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Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study.
BMJ. 2006 Feb 25; 332(7539):455-9.BMJ

Abstract

OBJECTIVE

To assess the potential of anticholinergic drugs as a cause of non-degenerative mild cognitive impairment in elderly people.

DESIGN

Longitudinal cohort study.

SETTING

63 randomly selected general practices in the Montpellier region of southern France.

PARTICIPANTS

372 people aged > 60 years without dementia at recruitment.

MAIN OUTCOME MEASURES

Anticholinergic burden from drug use, cognitive examination, and neurological assessment.

RESULTS

9.2% of subjects continuously used anticholinergic drugs during the year before cognitive assessment. Compared with non-users, they had poorer performance on reaction time, attention, delayed non-verbal memory, narrative recall, visuospatial construction, and language tasks but not on tasks of reasoning, immediate and delayed recall of wordlists, and implicit memory. Eighty per cent of the continuous users were classified as having mild cognitive impairment compared with 35% of non-users, and anticholinergic drug use was a strong predictor of mild cognitive impairment (odds ratio 5.12, P = 0.001). No difference was found between users and non-users in risk of developing dementia at follow-up after eight years.

CONCLUSIONS

Elderly people taking anticholinergic drugs had significant deficits in cognitive functioning and were highly likely to be classified as mildly cognitively impaired, although not at increased risk for dementia. Doctors should assess current use of anticholinergic drugs in elderly people with mild cognitive impairment before considering administration of acetylcholinesterase inhibitors.

Authors+Show Affiliations

Inserm, E361, Pathologies of the Nervous System, 34093 Montpellier, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16452102

Citation

Ancelin, Marie L., et al. "Non-degenerative Mild Cognitive Impairment in Elderly People and Use of Anticholinergic Drugs: Longitudinal Cohort Study." BMJ (Clinical Research Ed.), vol. 332, no. 7539, 2006, pp. 455-9.
Ancelin ML, Artero S, Portet F, et al. Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study. BMJ. 2006;332(7539):455-9.
Ancelin, M. L., Artero, S., Portet, F., Dupuy, A. M., Touchon, J., & Ritchie, K. (2006). Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study. BMJ (Clinical Research Ed.), 332(7539), 455-9.
Ancelin ML, et al. Non-degenerative Mild Cognitive Impairment in Elderly People and Use of Anticholinergic Drugs: Longitudinal Cohort Study. BMJ. 2006 Feb 25;332(7539):455-9. PubMed PMID: 16452102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study. AU - Ancelin,Marie L, AU - Artero,Sylvaine, AU - Portet,Florence, AU - Dupuy,Anne-Marie, AU - Touchon,Jacques, AU - Ritchie,Karen, Y1 - 2006/02/01/ PY - 2006/2/3/pubmed PY - 2006/3/3/medline PY - 2006/2/3/entrez SP - 455 EP - 9 JF - BMJ (Clinical research ed.) JO - BMJ VL - 332 IS - 7539 N2 - OBJECTIVE: To assess the potential of anticholinergic drugs as a cause of non-degenerative mild cognitive impairment in elderly people. DESIGN: Longitudinal cohort study. SETTING: 63 randomly selected general practices in the Montpellier region of southern France. PARTICIPANTS: 372 people aged > 60 years without dementia at recruitment. MAIN OUTCOME MEASURES: Anticholinergic burden from drug use, cognitive examination, and neurological assessment. RESULTS: 9.2% of subjects continuously used anticholinergic drugs during the year before cognitive assessment. Compared with non-users, they had poorer performance on reaction time, attention, delayed non-verbal memory, narrative recall, visuospatial construction, and language tasks but not on tasks of reasoning, immediate and delayed recall of wordlists, and implicit memory. Eighty per cent of the continuous users were classified as having mild cognitive impairment compared with 35% of non-users, and anticholinergic drug use was a strong predictor of mild cognitive impairment (odds ratio 5.12, P = 0.001). No difference was found between users and non-users in risk of developing dementia at follow-up after eight years. CONCLUSIONS: Elderly people taking anticholinergic drugs had significant deficits in cognitive functioning and were highly likely to be classified as mildly cognitively impaired, although not at increased risk for dementia. Doctors should assess current use of anticholinergic drugs in elderly people with mild cognitive impairment before considering administration of acetylcholinesterase inhibitors. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/16452102/Non_degenerative_mild_cognitive_impairment_in_elderly_people_and_use_of_anticholinergic_drugs:_longitudinal_cohort_study_ L2 - https://www.bmj.com/lookup/pmidlookup?view=long&pmid=16452102 DB - PRIME DP - Unbound Medicine ER -