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Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease.
Exp Clin Endocrinol Diabetes. 2006 Jan; 114(1):1-5.EC

Abstract

INTRODUCTION

We have examined the association of bone mineral density of patients with inflammatory bowel disease with a polymorphism in the gene encoding the vitamin D receptor. The thymine/cytosine (T/C) polymorphism in the first of two start codons can be defined by a restriction fragment length polymorphism using the restriction endonuclease FokI. Vitamin D receptor alleles containing the polymorphism have been denoted by f and alleles lacking the site by F.

METHODS

We report on an association analysis of a basic population of 244 caucasian patients with Crohn's disease. We have genotyped the FokI polymorphism of the VDR in these patients and associated the genotype with the bone mineral density of the lumbar spine and the femoral neck.

RESULTS

In the cohort 42% of the patients were scored FF homozygous, 43.7% Ff heterozygous, and 14.3% ff homozygous. 14.4% of the FF patients, 18.8% of the Ff patients, and 9.7% of the ff patients had osteoporosis of the lumbar spine and 21.25% of the FF patients, 25.3% of the Ff patients, and 18.5% of the ff patients had osteoporosis of the femoral neck. In this cohort no association between the genotype and the bone mineral density in the group as a whole nor when separated according to sex or age was found.

CONCLUSIONS

In summary in our cohort no association of the FokI polymorphism and the BMD of the lumbar spine and femoral neck in patients with inflammatory bowel disease was found.

Authors+Show Affiliations

Bregenzer N
Department of Internal Medicine I, University of Regensburg, Regensburg, Germany. nicole.bregenzer@klinik.uni-regensburg.de
Schäffler A
No affiliation info available
Gelbmann CM
No affiliation info available
Steinkamp M
No affiliation info available
Reinshagen M
No affiliation info available
Schölmerich J
No affiliation info available
Andus T
No affiliation info available

MeSH

Bone DensityCervical VertebraeCodon, InitiatorCrohn DiseaseDeoxyribonucleases, Type II Site-SpecificFemaleGenotypeHumansLumbar VertebraeMalePolymorphism, Single NucleotideReceptors, Calcitriol

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16450309

Citation

Bregenzer, N, et al. "Lack of Correlation Between the Vitamin D Receptor Fokl Start Codon Polymorphism and Bone Mineral Density in Patients With Crohn's Disease." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 114, no. 1, 2006, pp. 1-5.
Bregenzer N, Schäffler A, Gelbmann CM, et al. Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease. Exp Clin Endocrinol Diabetes. 2006;114(1):1-5.
Bregenzer, N., Schäffler, A., Gelbmann, C. M., Steinkamp, M., Reinshagen, M., Schölmerich, J., & Andus, T. (2006). Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 114(1), 1-5.
Bregenzer N, et al. Lack of Correlation Between the Vitamin D Receptor Fokl Start Codon Polymorphism and Bone Mineral Density in Patients With Crohn's Disease. Exp Clin Endocrinol Diabetes. 2006;114(1):1-5. PubMed PMID: 16450309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease. AU - Bregenzer,N, AU - Schäffler,A, AU - Gelbmann,C M, AU - Steinkamp,M, AU - Reinshagen,M, AU - Schölmerich,J, AU - Andus,T, PY - 2006/2/2/pubmed PY - 2006/5/4/medline PY - 2006/2/2/entrez SP - 1 EP - 5 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 114 IS - 1 N2 - INTRODUCTION: We have examined the association of bone mineral density of patients with inflammatory bowel disease with a polymorphism in the gene encoding the vitamin D receptor. The thymine/cytosine (T/C) polymorphism in the first of two start codons can be defined by a restriction fragment length polymorphism using the restriction endonuclease FokI. Vitamin D receptor alleles containing the polymorphism have been denoted by f and alleles lacking the site by F. METHODS: We report on an association analysis of a basic population of 244 caucasian patients with Crohn's disease. We have genotyped the FokI polymorphism of the VDR in these patients and associated the genotype with the bone mineral density of the lumbar spine and the femoral neck. RESULTS: In the cohort 42% of the patients were scored FF homozygous, 43.7% Ff heterozygous, and 14.3% ff homozygous. 14.4% of the FF patients, 18.8% of the Ff patients, and 9.7% of the ff patients had osteoporosis of the lumbar spine and 21.25% of the FF patients, 25.3% of the Ff patients, and 18.5% of the ff patients had osteoporosis of the femoral neck. In this cohort no association between the genotype and the bone mineral density in the group as a whole nor when separated according to sex or age was found. CONCLUSIONS: In summary in our cohort no association of the FokI polymorphism and the BMD of the lumbar spine and femoral neck in patients with inflammatory bowel disease was found. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/16450309/Lack_of_correlation_between_the_vitamin_D_receptor_Fokl_start_codon_polymorphism_and_bone_mineral_density_in_patients_with_Crohn's_disease_ DB - PRIME DP - Unbound Medicine ER -