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Prevalence of celiac disease in Brazilian children with type 1 diabetes mellitus.
J Pediatr Gastroenterol Nutr. 2006 Feb; 42(2):155-9.JP

Abstract

OBJECTIVE

Although the relationship between celiac disease and diabetes mellitus type 1 is well recognized, there are no studies of this association in Brazil. This study aims to identify the prevalence of celiac disease in a group of children with diabetes mellitus type 1 undergoing treatment in the pediatric endocrinology division of a university hospital in Minas Gerais, Brazil.

METHODS

Immunoglobulin (Ig)A and IgG antigliadin antibodies (enzyme-linked immunoadsorbent assay) were measured in blood collected from 236 children and adolescents with diabetes mellitus type 1. Patients with antigliadin antibodies then had jejunal biopsy and determination of antiendomysial antibodies by indirect immunofluorescence.

RESULTS

Twenty-one patients had IgA or IgG antigliadin antibodies. Nineteen underwent jejunal biopsy. Six had mucosal alterations compatible with celiac disease; four had nonspecific histologic changes; nine had normal biopsies. Thirteen antigliadin antibody-positive patients were antiendomysial antibody-negative; one antiendomysial antibody-negative patient had celiac disease. The prevalence of celiac disease was 2.6% among 234 patients.

CONCLUSIONS

Measurement of antigliadin antibodies in patients with diabetes mellitus type 1 helped in the selection of patients to undergo jejunal biopsy. Antiendomysial antibodies were highly specific and moderately sensitive in predicting celiac disease. The prevalence of celiac disease was higher in diabetics than in the general population, suggesting the need for regular screening assessment of diabetic children.

Authors+Show Affiliations

Division of Paediatric Endocrinology, University Hospital, Universidade Federal de Minas Gerais, Avenida Alfredo Balena 190, s/4061, 30130-100 Belo Horizonte, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16456407

Citation

Tanure, Mariella Guarino, et al. "Prevalence of Celiac Disease in Brazilian Children With Type 1 Diabetes Mellitus." Journal of Pediatric Gastroenterology and Nutrition, vol. 42, no. 2, 2006, pp. 155-9.
Tanure MG, Silva IN, Bahia M, et al. Prevalence of celiac disease in Brazilian children with type 1 diabetes mellitus. J Pediatr Gastroenterol Nutr. 2006;42(2):155-9.
Tanure, M. G., Silva, I. N., Bahia, M., & Penna, F. J. (2006). Prevalence of celiac disease in Brazilian children with type 1 diabetes mellitus. Journal of Pediatric Gastroenterology and Nutrition, 42(2), 155-9.
Tanure MG, et al. Prevalence of Celiac Disease in Brazilian Children With Type 1 Diabetes Mellitus. J Pediatr Gastroenterol Nutr. 2006;42(2):155-9. PubMed PMID: 16456407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of celiac disease in Brazilian children with type 1 diabetes mellitus. AU - Tanure,Mariella Guarino, AU - Silva,Ivani Novato, AU - Bahia,Magda, AU - Penna,Francisco José, PY - 2006/2/4/pubmed PY - 2006/7/25/medline PY - 2006/2/4/entrez SP - 155 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 42 IS - 2 N2 - OBJECTIVE: Although the relationship between celiac disease and diabetes mellitus type 1 is well recognized, there are no studies of this association in Brazil. This study aims to identify the prevalence of celiac disease in a group of children with diabetes mellitus type 1 undergoing treatment in the pediatric endocrinology division of a university hospital in Minas Gerais, Brazil. METHODS: Immunoglobulin (Ig)A and IgG antigliadin antibodies (enzyme-linked immunoadsorbent assay) were measured in blood collected from 236 children and adolescents with diabetes mellitus type 1. Patients with antigliadin antibodies then had jejunal biopsy and determination of antiendomysial antibodies by indirect immunofluorescence. RESULTS: Twenty-one patients had IgA or IgG antigliadin antibodies. Nineteen underwent jejunal biopsy. Six had mucosal alterations compatible with celiac disease; four had nonspecific histologic changes; nine had normal biopsies. Thirteen antigliadin antibody-positive patients were antiendomysial antibody-negative; one antiendomysial antibody-negative patient had celiac disease. The prevalence of celiac disease was 2.6% among 234 patients. CONCLUSIONS: Measurement of antigliadin antibodies in patients with diabetes mellitus type 1 helped in the selection of patients to undergo jejunal biopsy. Antiendomysial antibodies were highly specific and moderately sensitive in predicting celiac disease. The prevalence of celiac disease was higher in diabetics than in the general population, suggesting the need for regular screening assessment of diabetic children. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/16456407/Prevalence_of_celiac_disease_in_Brazilian_children_with_type_1_diabetes_mellitus_ L2 - http://dx.doi.org/10.1097/01.mpg.0000189338.15763.4a DB - PRIME DP - Unbound Medicine ER -