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Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD).
Hum Mutat 2006; 27(4):337-42HM

Abstract

Progression of age-related macular degeneration (AMD), the leading cause of blindness in the elderly, was followed in a cohort of 238 individuals from a single center. Individuals with an epsilon (epsilon)2 genotype (c.526C>T of reference sequence NM_000041.2) of the apolipoprotein (APOE) gene were found to be strongly associated with disease with a significant 4.8-fold increased relative risk compared to individuals with an epsilon4 genotype (c.388T>C of reference sequence NM_000041.2) (odds ratio [OR], 4.8; 95% confidence interval [CI], 1.19-19.09) and a nearly significant three-fold increased relative risk compared to individuals with an epsilon3 genotype (reference sequence NM_000041.2) (OR, 2.8; 95% CI, 0.96-19.09). This finding was present only in females who progressed with AMD, which suggests that there may be a gender-specific role in progression of AMD in individuals with an epsilon2 allele. A gender-related factor is therefore implicated either directly or indirectly in the AMD disease process.

Authors+Show Affiliations

Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia. pnb@unimelb.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16453339

Citation

Baird, Paul N., et al. "Apolipoprotein (APOE) Gene Is Associated With Progression of Age-related Macular Degeneration (AMD)." Human Mutation, vol. 27, no. 4, 2006, pp. 337-42.
Baird PN, Richardson AJ, Robman LD, et al. Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). Hum Mutat. 2006;27(4):337-42.
Baird, P. N., Richardson, A. J., Robman, L. D., Dimitrov, P. N., Tikellis, G., McCarty, C. A., & Guymer, R. H. (2006). Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). Human Mutation, 27(4), pp. 337-42.
Baird PN, et al. Apolipoprotein (APOE) Gene Is Associated With Progression of Age-related Macular Degeneration (AMD). Hum Mutat. 2006;27(4):337-42. PubMed PMID: 16453339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). AU - Baird,Paul N, AU - Richardson,Andrea J, AU - Robman,Luba D, AU - Dimitrov,Peter N, AU - Tikellis,Gabriella, AU - McCarty,Catherine A, AU - Guymer,Robyn H, PY - 2006/2/3/pubmed PY - 2006/12/27/medline PY - 2006/2/3/entrez SP - 337 EP - 42 JF - Human mutation JO - Hum. Mutat. VL - 27 IS - 4 N2 - Progression of age-related macular degeneration (AMD), the leading cause of blindness in the elderly, was followed in a cohort of 238 individuals from a single center. Individuals with an epsilon (epsilon)2 genotype (c.526C>T of reference sequence NM_000041.2) of the apolipoprotein (APOE) gene were found to be strongly associated with disease with a significant 4.8-fold increased relative risk compared to individuals with an epsilon4 genotype (c.388T>C of reference sequence NM_000041.2) (odds ratio [OR], 4.8; 95% confidence interval [CI], 1.19-19.09) and a nearly significant three-fold increased relative risk compared to individuals with an epsilon3 genotype (reference sequence NM_000041.2) (OR, 2.8; 95% CI, 0.96-19.09). This finding was present only in females who progressed with AMD, which suggests that there may be a gender-specific role in progression of AMD in individuals with an epsilon2 allele. A gender-related factor is therefore implicated either directly or indirectly in the AMD disease process. SN - 1098-1004 UR - https://www.unboundmedicine.com/medline/citation/16453339/Apolipoprotein__APOE__gene_is_associated_with_progression_of_age_related_macular_degeneration__AMD__ L2 - https://doi.org/10.1002/humu.20288 DB - PRIME DP - Unbound Medicine ER -