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The effects of melatonin on tinnitus and sleep.
Otolaryngol Head Neck Surg. 2006 Feb; 134(2):210-3.OH

Abstract

GOAL

To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep.

STUDY DESIGN AND SETTING

Prospective open-label study of 24 patients with tinnitus. The patients took 3 mg of melatonin per day for 4 weeks, followed by 4 weeks of observation. The Tinnitus Handicap Inventory (THI) and the Pittsburgh Sleep Quality Index (PSQI) were administered.

RESULTS

The mean THI score decreased significantly between weeks 0 and 4, and between weeks 0 and 8. The mean PSQI significantly decreased between weeks 0 and 4 (P < 0.0001), and between weeks 0 and 8 (P = 0.0003). The change in PSQI was significantly associated with the change in THI between weeks 0 and 4. The change in PSQI was not significantly associated with the change in THI between weeks 0 and 8. The change in the PSQI in the first 4 weeks was associated with the initial PSQI. There was no association between the initial THI and the change in the THI in the first 4 weeks.

CONCLUSION

Melatonin use is associated with improvement of tinnitus and sleep. There was an association between the amount of improvement in sleep and tinnitus. The impact of melatonin on sleep was greatest among patients with the worst sleep quality, but its impact on tinnitus was not associated with the severity of the tinnitus.

SIGNIFICANCE

Melatonin may be a safe treatment for patients with idiopathic tinnitus, especially those with sleep disturbance due to tinnitus.

Authors+Show Affiliations

Clinical Outcomes Research Office, Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16455366

Citation

Megwalu, Uchechukwu C., et al. "The Effects of Melatonin On Tinnitus and Sleep." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 134, no. 2, 2006, pp. 210-3.
Megwalu UC, Finnell JE, Piccirillo JF. The effects of melatonin on tinnitus and sleep. Otolaryngol Head Neck Surg. 2006;134(2):210-3.
Megwalu, U. C., Finnell, J. E., & Piccirillo, J. F. (2006). The effects of melatonin on tinnitus and sleep. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 134(2), 210-3.
Megwalu UC, Finnell JE, Piccirillo JF. The Effects of Melatonin On Tinnitus and Sleep. Otolaryngol Head Neck Surg. 2006;134(2):210-3. PubMed PMID: 16455366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of melatonin on tinnitus and sleep. AU - Megwalu,Uchechukwu C, AU - Finnell,Joshua E, AU - Piccirillo,Jay F, PY - 2005/08/09/received PY - 2006/2/4/pubmed PY - 2006/3/16/medline PY - 2006/2/4/entrez SP - 210 EP - 3 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 134 IS - 2 N2 - GOAL: To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep. STUDY DESIGN AND SETTING: Prospective open-label study of 24 patients with tinnitus. The patients took 3 mg of melatonin per day for 4 weeks, followed by 4 weeks of observation. The Tinnitus Handicap Inventory (THI) and the Pittsburgh Sleep Quality Index (PSQI) were administered. RESULTS: The mean THI score decreased significantly between weeks 0 and 4, and between weeks 0 and 8. The mean PSQI significantly decreased between weeks 0 and 4 (P < 0.0001), and between weeks 0 and 8 (P = 0.0003). The change in PSQI was significantly associated with the change in THI between weeks 0 and 4. The change in PSQI was not significantly associated with the change in THI between weeks 0 and 8. The change in the PSQI in the first 4 weeks was associated with the initial PSQI. There was no association between the initial THI and the change in the THI in the first 4 weeks. CONCLUSION: Melatonin use is associated with improvement of tinnitus and sleep. There was an association between the amount of improvement in sleep and tinnitus. The impact of melatonin on sleep was greatest among patients with the worst sleep quality, but its impact on tinnitus was not associated with the severity of the tinnitus. SIGNIFICANCE: Melatonin may be a safe treatment for patients with idiopathic tinnitus, especially those with sleep disturbance due to tinnitus. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/16455366/The_effects_of_melatonin_on_tinnitus_and_sleep_ L2 - https://journals.sagepub.com/doi/10.1016/j.otohns.2005.10.007?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -