironson, G., ... Schneiderman, N. (2006). Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy. Psychosomatic Medicine, 68(1), pp. 143-51.
Antoni MH, et al. Randomized Clinical Trial of Cognitive Behavioral Stress Management On Human Immunodeficiency Virus Viral Load in Gay Men Treated With Highly Active Antiretroviral Therapy. Psychosom Med. 2006;68(1):143-51. PubMed PMID: 16449425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy. AU - Antoni,Michael H, AU - Carrico,Adam W, AU - Durán,Ron E, AU - Spitzer,Susan, AU - Penedo,Frank, AU - Ironson,Gail, AU - Fletcher,Mary Ann, AU - Klimas,Nancy, AU - Schneiderman,Neil, PY - 2006/2/2/pubmed PY - 2006/7/19/medline PY - 2006/2/2/entrez SP - 143 EP - 51 JF - Psychosomatic medicine JO - Psychosom Med VL - 68 IS - 1 N2 - OBJECTIVE: Human Immunodeficiency Virus (HIV)-positive individuals treated with highly active antiretroviral therapy (HAART) may experience psychological burdens and negative mood states, which could impair their ability to derive maximum benefits from their medical treatment. We tested whether a cognitive behavioral stress management (CBSM) intervention in combination with antiretroviral medication adherence training (MAT) from a clinical pharmacist influences HIV viral load more than MAT alone. METHODS: HIV-positive men who have sex with men were randomized to either a 10-week CBSM + MAT intervention (n = 76) or a MAT-Only condition (n = 54). Data were collected at baseline immediately following the 10-week intervention period, at 9 months postrandomization, and at 15 months postrandomization. RESULTS: We found no differences in HIV viral load among the 130 men randomized. However, in the 101 men with detectable viral load at baseline, those randomized to CBSM + MAT (n = 61) displayed reductions of 0.56 log10 units in HIV viral load over a 15-month period after controlling for medication adherence. Men in the MAT-Only condition (n = 40) showed no change. Decreases in depressed mood during the intervention period explained the effect of CBSM + MAT on HIV viral load reduction over the 15 months. CONCLUSIONS: A time-limited CBSM + MAT intervention that modulates depressed mood may enhance the effects of HAART on suppression of HIV viral load in HIV+ men with detectable plasma levels. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/16449425/Randomized_clinical_trial_of_cognitive_behavioral_stress_management_on_human_immunodeficiency_virus_viral_load_in_gay_men_treated_with_highly_active_antiretroviral_therapy_ L2 - http://Insights.ovid.com/pubmed?pmid=16449425 DB - PRIME DP - Unbound Medicine ER -