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Therapeutic efficacy of chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Papua New Guinea.
P N G Med J. 2003 Sep-Dec; 46(3-4):125-34.PN

Abstract

Resistance of Plasmodium falciparum to chloroquine is widespread in Papua New Guinea. At a meeting in Port Moresby in October 1997, it was decided to explore a possible change of the current first-line treatment of uncomplicated malaria with chloroquine alone (amodiaquine for children under five years) to chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine (S-P). To assess the therapeutic efficacy of the new drug combination in Papua New Guinea, a study was carried out in 1998-1999 at five hospital outpatient departments. From the 513 patients enrolled for the study, 95 defaulted from follow-up. Of the remaining 418, 399 (95.5%) had an adequate clinical response (ACR). Out of the 19 patients who did not have an ACR, 3 (0.7% of the total) developed severe signs in the first 24 hours and were treated in hospital; they were regarded as early treatment failures. The remaining 16 did not complete the study on the basis of various exclusion criteria but were not excluded from the analysis. From these results it was concluded that the combination was effective and a decision was taken in May 2000 to introduce the two-drug combination regimens as the standard first-line treatment of uncomplicated malaria, including falciparum malaria, in Papua New Guinea.

Authors+Show Affiliations

Malaria Surveillance and Control Unit, Department of Health, Goroka, Papua New Guinea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16454394

Citation

Jayatilaka, K D P., et al. "Therapeutic Efficacy of Chloroquine or Amodiaquine in Combination With Sulfadoxine-pyrimethamine for Uncomplicated Falciparum Malaria in Papua New Guinea." Papua and New Guinea Medical Journal, vol. 46, no. 3-4, 2003, pp. 125-34.
Jayatilaka KD, Taviri J, Kemiki A, et al. Therapeutic efficacy of chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Papua New Guinea. P N G Med J. 2003;46(3-4):125-34.
Jayatilaka, K. D., Taviri, J., Kemiki, A., Hwaihwanje, I., & Bulungol, P. (2003). Therapeutic efficacy of chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Papua New Guinea. Papua and New Guinea Medical Journal, 46(3-4), 125-34.
Jayatilaka KD, et al. Therapeutic Efficacy of Chloroquine or Amodiaquine in Combination With Sulfadoxine-pyrimethamine for Uncomplicated Falciparum Malaria in Papua New Guinea. P N G Med J. 2003 Sep-Dec;46(3-4):125-34. PubMed PMID: 16454394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic efficacy of chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Papua New Guinea. AU - Jayatilaka,K D P, AU - Taviri,Jackson, AU - Kemiki,A, AU - Hwaihwanje,I, AU - Bulungol,Peter, PY - 2006/2/4/pubmed PY - 2006/2/17/medline PY - 2006/2/4/entrez SP - 125 EP - 34 JF - Papua and New Guinea medical journal JO - P N G Med J VL - 46 IS - 3-4 N2 - Resistance of Plasmodium falciparum to chloroquine is widespread in Papua New Guinea. At a meeting in Port Moresby in October 1997, it was decided to explore a possible change of the current first-line treatment of uncomplicated malaria with chloroquine alone (amodiaquine for children under five years) to chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine (S-P). To assess the therapeutic efficacy of the new drug combination in Papua New Guinea, a study was carried out in 1998-1999 at five hospital outpatient departments. From the 513 patients enrolled for the study, 95 defaulted from follow-up. Of the remaining 418, 399 (95.5%) had an adequate clinical response (ACR). Out of the 19 patients who did not have an ACR, 3 (0.7% of the total) developed severe signs in the first 24 hours and were treated in hospital; they were regarded as early treatment failures. The remaining 16 did not complete the study on the basis of various exclusion criteria but were not excluded from the analysis. From these results it was concluded that the combination was effective and a decision was taken in May 2000 to introduce the two-drug combination regimens as the standard first-line treatment of uncomplicated malaria, including falciparum malaria, in Papua New Guinea. SN - 0031-1480 UR - https://www.unboundmedicine.com/medline/citation/16454394/Therapeutic_efficacy_of_chloroquine_or_amodiaquine_in_combination_with_sulfadoxine_pyrimethamine_for_uncomplicated_falciparum_malaria_in_Papua_New_Guinea_ L2 - https://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -