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Effects of mu-, delta- and kappa-opioid receptor agonists on methamphetamine-induced self-injurious behavior in mice.
Eur J Pharmacol. 2006 Feb 17; 532(1-2):81-7.EJ

Abstract

Opioid receptor agonists can differentially modify the behavioral effects of direct/indirect dopamine receptor agonists, such as methamphetamine, cocaine and apomorphine. However, the effects of opioid receptor agonists on high-dose methamphetamine-induced behavior have not yet been clarified. Therefore, the present study was undertaken to investigate the effects of mu (morphine)-, delta (SNC80)- and kappa (U50,488H)-opioid receptor agonists on methamphetamine-induced self-injurious behavior and locomotor activity in mice. Methamphetamine (20 mg/kg) induced severe self-injurious behavior. In a combination test, some opioid receptor agonists significantly attenuated methamphetamine-induced self-injurious behavior, with potencies in the order morphine>buprenorphine (mu-opioid and kappa-opioid receptor agonist/antagonist) >U50,488H, as maximum effects. These results suggest that the stimulation of mu- and kappa-opioid receptors plays an inhibitory role in high-dose methamphetamine-induced stereotypic self-injurious behavior in mice, without affecting locomotor activity.

Authors+Show Affiliations

Department of Legal Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16464448

Citation

Mori, Tomohisa, et al. "Effects of Mu-, Delta- and Kappa-opioid Receptor Agonists On Methamphetamine-induced Self-injurious Behavior in Mice." European Journal of Pharmacology, vol. 532, no. 1-2, 2006, pp. 81-7.
Mori T, Ito S, Kita T, et al. Effects of mu-, delta- and kappa-opioid receptor agonists on methamphetamine-induced self-injurious behavior in mice. Eur J Pharmacol. 2006;532(1-2):81-7.
Mori, T., Ito, S., Kita, T., Narita, M., Suzuki, T., & Sawaguchi, T. (2006). Effects of mu-, delta- and kappa-opioid receptor agonists on methamphetamine-induced self-injurious behavior in mice. European Journal of Pharmacology, 532(1-2), 81-7.
Mori T, et al. Effects of Mu-, Delta- and Kappa-opioid Receptor Agonists On Methamphetamine-induced Self-injurious Behavior in Mice. Eur J Pharmacol. 2006 Feb 17;532(1-2):81-7. PubMed PMID: 16464448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of mu-, delta- and kappa-opioid receptor agonists on methamphetamine-induced self-injurious behavior in mice. AU - Mori,Tomohisa, AU - Ito,Shinobu, AU - Kita,Taizo, AU - Narita,Minoru, AU - Suzuki,Tsutomu, AU - Sawaguchi,Toshiko, Y1 - 2006/02/07/ PY - 2005/12/02/revised PY - 2005/12/19/accepted PY - 2006/2/9/pubmed PY - 2006/6/3/medline PY - 2006/2/9/entrez SP - 81 EP - 7 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 532 IS - 1-2 N2 - Opioid receptor agonists can differentially modify the behavioral effects of direct/indirect dopamine receptor agonists, such as methamphetamine, cocaine and apomorphine. However, the effects of opioid receptor agonists on high-dose methamphetamine-induced behavior have not yet been clarified. Therefore, the present study was undertaken to investigate the effects of mu (morphine)-, delta (SNC80)- and kappa (U50,488H)-opioid receptor agonists on methamphetamine-induced self-injurious behavior and locomotor activity in mice. Methamphetamine (20 mg/kg) induced severe self-injurious behavior. In a combination test, some opioid receptor agonists significantly attenuated methamphetamine-induced self-injurious behavior, with potencies in the order morphine>buprenorphine (mu-opioid and kappa-opioid receptor agonist/antagonist) >U50,488H, as maximum effects. These results suggest that the stimulation of mu- and kappa-opioid receptors plays an inhibitory role in high-dose methamphetamine-induced stereotypic self-injurious behavior in mice, without affecting locomotor activity. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16464448/Effects_of_mu__delta__and_kappa_opioid_receptor_agonists_on_methamphetamine_induced_self_injurious_behavior_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(05)01345-2 DB - PRIME DP - Unbound Medicine ER -