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The transient receptor potential vanilloid 1: role in airway inflammation and disease.
Eur J Pharmacol. 2006 Mar 08; 533(1-3):207-14.EJ

Abstract

The transient receptor potential vanilloid 1 (TRPV1) is an excitatory cation channel, rather selectively expressed in a subpopulation of nociceptive, primary sensory neurons that promote neurogenic inflammation via neuropeptide release. TRPV1 is activated by noxious temperature, low extracellular pH and diverse lipid derivatives, and is uniquely sensitive to vanilloid molecules, including capsaicin. TRPV1 expression and sensitivity is highly regulated by diverse G protein-coupled and tyrosine kinase receptors. Other exogenous or endogenous chemical agents, including reactive oxygen species, ethanol and hydrogen sulphide sensitize/activate TRPV1. In the airways, TRPV1 agonists cause cough, bronchoconstriction, microvascular leakage, hyperreactivity and hypersecretion. Patients with asthma and chronic obstructive pulmonary disease are more sensitive to the tussive effect of TRPV1 agonists and TRPV1 activation may contribute to respiratory symptoms caused by acidic media present in the airways during asthma exacerbation, gastroesophageal reflux induced asthma or in other conditions. TRPV1 antagonists may be useful in the treatment of these diseases.

Authors+Show Affiliations

Clinical Pharmacology Unit, Department of Critical Care Medicine and Surgery, University of Florence, Italy. pierangelo.geppetti@unifi.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16464449

Citation

Geppetti, Pierangelo, et al. "The Transient Receptor Potential Vanilloid 1: Role in Airway Inflammation and Disease." European Journal of Pharmacology, vol. 533, no. 1-3, 2006, pp. 207-14.
Geppetti P, Materazzi S, Nicoletti P. The transient receptor potential vanilloid 1: role in airway inflammation and disease. Eur J Pharmacol. 2006;533(1-3):207-14.
Geppetti, P., Materazzi, S., & Nicoletti, P. (2006). The transient receptor potential vanilloid 1: role in airway inflammation and disease. European Journal of Pharmacology, 533(1-3), 207-14.
Geppetti P, Materazzi S, Nicoletti P. The Transient Receptor Potential Vanilloid 1: Role in Airway Inflammation and Disease. Eur J Pharmacol. 2006 Mar 8;533(1-3):207-14. PubMed PMID: 16464449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The transient receptor potential vanilloid 1: role in airway inflammation and disease. AU - Geppetti,Pierangelo, AU - Materazzi,Serena, AU - Nicoletti,Paola, Y1 - 2006/02/07/ PY - 2005/12/13/accepted PY - 2006/2/9/pubmed PY - 2006/5/12/medline PY - 2006/2/9/entrez SP - 207 EP - 14 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 533 IS - 1-3 N2 - The transient receptor potential vanilloid 1 (TRPV1) is an excitatory cation channel, rather selectively expressed in a subpopulation of nociceptive, primary sensory neurons that promote neurogenic inflammation via neuropeptide release. TRPV1 is activated by noxious temperature, low extracellular pH and diverse lipid derivatives, and is uniquely sensitive to vanilloid molecules, including capsaicin. TRPV1 expression and sensitivity is highly regulated by diverse G protein-coupled and tyrosine kinase receptors. Other exogenous or endogenous chemical agents, including reactive oxygen species, ethanol and hydrogen sulphide sensitize/activate TRPV1. In the airways, TRPV1 agonists cause cough, bronchoconstriction, microvascular leakage, hyperreactivity and hypersecretion. Patients with asthma and chronic obstructive pulmonary disease are more sensitive to the tussive effect of TRPV1 agonists and TRPV1 activation may contribute to respiratory symptoms caused by acidic media present in the airways during asthma exacerbation, gastroesophageal reflux induced asthma or in other conditions. TRPV1 antagonists may be useful in the treatment of these diseases. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16464449/The_transient_receptor_potential_vanilloid_1:_role_in_airway_inflammation_and_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16464449.ui DB - PRIME DP - Unbound Medicine ER -