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Extensive Mongolian spots: a clinical sign merits special attention.
Pediatr Neurol 2006; 34(2):143-5PN

Abstract

Although typical and limited Mongolian spots are benign skin markings at birth which fade and disappear as the child grows, extensive Mongolian spots deserve special attention as possible indications of associated inborn error of metabolism. A few cases of extensive Mongolian spots in association with inheritable storage diseases have been reported. Some hypotheses have been put forward, but further investigation is necessary to elucidate the causative factors. This report describes three infants with generalized Mongolian spots, two infants with GM1 gangliosidosis type 1, and one in association with Hurler syndrome. Findings of generalized Mongolian spots in newborns may lead to an early detection and early treatment before irreversible organ damage occurs.

Authors+Show Affiliations

Department of Pediatric Neurology, Children's Medical Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16458829

Citation

Ashrafi, Mahmood Reza, et al. "Extensive Mongolian Spots: a Clinical Sign Merits Special Attention." Pediatric Neurology, vol. 34, no. 2, 2006, pp. 143-5.
Ashrafi MR, Shabanian R, Mohammadi M, et al. Extensive Mongolian spots: a clinical sign merits special attention. Pediatr Neurol. 2006;34(2):143-5.
Ashrafi, M. R., Shabanian, R., Mohammadi, M., & Kavusi, S. (2006). Extensive Mongolian spots: a clinical sign merits special attention. Pediatric Neurology, 34(2), pp. 143-5.
Ashrafi MR, et al. Extensive Mongolian Spots: a Clinical Sign Merits Special Attention. Pediatr Neurol. 2006;34(2):143-5. PubMed PMID: 16458829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extensive Mongolian spots: a clinical sign merits special attention. AU - Ashrafi,Mahmood Reza, AU - Shabanian,Reza, AU - Mohammadi,Mahmood, AU - Kavusi,Susan, PY - 2005/04/19/received PY - 2005/05/26/revised PY - 2004/07/11/accepted PY - 2006/2/7/pubmed PY - 2006/5/19/medline PY - 2006/2/7/entrez SP - 143 EP - 5 JF - Pediatric neurology JO - Pediatr. Neurol. VL - 34 IS - 2 N2 - Although typical and limited Mongolian spots are benign skin markings at birth which fade and disappear as the child grows, extensive Mongolian spots deserve special attention as possible indications of associated inborn error of metabolism. A few cases of extensive Mongolian spots in association with inheritable storage diseases have been reported. Some hypotheses have been put forward, but further investigation is necessary to elucidate the causative factors. This report describes three infants with generalized Mongolian spots, two infants with GM1 gangliosidosis type 1, and one in association with Hurler syndrome. Findings of generalized Mongolian spots in newborns may lead to an early detection and early treatment before irreversible organ damage occurs. SN - 0887-8994 UR - https://www.unboundmedicine.com/medline/citation/16458829/Extensive_Mongolian_spots:_a_clinical_sign_merits_special_attention_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-8994(05)00413-3 DB - PRIME DP - Unbound Medicine ER -