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Renin-angiotensin-aldosterone system, HPA-axis and sleep-EEG changes in unmedicated patients with depression after total sleep deprivation.
Pharmacopsychiatry. 2006 Jan; 39(1):23-9.P

Abstract

BACKGROUND

Changes in the activity of the renin-angiontensin-aldosterone system (RAAS) in depression have recently been reported. Renin and aldosterone secretion are coupled to sleep in healthy subjects. As total sleep deprivation (TSD) leads to a rapid mood improvement in patients with depression, it is of interest to investigate its effect on the response of the RAAS in the recovery night in this population as a possible probe for the neurobiological effects of TSD and potentially other rapid acting antidepressive interventions. Additionally we explored the HPA-system and the sleep-EEG-changes.

METHODS

We compared the sleep related activity of the RAAS before and after TSD in seven depressed patients. After an accommodation night, a polysomnographic examination was performed between 23.00 h and 7.00 h. This was followed by 40 h of TSD and a second polysomnography. During the examination blood samples were taken in the night every 20 min for analysis of renin, aldosterone, ACTH and cortisol.

RESULTS

During recovery-sleep renin was significantly increased (p < 0.05). Aldosterone showed no change. ACTH and cortisol were decreased by trend in the first half of the night. REM-density and intermittent wakefulness was significantly decreased (p < 0.05), whereas slow wave sleep increased by trend in the first half of the night.

CONCLUSION

TSD in patients with depression leads to an increase in renin secretion and a concomitant trend for a decrease in HPA axis activity in the recovery night. These changes could be a "fingerprint" of a rapidly antidepressive treatment.

Authors+Show Affiliations

Max-Planck-Institute of Psychiatry, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16453251

Citation

Murck, H, et al. "Renin-angiotensin-aldosterone System, HPA-axis and sleep-EEG Changes in Unmedicated Patients With Depression After Total Sleep Deprivation." Pharmacopsychiatry, vol. 39, no. 1, 2006, pp. 23-9.
Murck H, Uhr M, Ziegenbein M, et al. Renin-angiotensin-aldosterone system, HPA-axis and sleep-EEG changes in unmedicated patients with depression after total sleep deprivation. Pharmacopsychiatry. 2006;39(1):23-9.
Murck, H., Uhr, M., Ziegenbein, M., Künzel, H., Held, K., Antonijevic, I. A., Schüssler, P., & Steiger, A. (2006). Renin-angiotensin-aldosterone system, HPA-axis and sleep-EEG changes in unmedicated patients with depression after total sleep deprivation. Pharmacopsychiatry, 39(1), 23-9.
Murck H, et al. Renin-angiotensin-aldosterone System, HPA-axis and sleep-EEG Changes in Unmedicated Patients With Depression After Total Sleep Deprivation. Pharmacopsychiatry. 2006;39(1):23-9. PubMed PMID: 16453251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renin-angiotensin-aldosterone system, HPA-axis and sleep-EEG changes in unmedicated patients with depression after total sleep deprivation. AU - Murck,H, AU - Uhr,M, AU - Ziegenbein,M, AU - Künzel,H, AU - Held,K, AU - Antonijevic,I A, AU - Schüssler,P, AU - Steiger,A, PY - 2006/2/3/pubmed PY - 2006/3/30/medline PY - 2006/2/3/entrez SP - 23 EP - 9 JF - Pharmacopsychiatry JO - Pharmacopsychiatry VL - 39 IS - 1 N2 - BACKGROUND: Changes in the activity of the renin-angiontensin-aldosterone system (RAAS) in depression have recently been reported. Renin and aldosterone secretion are coupled to sleep in healthy subjects. As total sleep deprivation (TSD) leads to a rapid mood improvement in patients with depression, it is of interest to investigate its effect on the response of the RAAS in the recovery night in this population as a possible probe for the neurobiological effects of TSD and potentially other rapid acting antidepressive interventions. Additionally we explored the HPA-system and the sleep-EEG-changes. METHODS: We compared the sleep related activity of the RAAS before and after TSD in seven depressed patients. After an accommodation night, a polysomnographic examination was performed between 23.00 h and 7.00 h. This was followed by 40 h of TSD and a second polysomnography. During the examination blood samples were taken in the night every 20 min for analysis of renin, aldosterone, ACTH and cortisol. RESULTS: During recovery-sleep renin was significantly increased (p < 0.05). Aldosterone showed no change. ACTH and cortisol were decreased by trend in the first half of the night. REM-density and intermittent wakefulness was significantly decreased (p < 0.05), whereas slow wave sleep increased by trend in the first half of the night. CONCLUSION: TSD in patients with depression leads to an increase in renin secretion and a concomitant trend for a decrease in HPA axis activity in the recovery night. These changes could be a "fingerprint" of a rapidly antidepressive treatment. SN - 0176-3679 UR - https://www.unboundmedicine.com/medline/citation/16453251/Renin_angiotensin_aldosterone_system_HPA_axis_and_sleep_EEG_changes_in_unmedicated_patients_with_depression_after_total_sleep_deprivation_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-931476 DB - PRIME DP - Unbound Medicine ER -