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Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients.
J Nutr Health Aging. 2006 Jan-Feb; 10(1):3-6.JN

Abstract

OBJECTIVES

The aim of this trial was to demonstrate the efficacy of one month of oral cobalamin (vitamin B12) therapy in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM).

PATIENTS AND METHOD

Twenty elderly patients (mean age: 78+/-17 years) with established cobalamin deficiency related to FCM were included in an open-label, non-randomized, non-placebo trial. They were treated with a maximum of 1,000 microgram per day of oral crystalline cyanocobalamin for at least 1 month. Serum cobalamin levels (primary endpoint), blood count abnormalities and reticulocytes count (secondary endpoints) were determined at baseline and during the first month of treatment.

RESULTS

85% of the patients normalized their serum cobalamin levels with a mean increase of+167 pg/ml (p<0.001 compared with baseline). 100% of the patients corrected their initial macrocytosis and 25% their anemia; 100% of the patients had medullar regeneration with a mean increase of reticulocytes count of 32+/-11.3 x 106/l (p=0.03 compared with baseline).

CONCLUSIONS

Our findings support the view that one month of oral crystalline cyanocobalamin is effective to correct serum vitamin B12 levels and to obtain hematological responses in elderly patients with cobalamin deficiency related to FCM.

Authors+Show Affiliations

Andrès E
Department of Internal Medicine, Hopitaux Universitaires de Strasbourg, 67 091 Strasbourg cedex, France. emmanuel.andres@chru-strasbourg.fr
Kaltenbach G
No affiliation info available
Noblet-Dick M
No affiliation info available
Noel E
No affiliation info available
Vinzio S
No affiliation info available
Perrin AE
No affiliation info available
Berthel M
No affiliation info available
Blicklé JF
No affiliation info available

MeSH

Administration, OralAgedAgingBlood Cell CountFemaleHemoglobinsHumansIntestinal AbsorptionMalabsorption SyndromesMaleTreatment OutcomeVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16453051

Citation

Andrès, E, et al. "Hematological Response to Short-term Oral Cyanocobalamin Therapy for the Treatment of Cobalamin Deficiencies in Elderly Patients." The Journal of Nutrition, Health & Aging, vol. 10, no. 1, 2006, pp. 3-6.
Andrès E, Kaltenbach G, Noblet-Dick M, et al. Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients. J Nutr Health Aging. 2006;10(1):3-6.
Andrès, E., Kaltenbach, G., Noblet-Dick, M., Noel, E., Vinzio, S., Perrin, A. E., Berthel, M., & Blicklé, J. F. (2006). Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients. The Journal of Nutrition, Health & Aging, 10(1), 3-6.
Andrès E, et al. Hematological Response to Short-term Oral Cyanocobalamin Therapy for the Treatment of Cobalamin Deficiencies in Elderly Patients. J Nutr Health Aging. 2006 Jan-Feb;10(1):3-6. PubMed PMID: 16453051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients. AU - Andrès,E, AU - Kaltenbach,G, AU - Noblet-Dick,M, AU - Noel,E, AU - Vinzio,S, AU - Perrin,A E, AU - Berthel,M, AU - Blicklé,J F, PY - 2006/2/3/pubmed PY - 2006/4/25/medline PY - 2006/2/3/entrez SP - 3 EP - 6 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 10 IS - 1 N2 - OBJECTIVES: The aim of this trial was to demonstrate the efficacy of one month of oral cobalamin (vitamin B12) therapy in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM). PATIENTS AND METHOD: Twenty elderly patients (mean age: 78+/-17 years) with established cobalamin deficiency related to FCM were included in an open-label, non-randomized, non-placebo trial. They were treated with a maximum of 1,000 microgram per day of oral crystalline cyanocobalamin for at least 1 month. Serum cobalamin levels (primary endpoint), blood count abnormalities and reticulocytes count (secondary endpoints) were determined at baseline and during the first month of treatment. RESULTS: 85% of the patients normalized their serum cobalamin levels with a mean increase of+167 pg/ml (p<0.001 compared with baseline). 100% of the patients corrected their initial macrocytosis and 25% their anemia; 100% of the patients had medullar regeneration with a mean increase of reticulocytes count of 32+/-11.3 x 106/l (p=0.03 compared with baseline). CONCLUSIONS: Our findings support the view that one month of oral crystalline cyanocobalamin is effective to correct serum vitamin B12 levels and to obtain hematological responses in elderly patients with cobalamin deficiency related to FCM. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/16453051/Hematological_response_to_short_term_oral_cyanocobalamin_therapy_for_the_treatment_of_cobalamin_deficiencies_in_elderly_patients_ DB - PRIME DP - Unbound Medicine ER -