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Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis.
Med Sci Monit. 2006 Feb; 12(2):CR55-62.MS

Abstract

BACKGROUND

Among the non-classic cardiovascular disease risk factors in end-stage renal disease patients on chronic hemodialysis (HD), plasma fibrinogen, D-dimer, and von Willebrand factor (vWf) levels are potential markers of cardiovascular morbidity. We designed this case-control study to investigate their validity and any differences between them.

MATERIAL/METHODS

Twenty-five HD patients (18 males, mean age: 63, range: 52-69 years) comprised the group with prevalent cardiovascular disease (CVD) and 50 HD patients (35 males, mean age: 62, range: 40-77 years) with non-evident cardiovascular disease history constituted the second study group. Twenty-five healthy non-smoking volunteers served as controls for comparison with the study groups.

RESULTS

Patients with CVD had significantly higher concentrations of plasma fibrinogen, D-dimer, and vWf than patients without incident CVD. All three parameters correlated positively with cardiovascular morbidity, i.e. fibrinogen (r=0.378, P<0.001), logDD (r=0.70, P<0.001), vWf (r=0.214, P<0.001), and logCRP (r=0.704, P<0.001). Among them, D-dimer exhibited the characteristics most coherent with CVD. The age- and sex-adjusted odds ratio (OR) of D-dimer for the presence of CVD was 2.0, which did not change appreciably when adjustments for several pathophysiological clusters of variables were made, except for a marginal reduction in OR following adjustment for markers of inflammation.

CONCLUSIONS

Among the coagulation molecules studied, plasma D-dimer levels exhibited the characteristics most coherent with associated CVD and were found to be strongly and independently associated with the prevalence of CVD in HD patients.

Authors+Show Affiliations

Department of Nephrology, Serres General Hospital, Serres, Greece. kirmizis@med.auth.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16449948

Citation

Kirmizis, Dimitrios, et al. "Validity of Plasma Fibrinogen, D-dimer, and the Von Willebrand Factor as Markers of Cardiovascular Morbidity in Patients On Chronic Hemodialysis." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 12, no. 2, 2006, pp. CR55-62.
Kirmizis D, Tsiandoulas A, Pangalou M, et al. Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis. Med Sci Monit. 2006;12(2):CR55-62.
Kirmizis, D., Tsiandoulas, A., Pangalou, M., Koutoupa, E., Rozi, P., Protopappa, M., & Barboutis, K. (2006). Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 12(2), CR55-62.
Kirmizis D, et al. Validity of Plasma Fibrinogen, D-dimer, and the Von Willebrand Factor as Markers of Cardiovascular Morbidity in Patients On Chronic Hemodialysis. Med Sci Monit. 2006;12(2):CR55-62. PubMed PMID: 16449948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis. AU - Kirmizis,Dimitrios, AU - Tsiandoulas,Apostolos, AU - Pangalou,Maria, AU - Koutoupa,Evangelia, AU - Rozi,Paraskevi, AU - Protopappa,Maria, AU - Barboutis,Konstantinos, Y1 - 2006/01/26/ PY - 2005/08/01/received PY - 2005/10/06/accepted PY - 2006/2/2/pubmed PY - 2006/4/11/medline PY - 2006/2/2/entrez SP - CR55 EP - 62 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 12 IS - 2 N2 - BACKGROUND: Among the non-classic cardiovascular disease risk factors in end-stage renal disease patients on chronic hemodialysis (HD), plasma fibrinogen, D-dimer, and von Willebrand factor (vWf) levels are potential markers of cardiovascular morbidity. We designed this case-control study to investigate their validity and any differences between them. MATERIAL/METHODS: Twenty-five HD patients (18 males, mean age: 63, range: 52-69 years) comprised the group with prevalent cardiovascular disease (CVD) and 50 HD patients (35 males, mean age: 62, range: 40-77 years) with non-evident cardiovascular disease history constituted the second study group. Twenty-five healthy non-smoking volunteers served as controls for comparison with the study groups. RESULTS: Patients with CVD had significantly higher concentrations of plasma fibrinogen, D-dimer, and vWf than patients without incident CVD. All three parameters correlated positively with cardiovascular morbidity, i.e. fibrinogen (r=0.378, P<0.001), logDD (r=0.70, P<0.001), vWf (r=0.214, P<0.001), and logCRP (r=0.704, P<0.001). Among them, D-dimer exhibited the characteristics most coherent with CVD. The age- and sex-adjusted odds ratio (OR) of D-dimer for the presence of CVD was 2.0, which did not change appreciably when adjustments for several pathophysiological clusters of variables were made, except for a marginal reduction in OR following adjustment for markers of inflammation. CONCLUSIONS: Among the coagulation molecules studied, plasma D-dimer levels exhibited the characteristics most coherent with associated CVD and were found to be strongly and independently associated with the prevalence of CVD in HD patients. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/16449948/Validity_of_plasma_fibrinogen_D_dimer_and_the_von_Willebrand_factor_as_markers_of_cardiovascular_morbidity_in_patients_on_chronic_hemodialysis_ L2 - https://www.medscimonit.com/download/index/idArt/445237 DB - PRIME DP - Unbound Medicine ER -