Tags

Type your tag names separated by a space and hit enter

Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release.
Drug Dev Ind Pharm. 2006 Jan; 32(1):95-106.DD

Abstract

Directly compressed mini tablets were produced containing either hydroxypropylmethylcellulose (HPMC) or ethylcellulose (EC) as release controlling agent. The dynamics of water uptake and erosion degree of polymer were investigated. By changing the polymer concentration, the ibuprofen release was modified. In identical quantities, EC produced a greater sustaining release effect than HPMC. Different grades of viscosity of HPMC did not modify ibuprofen release. For EC formulations, the contribution of diffusion was predominant in the ibuprofen release process. For HPMC preparations, the drug release approached zero-order during a period of 8 h. For comparative purposes, tablets with 10 mm diameter were produced.

Authors+Show Affiliations

Lopes CM
Department of Pharmaceutical Technology, Faculty of Pharmacy, Oporto University, Rua Aníbal Cunha, 164-4050-047, Porto - Portugal. clopes@ff.up.pt
Sousa Lobo JM
No affiliation info available
Costa P
No affiliation info available
Pinto JF
No affiliation info available

MeSH

CelluloseDelayed-Action PreparationsHypromellose DerivativesIbuprofenMethylcelluloseSolubilityTabletsTechnology, PharmaceuticalViscosity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16455608

Citation

Lopes, Carla M., et al. "Directly Compressed Mini Matrix Tablets Containing Ibuprofen: Preparation and Evaluation of Sustained Release." Drug Development and Industrial Pharmacy, vol. 32, no. 1, 2006, pp. 95-106.
Lopes CM, Sousa Lobo JM, Costa P, et al. Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release. Drug Dev Ind Pharm. 2006;32(1):95-106.
Lopes, C. M., Sousa Lobo, J. M., Costa, P., & Pinto, J. F. (2006). Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release. Drug Development and Industrial Pharmacy, 32(1), 95-106.
Lopes CM, et al. Directly Compressed Mini Matrix Tablets Containing Ibuprofen: Preparation and Evaluation of Sustained Release. Drug Dev Ind Pharm. 2006;32(1):95-106. PubMed PMID: 16455608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release. AU - Lopes,Carla M, AU - Sousa Lobo,José Manuel, AU - Costa,Paulo, AU - Pinto,João F, PY - 2006/2/4/pubmed PY - 2006/4/28/medline PY - 2006/2/4/entrez SP - 95 EP - 106 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 32 IS - 1 N2 - Directly compressed mini tablets were produced containing either hydroxypropylmethylcellulose (HPMC) or ethylcellulose (EC) as release controlling agent. The dynamics of water uptake and erosion degree of polymer were investigated. By changing the polymer concentration, the ibuprofen release was modified. In identical quantities, EC produced a greater sustaining release effect than HPMC. Different grades of viscosity of HPMC did not modify ibuprofen release. For EC formulations, the contribution of diffusion was predominant in the ibuprofen release process. For HPMC preparations, the drug release approached zero-order during a period of 8 h. For comparative purposes, tablets with 10 mm diameter were produced. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/16455608/Directly_compressed_mini_matrix_tablets_containing_ibuprofen:_preparation_and_evaluation_of_sustained_release_ DB - PRIME DP - Unbound Medicine ER -