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The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency.
Haematologica. 2006 Feb; 91(2):231-4.H

Abstract

Treatment of B12 deficiency is important to prevent progressive neurological and/or hematologic disease but requires a secure diagnosis. The aim of this study was to evaluate second line tests of B12 status as prognostic indicators of a hematologic response to vitamin B12 therapy. Forty-nine patients referred with low, serum vitamin B12 concentrations were treated with intramuscular B12 and re-assessed after 3 months. Methylmalonic acid, homocysteine, holotranscobalamin and neutrophil hypersegmentation index were measured before and after treatment. Before treatment 27/49 patients were anemic or macrocytic of whom 15 had a clear hematologic response. All the tests had a similar prognostic accuracy. Symptomatic improvement did not correlate with hematologic response. Supplementary tests of vitamin B12 status were not significantly better than total serum B12 concentration as predictors of a hematologic response to vitamin B12 therapy.

Authors+Show Affiliations

Department of Haematology, University Hospital of Wales, Cardiff CF14 4XN, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16461308

Citation

Goringe, Andrew, et al. "The Limited Value of Methylmalonic Acid, Homocysteine and Holotranscobalamin in the Diagnosis of Early B12 Deficiency." Haematologica, vol. 91, no. 2, 2006, pp. 231-4.
Goringe A, Ellis R, McDowell I, et al. The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. Haematologica. 2006;91(2):231-4.
Goringe, A., Ellis, R., McDowell, I., Vidal-Alaball, J., Jenkins, C., Butler, C., & Worwood, M. (2006). The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. Haematologica, 91(2), 231-4.
Goringe A, et al. The Limited Value of Methylmalonic Acid, Homocysteine and Holotranscobalamin in the Diagnosis of Early B12 Deficiency. Haematologica. 2006;91(2):231-4. PubMed PMID: 16461308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. AU - Goringe,Andrew, AU - Ellis,Richard, AU - McDowell,Ian, AU - Vidal-Alaball,Josep, AU - Jenkins,Christopher, AU - Butler,Christopher, AU - Worwood,Mark, PY - 2006/2/8/pubmed PY - 2006/7/11/medline PY - 2006/2/8/entrez SP - 231 EP - 4 JF - Haematologica JO - Haematologica VL - 91 IS - 2 N2 - Treatment of B12 deficiency is important to prevent progressive neurological and/or hematologic disease but requires a secure diagnosis. The aim of this study was to evaluate second line tests of B12 status as prognostic indicators of a hematologic response to vitamin B12 therapy. Forty-nine patients referred with low, serum vitamin B12 concentrations were treated with intramuscular B12 and re-assessed after 3 months. Methylmalonic acid, homocysteine, holotranscobalamin and neutrophil hypersegmentation index were measured before and after treatment. Before treatment 27/49 patients were anemic or macrocytic of whom 15 had a clear hematologic response. All the tests had a similar prognostic accuracy. Symptomatic improvement did not correlate with hematologic response. Supplementary tests of vitamin B12 status were not significantly better than total serum B12 concentration as predictors of a hematologic response to vitamin B12 therapy. SN - 1592-8721 UR - https://www.unboundmedicine.com/medline/citation/16461308/The_limited_value_of_methylmalonic_acid_homocysteine_and_holotranscobalamin_in_the_diagnosis_of_early_B12_deficiency_ DB - PRIME DP - Unbound Medicine ER -