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What has been learnt from study of dopamine receptors in Parkinson's disease?
Pharmacol Ther. 2006 Sep; 111(3):715-28.P&T

Abstract

Since the introduction of dopamine replacement therapy using L-3,4-dihydroxyphenyalanine (L-DOPA) to treat Parkinson's disease and the recognition of the problems associated with L-DOPA use, numerous studies have investigated dopamine receptor regulation and function in Parkinson's disease. These studies have provided insight into the pathological process of the disorder and the molecular consequences of chronic dopaminergic treatment, but they have been less successful in identifying new pharmacological targets or treatment regimes that are as effective as L-DOPA at alleviating the symptoms of Parkinson's disease. This review will present a summary of the reported changes in dopamine receptor regulation and function that occur in Parkinson's disease and will discuss their contribution to the current pharmacological management of Parkinson's disease.

Authors+Show Affiliations

Neurodegenerative Diseases Research Group, School of Biomedical and Health Sciences, King's College London, SE1 1UL, United Kingdom. michael.j.hurley@kcl.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16458973

Citation

Hurley, M J., and P Jenner. "What Has Been Learnt From Study of Dopamine Receptors in Parkinson's Disease?" Pharmacology & Therapeutics, vol. 111, no. 3, 2006, pp. 715-28.
Hurley MJ, Jenner P. What has been learnt from study of dopamine receptors in Parkinson's disease? Pharmacol Ther. 2006;111(3):715-28.
Hurley, M. J., & Jenner, P. (2006). What has been learnt from study of dopamine receptors in Parkinson's disease? Pharmacology & Therapeutics, 111(3), 715-28.
Hurley MJ, Jenner P. What Has Been Learnt From Study of Dopamine Receptors in Parkinson's Disease. Pharmacol Ther. 2006;111(3):715-28. PubMed PMID: 16458973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What has been learnt from study of dopamine receptors in Parkinson's disease? AU - Hurley,M J, AU - Jenner,P, Y1 - 2006/02/03/ PY - 2005/12/23/received PY - 2005/12/23/accepted PY - 2006/2/7/pubmed PY - 2006/12/9/medline PY - 2006/2/7/entrez SP - 715 EP - 28 JF - Pharmacology & therapeutics JO - Pharmacol Ther VL - 111 IS - 3 N2 - Since the introduction of dopamine replacement therapy using L-3,4-dihydroxyphenyalanine (L-DOPA) to treat Parkinson's disease and the recognition of the problems associated with L-DOPA use, numerous studies have investigated dopamine receptor regulation and function in Parkinson's disease. These studies have provided insight into the pathological process of the disorder and the molecular consequences of chronic dopaminergic treatment, but they have been less successful in identifying new pharmacological targets or treatment regimes that are as effective as L-DOPA at alleviating the symptoms of Parkinson's disease. This review will present a summary of the reported changes in dopamine receptor regulation and function that occur in Parkinson's disease and will discuss their contribution to the current pharmacological management of Parkinson's disease. SN - 0163-7258 UR - https://www.unboundmedicine.com/medline/citation/16458973/What_has_been_learnt_from_study_of_dopamine_receptors_in_Parkinson's_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-7258(05)00283-4 DB - PRIME DP - Unbound Medicine ER -