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[Age-related macular degeneration: its association with the epsilon4 allele of the apolipoprotein E gene].
Arch Soc Esp Oftalmol 2006; 81(1):9-12AS

Abstract

OBJECTIVE

The apolipoprotein E (APOE) epsilon4 allele is a well-established factor associated with age-related macular degeneration (AMD). This disorder is characterized by a typical progressive central visual impairment. Our aim was to study further the relationship of the APOE genotype associated with AMD.

MATERIALS AND METHODS

We evaluated a group of 95 patients with AMD and 65 controls. The APOE genotype for each participant in the study was determined.

RESULTS

The allele was associated with age-related macular degeneration (OR = 5.6; 95% CI = 3.4-8.8 ; p < 0.001). Female patients with at least one epsilon4 allele had a significantly earlier age at diagnosis (epsilon4+ = 72.2 S.D. 5.1; epsilon4- = 78.8 +/- 5.7; p < 0.001).

CONCLUSIONS

The APOE epsilon4 allele is not a protective factor for AMD, but is associated with an increased risk of its development.

Authors+Show Affiliations

Hospital General, Medina del Campo, Valladolid, Spain. vasensio@hmdc.sacyl.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

16450255

Citation

Asensio-Sánchez, V M., et al. "[Age-related Macular Degeneration: Its Association With the Epsilon4 Allele of the Apolipoprotein E Gene]." Archivos De La Sociedad Espanola De Oftalmologia, vol. 81, no. 1, 2006, pp. 9-12.
Asensio-Sánchez VM, Rodríguez-Martín T, Gala-Molina I, et al. [Age-related macular degeneration: its association with the epsilon4 allele of the apolipoprotein E gene]. Arch Soc Esp Oftalmol. 2006;81(1):9-12.
Asensio-Sánchez, V. M., Rodríguez-Martín, T., Gala-Molina, I., & Rodríguez-Fernández, I. (2006). [Age-related macular degeneration: its association with the epsilon4 allele of the apolipoprotein E gene]. Archivos De La Sociedad Espanola De Oftalmologia, 81(1), pp. 9-12.
Asensio-Sánchez VM, et al. [Age-related Macular Degeneration: Its Association With the Epsilon4 Allele of the Apolipoprotein E Gene]. Arch Soc Esp Oftalmol. 2006;81(1):9-12. PubMed PMID: 16450255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Age-related macular degeneration: its association with the epsilon4 allele of the apolipoprotein E gene]. AU - Asensio-Sánchez,V M, AU - Rodríguez-Martín,T, AU - Gala-Molina,I, AU - Rodríguez-Fernández,I, PY - 2006/2/2/pubmed PY - 2006/7/19/medline PY - 2006/2/2/entrez SP - 9 EP - 12 JF - Archivos de la Sociedad Espanola de Oftalmologia JO - Arch Soc Esp Oftalmol VL - 81 IS - 1 N2 - OBJECTIVE: The apolipoprotein E (APOE) epsilon4 allele is a well-established factor associated with age-related macular degeneration (AMD). This disorder is characterized by a typical progressive central visual impairment. Our aim was to study further the relationship of the APOE genotype associated with AMD. MATERIALS AND METHODS: We evaluated a group of 95 patients with AMD and 65 controls. The APOE genotype for each participant in the study was determined. RESULTS: The allele was associated with age-related macular degeneration (OR = 5.6; 95% CI = 3.4-8.8 ; p < 0.001). Female patients with at least one epsilon4 allele had a significantly earlier age at diagnosis (epsilon4+ = 72.2 S.D. 5.1; epsilon4- = 78.8 +/- 5.7; p < 0.001). CONCLUSIONS: The APOE epsilon4 allele is not a protective factor for AMD, but is associated with an increased risk of its development. SN - 0365-6691 UR - https://www.unboundmedicine.com/medline/citation/16450255/[Age_related_macular_degeneration:_its_association_with_the_epsilon4_allele_of_the_apolipoprotein_E_gene]_ L2 - http://www.diseaseinfosearch.org/result/4401 DB - PRIME DP - Unbound Medicine ER -