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Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania.

Abstract

There is an emerging body of data suggesting that mood disorders are associated with decreased brain-derived neurotrophic factor (BDNF). The present study aims to investigate the effects of the mood stabilizers lithium (Li) and valproate (VPT) in an animal model of bipolar disorder. In the first experiment (acute treatment), rats were administered D-amphetamine (AMPH) or saline for 14 days, and then between day 8 and 14, rats were treated with either Li, VPT or saline. In the second experiment (maintenance treatment), rats were pretreated with Li, VPT or saline, and then between day 8 and 14, rats were administered AMPH or saline. In both experiments, locomotor activity was measured using the open-field test and BDNF levels were measured in rat hippocampus by sandwich-ELISA. Li and VPT reversed AMPH-induced behavioral effects in the open-field test in both experiments. In the first experiment, Li increased BDNF levels in rat hippocampus. In the second experiment, AMPH decreased BDNF levels and Li and VPT increased BDNF levels in rat hippocampus. Our results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600/Anexo, Zip code: 90035-003, Porto Alegre, RS, Brazil.

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    Source

    Life sciences 79:3 2006 Jun 13 pg 281-6

    MeSH

    Affect
    Amphetamine
    Animals
    Antimanic Agents
    Bipolar Disorder
    Brain-Derived Neurotrophic Factor
    Disease Models, Animal
    Hippocampus
    Lithium
    Male
    Rats
    Rats, Wistar
    Valproic Acid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16460767

    Citation

    Frey, Benício N., et al. "Effects of Mood Stabilizers On Hippocampus BDNF Levels in an Animal Model of Mania." Life Sciences, vol. 79, no. 3, 2006, pp. 281-6.
    Frey BN, Andreazza AC, Ceresér KM, et al. Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. Life Sci. 2006;79(3):281-6.
    Frey, B. N., Andreazza, A. C., Ceresér, K. M., Martins, M. R., Valvassori, S. S., Réus, G. Z., ... Kapczinski, F. (2006). Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. Life Sciences, 79(3), pp. 281-6.
    Frey BN, et al. Effects of Mood Stabilizers On Hippocampus BDNF Levels in an Animal Model of Mania. Life Sci. 2006 Jun 13;79(3):281-6. PubMed PMID: 16460767.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. AU - Frey,Benício N, AU - Andreazza,Ana C, AU - Ceresér,Keila M M, AU - Martins,Márcio R, AU - Valvassori,Samira S, AU - Réus,Gislaine Z, AU - Quevedo,João, AU - Kapczinski,Flávio, Y1 - 2006/02/07/ PY - 2005/10/22/received PY - 2005/11/29/revised PY - 2006/01/04/accepted PY - 2006/2/8/pubmed PY - 2006/8/5/medline PY - 2006/2/8/entrez SP - 281 EP - 6 JF - Life sciences JO - Life Sci. VL - 79 IS - 3 N2 - There is an emerging body of data suggesting that mood disorders are associated with decreased brain-derived neurotrophic factor (BDNF). The present study aims to investigate the effects of the mood stabilizers lithium (Li) and valproate (VPT) in an animal model of bipolar disorder. In the first experiment (acute treatment), rats were administered D-amphetamine (AMPH) or saline for 14 days, and then between day 8 and 14, rats were treated with either Li, VPT or saline. In the second experiment (maintenance treatment), rats were pretreated with Li, VPT or saline, and then between day 8 and 14, rats were administered AMPH or saline. In both experiments, locomotor activity was measured using the open-field test and BDNF levels were measured in rat hippocampus by sandwich-ELISA. Li and VPT reversed AMPH-induced behavioral effects in the open-field test in both experiments. In the first experiment, Li increased BDNF levels in rat hippocampus. In the second experiment, AMPH decreased BDNF levels and Li and VPT increased BDNF levels in rat hippocampus. Our results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/16460767/Effects_of_mood_stabilizers_on_hippocampus_BDNF_levels_in_an_animal_model_of_mania_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(06)00030-0 DB - PRIME DP - Unbound Medicine ER -