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[Biphosphonates in oncology].
An Med Interna. 2005 Nov; 22(11):544-7.AM

Abstract

Biophosphonates are analogues of pyrophosphate. The mechanism of action of bisphosphates is the inhibition of osteoclast activation (antiresorptive mechanism). The oral bioavailability of biophosphonates is only about 1-2%, and because of gastrointestinal side effects (mainly esophageal irritation), oral agents are less useful in oncology. Biophosphonates are used for the treatment of Paget s disease of bone, the prevention of osteoporosis, and in another clinical scenarios as the prevention of bone disease after organ transplantation. In clinical oncology biophosphonates are used for the treatment of hypercalcemia of malignancy, prevention and treatment of bone events related to bone metastases, and in the prevention of osteoporosis related to breast cancer. According to American Society of Clinical Oncology (ACO) guidelines, biophosphonates should be used in hypercalcemia of malignancy and bone events related to metastases of breast cancer and multiple myeloma.

Authors+Show Affiliations

Khosravi Shahi P
Servicio de Oncología Médica, Hospital General Universitario Gregorio Marañon, Madrid. drkhosravi@hotmail.com
Díaz Muñoz de la Espada V
No affiliation info available

MeSH

Bone NeoplasmsBreast NeoplasmsDiphosphonatesHumansHypercalcemiaMultiple MyelomaNeoplasmsOsteoporosis

Pub Type(s)

English Abstract
Journal Article
Review

Language

spa

PubMed ID

16454591

Citation

Khosravi Shahi, P, and V Díaz Muñoz de la Espada. "[Biphosphonates in Oncology]." Anales De Medicina Interna (Madrid, Spain : 1984), vol. 22, no. 11, 2005, pp. 544-7.
Khosravi Shahi P, Díaz Muñoz de la Espada V. [Biphosphonates in oncology]. An Med Interna. 2005;22(11):544-7.
Khosravi Shahi, P., & Díaz Muñoz de la Espada, V. (2005). [Biphosphonates in oncology]. Anales De Medicina Interna (Madrid, Spain : 1984), 22(11), 544-7.
Khosravi Shahi P, Díaz Muñoz de la Espada V. [Biphosphonates in Oncology]. An Med Interna. 2005;22(11):544-7. PubMed PMID: 16454591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Biphosphonates in oncology]. AU - Khosravi Shahi,P, AU - Díaz Muñoz de la Espada,V, PY - 2006/2/4/pubmed PY - 2006/3/10/medline PY - 2006/2/4/entrez SP - 544 EP - 7 JF - Anales de medicina interna (Madrid, Spain : 1984) JO - An Med Interna VL - 22 IS - 11 N2 - Biophosphonates are analogues of pyrophosphate. The mechanism of action of bisphosphates is the inhibition of osteoclast activation (antiresorptive mechanism). The oral bioavailability of biophosphonates is only about 1-2%, and because of gastrointestinal side effects (mainly esophageal irritation), oral agents are less useful in oncology. Biophosphonates are used for the treatment of Paget s disease of bone, the prevention of osteoporosis, and in another clinical scenarios as the prevention of bone disease after organ transplantation. In clinical oncology biophosphonates are used for the treatment of hypercalcemia of malignancy, prevention and treatment of bone events related to bone metastases, and in the prevention of osteoporosis related to breast cancer. According to American Society of Clinical Oncology (ACO) guidelines, biophosphonates should be used in hypercalcemia of malignancy and bone events related to metastases of breast cancer and multiple myeloma. SN - 0212-7199 UR - https://www.unboundmedicine.com/medline/citation/16454591/[Biphosphonates_in_oncology]_ DB - PRIME DP - Unbound Medicine ER -