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The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma.
Allergy Asthma Proc. 2005 Sep-Oct; 26(5):366-72.AA

Abstract

Airway hypersensitivity is routinely evaluated by measuring the concentration (PC20) of inhaled methacholine or histamine that causes a 20% fall in forced expiratory volume in 1 second (FEV1). It has been suggested that a percentage fall in forced vital capacity (FVC) measured at the PC20 dose of inhaled agonist (deltaFVC) is a potentially useful clinical measure in patients who have asthma because it provides indirect information about gas trapping and therefore the maximal airway response. The relationships between serum eosinophil cationic protein (ECP) levels and the maximal airway response or deltaFVC are largely unknown. The aims of this study were to determine whether deltaFVC is correlated with the degree of maximal airway response and to examine the relationships between serum ECP and deltaFVC or maximal airway response in patients who have mild asthma. Fifty-eight patients with mild asthma underwent high-dose methacholine challenge testing. The PC20, maximal airway response, and deltaFVC were measured on the methacholine dose-response curves. Serum ECP levels also were determined. Subjects without a maximal response plateau (n = 33) had a significantly higher level of deltaFVC (17.9 +/- 4.1%) than subjects with a plateau (n = 25; 14.9 +/- 4.8%). A significant correlation was found between deltaFVC and the level of maximal response plateau (r = 0.446; p = 0.026). Not only methacholine PC20 but also maximal airway response or deltaFVC had no relationships with serum ECP levels. Our results suggest that deltaFVC can be used as a surrogate marker of maximal airway response in patients who have mild asthma and that neither maximal airway response nor deltaFVC reflects blood eosinophil activation any more than methacholine PC20.

Authors+Show Affiliations

Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16450571

Citation

Yu, Jinho, et al. "The Relationship Between Delta-forced Vital Capacity (percent Fall in Forced Vital Capacity at the PC20 Dose of Methacholine) and the Maximal Airway Response in Patients Who Have Mild Asthma." Allergy and Asthma Proceedings, vol. 26, no. 5, 2005, pp. 366-72.
Yu J, Yoo Y, Kim DK, et al. The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma. Allergy Asthma Proc. 2005;26(5):366-72.
Yu, J., Yoo, Y., Kim, D. K., & Koh, Y. Y. (2005). The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma. Allergy and Asthma Proceedings, 26(5), 366-72.
Yu J, et al. The Relationship Between Delta-forced Vital Capacity (percent Fall in Forced Vital Capacity at the PC20 Dose of Methacholine) and the Maximal Airway Response in Patients Who Have Mild Asthma. Allergy Asthma Proc. 2005 Sep-Oct;26(5):366-72. PubMed PMID: 16450571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma. AU - Yu,Jinho, AU - Yoo,Young, AU - Kim,Do Kyun, AU - Koh,Young Yull, PY - 2006/2/3/pubmed PY - 2006/4/12/medline PY - 2006/2/3/entrez SP - 366 EP - 72 JF - Allergy and asthma proceedings JO - Allergy Asthma Proc VL - 26 IS - 5 N2 - Airway hypersensitivity is routinely evaluated by measuring the concentration (PC20) of inhaled methacholine or histamine that causes a 20% fall in forced expiratory volume in 1 second (FEV1). It has been suggested that a percentage fall in forced vital capacity (FVC) measured at the PC20 dose of inhaled agonist (deltaFVC) is a potentially useful clinical measure in patients who have asthma because it provides indirect information about gas trapping and therefore the maximal airway response. The relationships between serum eosinophil cationic protein (ECP) levels and the maximal airway response or deltaFVC are largely unknown. The aims of this study were to determine whether deltaFVC is correlated with the degree of maximal airway response and to examine the relationships between serum ECP and deltaFVC or maximal airway response in patients who have mild asthma. Fifty-eight patients with mild asthma underwent high-dose methacholine challenge testing. The PC20, maximal airway response, and deltaFVC were measured on the methacholine dose-response curves. Serum ECP levels also were determined. Subjects without a maximal response plateau (n = 33) had a significantly higher level of deltaFVC (17.9 +/- 4.1%) than subjects with a plateau (n = 25; 14.9 +/- 4.8%). A significant correlation was found between deltaFVC and the level of maximal response plateau (r = 0.446; p = 0.026). Not only methacholine PC20 but also maximal airway response or deltaFVC had no relationships with serum ECP levels. Our results suggest that deltaFVC can be used as a surrogate marker of maximal airway response in patients who have mild asthma and that neither maximal airway response nor deltaFVC reflects blood eosinophil activation any more than methacholine PC20. SN - 1088-5412 UR - https://www.unboundmedicine.com/medline/citation/16450571/The_relationship_between_delta_forced_vital_capacity__percent_fall_in_forced_vital_capacity_at_the_PC20_dose_of_methacholine__and_the_maximal_airway_response_in_patients_who_have_mild_asthma_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -