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Lipid profile of rats fed high-fat diets based on flaxseed, peanut, trout, or chicken skin.
Nutrition. 2006 Feb; 22(2):197-205.N

Abstract

OBJECTIVE

Dietary saturated fatty acids are associated with coronary disease. Conversely, dietary monounsaturated polyunsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) seem to exert a protective effect. This study evaluated the lipid profile of rats fed high-fat (HF) diets, with fat added as different sources of PUFA (flaxseed and trout), MUFA (peanut), and saturated fatty acid (chicken skin).

METHODS

Adult male Wistar rats were placed into six dietary groups (n = 10): control (normal); high fat, with 1% cholesterol, 10% soy oil, and 5% lard; and four groups fed similar HF diets, with 10% lipid as trout, flaxseed, peanut, or chicken skin. After 28 d the animals were killed. Blood, livers, and adipose tissue samples were collected.

RESULTS

A higher level (P < 0.05) of total serum cholesterol was observed in rats fed the normal diet (93.57 +/- 14.95 mg/dL) compared with those fed the HF diet (67.57 +/- 12.54 mg/dL). Total cholesterol levels in rats fed the flaxseed diet were lower (P < 0.05) than in rats fed the other fats. No difference was observed in cholesterol levels between groups fed the peanut and chicken skin diets (P > 0.05). Animals fed the peanut diet showed decreased body weight gain than did animals in the other treatment groups. There were large lipid and cholesterol depositions in livers of rats fed the HF diet. Lipid deposition in adipose tissue followed the same dietary fatty acid profile, i.e., high levels of omega-3 PUFA in the flaxseed group, high levels of MUFA in the peanut and chicken skin groups and high levels of omega-6 PUFA in the trout group.

CONCLUSIONS

These data indicate that flaxseed is promising for dietary manipulation of hyperlipidemia.

Authors+Show Affiliations

Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16459232

Citation

Cintra, Dennys E C., et al. "Lipid Profile of Rats Fed High-fat Diets Based On Flaxseed, Peanut, Trout, or Chicken Skin." Nutrition (Burbank, Los Angeles County, Calif.), vol. 22, no. 2, 2006, pp. 197-205.
Cintra DE, Costa AV, Peluzio Mdo C, et al. Lipid profile of rats fed high-fat diets based on flaxseed, peanut, trout, or chicken skin. Nutrition. 2006;22(2):197-205.
Cintra, D. E., Costa, A. V., Peluzio, M. d. o. . C., Matta, S. L., Silva, M. T., & Costa, N. M. (2006). Lipid profile of rats fed high-fat diets based on flaxseed, peanut, trout, or chicken skin. Nutrition (Burbank, Los Angeles County, Calif.), 22(2), 197-205.
Cintra DE, et al. Lipid Profile of Rats Fed High-fat Diets Based On Flaxseed, Peanut, Trout, or Chicken Skin. Nutrition. 2006;22(2):197-205. PubMed PMID: 16459232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid profile of rats fed high-fat diets based on flaxseed, peanut, trout, or chicken skin. AU - Cintra,Dennys E C, AU - Costa,Andrég V, AU - Peluzio,Maria do Carmo G, AU - Matta,Sérgio L P, AU - Silva,Marco Túlio C, AU - Costa,Neuza M B, PY - 2005/05/04/received PY - 2005/09/01/revised PY - 2005/09/03/accepted PY - 2006/2/7/pubmed PY - 2006/8/1/medline PY - 2006/2/7/entrez SP - 197 EP - 205 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 22 IS - 2 N2 - OBJECTIVE: Dietary saturated fatty acids are associated with coronary disease. Conversely, dietary monounsaturated polyunsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) seem to exert a protective effect. This study evaluated the lipid profile of rats fed high-fat (HF) diets, with fat added as different sources of PUFA (flaxseed and trout), MUFA (peanut), and saturated fatty acid (chicken skin). METHODS: Adult male Wistar rats were placed into six dietary groups (n = 10): control (normal); high fat, with 1% cholesterol, 10% soy oil, and 5% lard; and four groups fed similar HF diets, with 10% lipid as trout, flaxseed, peanut, or chicken skin. After 28 d the animals were killed. Blood, livers, and adipose tissue samples were collected. RESULTS: A higher level (P < 0.05) of total serum cholesterol was observed in rats fed the normal diet (93.57 +/- 14.95 mg/dL) compared with those fed the HF diet (67.57 +/- 12.54 mg/dL). Total cholesterol levels in rats fed the flaxseed diet were lower (P < 0.05) than in rats fed the other fats. No difference was observed in cholesterol levels between groups fed the peanut and chicken skin diets (P > 0.05). Animals fed the peanut diet showed decreased body weight gain than did animals in the other treatment groups. There were large lipid and cholesterol depositions in livers of rats fed the HF diet. Lipid deposition in adipose tissue followed the same dietary fatty acid profile, i.e., high levels of omega-3 PUFA in the flaxseed group, high levels of MUFA in the peanut and chicken skin groups and high levels of omega-6 PUFA in the trout group. CONCLUSIONS: These data indicate that flaxseed is promising for dietary manipulation of hyperlipidemia. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16459232/Lipid_profile_of_rats_fed_high_fat_diets_based_on_flaxseed_peanut_trout_or_chicken_skin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00293-5 DB - PRIME DP - Unbound Medicine ER -