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Comparison of the effects of latanoprost, travoprost, and bimatoprost on circadian intraocular pressure in patients with glaucoma or ocular hypertension.

Abstract

PURPOSE

To compare 24-hour reduction in intraocular pressure (IOP) by latanoprost 0.005%, travoprost 0.004%, and bimatoprost 0.03% in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH).

DESIGN

Randomized, double-masked, crossover study.

PARTICIPANTS

Twenty-four patients with POAG and 20 with OH.

METHODS

Patients were treated with latanoprost, travoprost, and bimatoprost for 1 month. The treatment sequence was randomized, and washout lasted 30 days for each trial drug. Four 24-hour tonometric curves were recorded for each patient: 1 at baseline and 1 after each treatment period.

MAIN OUTCOME MEASURES

Intraocular pressure was measured at 3, 6, and 9 am; noon; 3, 6, and 9 pm; and midnight by 2 treatment-masked well-trained evaluators using a handheld electronic tonometer with the patient in supine and sitting positions and a Goldmann applanation tonometer with the patient sitting at the slit lamp. Supine systemic blood pressure was recorded at the same times. A randomized-blocks analysis of variance was used to analyze data.

RESULTS

All 3 drugs were highly effective in reducing IOP when compared to baseline. Mean IOP reductions were similar after the 3 prostaglandin analogs, and none of the differences among treatments reached statistical significance. The drugs' effect was significantly greater during the daytime (9 am-9 pm) than during the nighttime (midnight-6 am) with all prostaglandin analogs. In 7 of 44 patients (16%), nocturnal IOP was significantly higher than diurnal IOP, both at baseline and under the 3 prostaglandin analogs.

CONCLUSIONS

From a clinical point of view, the overall results seem to indicate that the 3 prostaglandin analogs are powerful agents in controlling round-the-clock IOP in POAG and OH patients.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Eye Clinic, Department of Medicine, Surgery and Odontoiatry, University of Milan San Paolo Hospital, Milan, Italy.

    , ,

    Source

    Ophthalmology 113:2 2006 Feb pg 239-46

    MeSH

    Aged
    Amides
    Antihypertensive Agents
    Bimatoprost
    Blood Pressure
    Circadian Rhythm
    Cloprostenol
    Cross-Over Studies
    Double-Blind Method
    Female
    Glaucoma, Open-Angle
    Humans
    Intraocular Pressure
    Latanoprost
    Lipids
    Male
    Ocular Hypertension
    Ophthalmic Solutions
    Prostaglandins F, Synthetic
    Tonometry, Ocular
    Travoprost

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    16458092

    Citation

    Orzalesi, Nicola, et al. "Comparison of the Effects of Latanoprost, Travoprost, and Bimatoprost On Circadian Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension." Ophthalmology, vol. 113, no. 2, 2006, pp. 239-46.
    Orzalesi N, Rossetti L, Bottoli A, et al. Comparison of the effects of latanoprost, travoprost, and bimatoprost on circadian intraocular pressure in patients with glaucoma or ocular hypertension. Ophthalmology. 2006;113(2):239-46.
    Orzalesi, N., Rossetti, L., Bottoli, A., & Fogagnolo, P. (2006). Comparison of the effects of latanoprost, travoprost, and bimatoprost on circadian intraocular pressure in patients with glaucoma or ocular hypertension. Ophthalmology, 113(2), pp. 239-46.
    Orzalesi N, et al. Comparison of the Effects of Latanoprost, Travoprost, and Bimatoprost On Circadian Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension. Ophthalmology. 2006;113(2):239-46. PubMed PMID: 16458092.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparison of the effects of latanoprost, travoprost, and bimatoprost on circadian intraocular pressure in patients with glaucoma or ocular hypertension. AU - Orzalesi,Nicola, AU - Rossetti,Luca, AU - Bottoli,Andrea, AU - Fogagnolo,Paolo, PY - 2005/02/22/received PY - 2005/09/05/revised PY - 2005/10/31/accepted PY - 2006/2/7/pubmed PY - 2006/2/16/medline PY - 2006/2/7/entrez SP - 239 EP - 46 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 2 N2 - PURPOSE: To compare 24-hour reduction in intraocular pressure (IOP) by latanoprost 0.005%, travoprost 0.004%, and bimatoprost 0.03% in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH). DESIGN: Randomized, double-masked, crossover study. PARTICIPANTS: Twenty-four patients with POAG and 20 with OH. METHODS: Patients were treated with latanoprost, travoprost, and bimatoprost for 1 month. The treatment sequence was randomized, and washout lasted 30 days for each trial drug. Four 24-hour tonometric curves were recorded for each patient: 1 at baseline and 1 after each treatment period. MAIN OUTCOME MEASURES: Intraocular pressure was measured at 3, 6, and 9 am; noon; 3, 6, and 9 pm; and midnight by 2 treatment-masked well-trained evaluators using a handheld electronic tonometer with the patient in supine and sitting positions and a Goldmann applanation tonometer with the patient sitting at the slit lamp. Supine systemic blood pressure was recorded at the same times. A randomized-blocks analysis of variance was used to analyze data. RESULTS: All 3 drugs were highly effective in reducing IOP when compared to baseline. Mean IOP reductions were similar after the 3 prostaglandin analogs, and none of the differences among treatments reached statistical significance. The drugs' effect was significantly greater during the daytime (9 am-9 pm) than during the nighttime (midnight-6 am) with all prostaglandin analogs. In 7 of 44 patients (16%), nocturnal IOP was significantly higher than diurnal IOP, both at baseline and under the 3 prostaglandin analogs. CONCLUSIONS: From a clinical point of view, the overall results seem to indicate that the 3 prostaglandin analogs are powerful agents in controlling round-the-clock IOP in POAG and OH patients. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16458092/Comparison_of_the_effects_of_latanoprost_travoprost_and_bimatoprost_on_circadian_intraocular_pressure_in_patients_with_glaucoma_or_ocular_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(05)01286-8 DB - PRIME DP - Unbound Medicine ER -