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[Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+].
Rinsho Ketsueki. 1991 Mar; 32(3):231-8.RK

Abstract

A 63 year-old woman was referred to our hospital because of fever and increased number of blasts in the bone marrow. On physical examination she had slight hepatomegaly but no splenomegaly. Laboratory tests disclosed a hemoglobin level of 8.5 g/dl; a WBC count of 13,200/microliter with 26% blasts; a platelet count of 51,000/microliter. A bone marrow aspirate was normocellular with 74% blasts and 37% blasts were stained positive for myeloperoxidase. Cell surface markers for HLA-DR, CD10, CD19, CD13, CD33 were positive. Karyotype analysis revealed 46, XX, t (9q+; 22q-) and 45XX, -7, t (9q+; 22q-). Southern analysis showed rearrangement of immunoglobulin heavy chain but not T cell receptor beta gene. Rearrangements in M-BCR were not detected with 5' or 3' bcr probes. After 2 courses of chemotherapy, blasts decreased to 7% with recovery of normal elements and 11 out of 20 metaphases of the bone marrow cells were normal karyotype. These findings suggest that this case was de novo Ph1 positive acute leukemia which demonstrated both lymphoid and myeloid features.

Authors+Show Affiliations

Department of Internal Medicine, Anjyo Kosei Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

1645807

Citation

Nagata, K, et al. "[Biphenotypic Acute Leukemia With Ph1 Chromosome, M-BCR-, Myeloperoxidase+, and CALLA+]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 32, no. 3, 1991, pp. 231-8.
Nagata K, Hatanaka T, Yamamoto K, et al. [Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+]. Rinsho Ketsueki. 1991;32(3):231-8.
Nagata, K., Hatanaka, T., Yamamoto, K., Ito, T., Saito, M., Ono, Y., Kamiya, O., Ohara, K., Hoshino, A., & Yamazaki, K. (1991). [Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 32(3), 231-8.
Nagata K, et al. [Biphenotypic Acute Leukemia With Ph1 Chromosome, M-BCR-, Myeloperoxidase+, and CALLA+]. Rinsho Ketsueki. 1991;32(3):231-8. PubMed PMID: 1645807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+]. A1 - Nagata,K, AU - Hatanaka,T, AU - Yamamoto,K, AU - Ito,T, AU - Saito,M, AU - Ono,Y, AU - Kamiya,O, AU - Ohara,K, AU - Hoshino,A, AU - Yamazaki,K, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 231 EP - 8 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 32 IS - 3 N2 - A 63 year-old woman was referred to our hospital because of fever and increased number of blasts in the bone marrow. On physical examination she had slight hepatomegaly but no splenomegaly. Laboratory tests disclosed a hemoglobin level of 8.5 g/dl; a WBC count of 13,200/microliter with 26% blasts; a platelet count of 51,000/microliter. A bone marrow aspirate was normocellular with 74% blasts and 37% blasts were stained positive for myeloperoxidase. Cell surface markers for HLA-DR, CD10, CD19, CD13, CD33 were positive. Karyotype analysis revealed 46, XX, t (9q+; 22q-) and 45XX, -7, t (9q+; 22q-). Southern analysis showed rearrangement of immunoglobulin heavy chain but not T cell receptor beta gene. Rearrangements in M-BCR were not detected with 5' or 3' bcr probes. After 2 courses of chemotherapy, blasts decreased to 7% with recovery of normal elements and 11 out of 20 metaphases of the bone marrow cells were normal karyotype. These findings suggest that this case was de novo Ph1 positive acute leukemia which demonstrated both lymphoid and myeloid features. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/1645807/[Biphenotypic_acute_leukemia_with_Ph1_chromosome_M_BCR__myeloperoxidase+_and_CALLA+]_ L2 - http://www.diseaseinfosearch.org/result/179 DB - PRIME DP - Unbound Medicine ER -