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Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer.
Prev Med 2006; 42(3):200-5PM

Abstract

OBJECTIVE

The objective of this study was to examine the association between active cigarette smoking, household passive smoke exposure, and pancreatic cancer risk using a prospective cohort design.

METHODS

Two cohorts were established in Washington County, Maryland in 1963 (n = 45,749) and 1975 (n = 48,172). The Washington County Cancer Registry was used to ascertain the occurrence of pancreatic cancer in the 1963 cohort from 1963-1978 and in the 1975 cohort from 1975-1994. Poisson regression was used to analyze the associations between active smoking and household passive smoke exposure and pancreatic cancer risk.

RESULTS

Current active smoking was associated with a two-fold increased risk of pancreatic cancer in both cohorts. Among never-smokers in each cohort, exposure to household passive smoke was not associated with an increased risk of pancreatic cancer, although the confidence limits were wide due to a small number of cases.

CONCLUSIONS

This study further documents the approximate doubling of pancreatic cancer risk in current active smokers. Our results also indicate that household passive smoke exposure is not associated with pancreatic cancer risk, although our risk estimates lacked precision.

Authors+Show Affiliations

Department of Epidemiology, Room E6132, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16458957

Citation

Gallicchio, Lisa, et al. "Active Cigarette Smoking, Household Passive Smoke Exposure, and the Risk of Developing Pancreatic Cancer." Preventive Medicine, vol. 42, no. 3, 2006, pp. 200-5.
Gallicchio L, Kouzis A, Genkinger JM, et al. Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer. Prev Med. 2006;42(3):200-5.
Gallicchio, L., Kouzis, A., Genkinger, J. M., Burke, A. E., Hoffman, S. C., Diener-West, M., ... Alberg, A. J. (2006). Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer. Preventive Medicine, 42(3), pp. 200-5.
Gallicchio L, et al. Active Cigarette Smoking, Household Passive Smoke Exposure, and the Risk of Developing Pancreatic Cancer. Prev Med. 2006;42(3):200-5. PubMed PMID: 16458957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer. AU - Gallicchio,Lisa, AU - Kouzis,Anthony, AU - Genkinger,Jeanine M, AU - Burke,Alyce E, AU - Hoffman,Sandra C, AU - Diener-West,Marie, AU - Helzlsouer,Kathy J, AU - Comstock,George W, AU - Alberg,Anthony J, Y1 - 2006/02/03/ PY - 2005/04/03/received PY - 2005/12/08/revised PY - 2005/12/08/accepted PY - 2006/2/7/pubmed PY - 2007/1/31/medline PY - 2006/2/7/entrez SP - 200 EP - 5 JF - Preventive medicine JO - Prev Med VL - 42 IS - 3 N2 - OBJECTIVE: The objective of this study was to examine the association between active cigarette smoking, household passive smoke exposure, and pancreatic cancer risk using a prospective cohort design. METHODS: Two cohorts were established in Washington County, Maryland in 1963 (n = 45,749) and 1975 (n = 48,172). The Washington County Cancer Registry was used to ascertain the occurrence of pancreatic cancer in the 1963 cohort from 1963-1978 and in the 1975 cohort from 1975-1994. Poisson regression was used to analyze the associations between active smoking and household passive smoke exposure and pancreatic cancer risk. RESULTS: Current active smoking was associated with a two-fold increased risk of pancreatic cancer in both cohorts. Among never-smokers in each cohort, exposure to household passive smoke was not associated with an increased risk of pancreatic cancer, although the confidence limits were wide due to a small number of cases. CONCLUSIONS: This study further documents the approximate doubling of pancreatic cancer risk in current active smokers. Our results also indicate that household passive smoke exposure is not associated with pancreatic cancer risk, although our risk estimates lacked precision. SN - 0091-7435 UR - https://www.unboundmedicine.com/medline/citation/16458957/Active_cigarette_smoking_household_passive_smoke_exposure_and_the_risk_of_developing_pancreatic_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(05)00269-0 DB - PRIME DP - Unbound Medicine ER -