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Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex.
Brain Res. 2006 Feb 16; 1073-1074:131-8.BR

Abstract

In the auditory cortex, the properties of NMDA receptors depend primarily on the ratio of NR2A and NR2B subunits. NR2B subunit expression is high at the beginning of critical period and lower in adulthood. Because NMDA receptors are crucial in triggering long-term potentiation (LTP) and long-term depression, developmental or experience-dependent modification of NMDAR subunit composition is likely to influence synaptic plasticity. To examine how NMDA subunit change during postnatal development affect the adult synaptic plasticity, we employed chronic ifenprodil blockade of NR2B subunits and analyzed evoked field potentials in adult C57BL/6 mice auditory cortex (AC). We found that chronic loss of NR2B activity led to a decline in LTP magnitude in the AC of adult mice. Adding NMDA to the artificial cerebrospinal fluid (ACSF) in blocked mice had the opposite effect, producing LTP magnitudes at or exceeding those found in treated or untreated animals. These results suggest that, even in adulthood when NR2B expression is downregulated, these receptor subunits play an important role in experience-dependent plasticity of mouse auditory cortex. Blockade from P60 did not result in any decrease of LTP amplitude, suggesting that chronic block in postnatal period may permanently affect cortical circuits so that they cannot produce significant LTP in adulthood.

Authors+Show Affiliations

Research Center for Brain Science, East China Normal University, Shanghai 200062, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16457785

Citation

Mao, Yuting, et al. "Early Chronic Blockade of NR2B Subunits and Transient Activation of NMDA Receptors Modulate LTP in Mouse Auditory Cortex." Brain Research, vol. 1073-1074, 2006, pp. 131-8.
Mao Y, Zang S, Zhang J, et al. Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. Brain Res. 2006;1073-1074:131-8.
Mao, Y., Zang, S., Zhang, J., & Sun, X. (2006). Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. Brain Research, 1073-1074, 131-8.
Mao Y, et al. Early Chronic Blockade of NR2B Subunits and Transient Activation of NMDA Receptors Modulate LTP in Mouse Auditory Cortex. Brain Res. 2006 Feb 16;1073-1074:131-8. PubMed PMID: 16457785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. AU - Mao,Yuting, AU - Zang,Shaoyun, AU - Zhang,Jiping, AU - Sun,Xinde, Y1 - 2006/02/02/ PY - 2005/03/30/received PY - 2005/12/11/revised PY - 2005/12/15/accepted PY - 2006/2/7/pubmed PY - 2006/7/20/medline PY - 2006/2/7/entrez SP - 131 EP - 8 JF - Brain research JO - Brain Res VL - 1073-1074 N2 - In the auditory cortex, the properties of NMDA receptors depend primarily on the ratio of NR2A and NR2B subunits. NR2B subunit expression is high at the beginning of critical period and lower in adulthood. Because NMDA receptors are crucial in triggering long-term potentiation (LTP) and long-term depression, developmental or experience-dependent modification of NMDAR subunit composition is likely to influence synaptic plasticity. To examine how NMDA subunit change during postnatal development affect the adult synaptic plasticity, we employed chronic ifenprodil blockade of NR2B subunits and analyzed evoked field potentials in adult C57BL/6 mice auditory cortex (AC). We found that chronic loss of NR2B activity led to a decline in LTP magnitude in the AC of adult mice. Adding NMDA to the artificial cerebrospinal fluid (ACSF) in blocked mice had the opposite effect, producing LTP magnitudes at or exceeding those found in treated or untreated animals. These results suggest that, even in adulthood when NR2B expression is downregulated, these receptor subunits play an important role in experience-dependent plasticity of mouse auditory cortex. Blockade from P60 did not result in any decrease of LTP amplitude, suggesting that chronic block in postnatal period may permanently affect cortical circuits so that they cannot produce significant LTP in adulthood. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/16457785/Early_chronic_blockade_of_NR2B_subunits_and_transient_activation_of_NMDA_receptors_modulate_LTP_in_mouse_auditory_cortex_ DB - PRIME DP - Unbound Medicine ER -