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Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients.
Oncol Rep. 2006 Mar; 15(3):595-601.OR

Abstract

C/EBP beta (CCAAT/enhancer binding protein beta) is a transcriptional factor that belongs to the basic region-leucine zipper class DNA-binding proteins and plays a role in cell differentiation and inflammatory reactions. Although high tissue levels of inflammatory cytokines, such as interleukin (IL)-6, IL-8 and transforming growth factor-beta, have been observed in glioma patients, the mechanisms underlying this phenomenon remain to be elucidated. C/EBP beta induces a variety of cytokines and thus may play a role in the pathogenesis of glioma. In this study, we investigated the relationship between C/EBP beta expression, tumor histology, and prognosis in glioma. The expression of C/EBP beta mRNA was examined with quantitative real-time PCR and protein expression was examined with immunohistochemical techniques in 47 glioma tissue samples. Expression of C/EBP beta mRNA and protein was markedly increased in high grade glioma compared with low grade glioma. Patients whose expression of C/EBP beta mRNA and protein in tumor tissue was lower survived longer than those whose expressions were higher. In vitro, C/EBP beta siRNA inhibited glioma cell proliferation and invasion. Moreover, IL-8 production by glioma cells was inhibited by C/EBP beta siRNA transfection. These data suggest that increased expression of C/EBP beta may contribute to the promotion of tumor invasiveness and progression. The data imply that the comparison of C/EBP beta expression could be a prognostic marker for patients with glioma.

Authors+Show Affiliations

Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16465418

Citation

Homma, Jumpei, et al. "Increased Expression of CCAAT/enhancer Binding Protein Beta Correlates With Prognosis in Glioma Patients." Oncology Reports, vol. 15, no. 3, 2006, pp. 595-601.
Homma J, Yamanaka R, Yajima N, et al. Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients. Oncol Rep. 2006;15(3):595-601.
Homma, J., Yamanaka, R., Yajima, N., Tsuchiya, N., Genkai, N., Sano, M., & Tanaka, R. (2006). Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients. Oncology Reports, 15(3), 595-601.
Homma J, et al. Increased Expression of CCAAT/enhancer Binding Protein Beta Correlates With Prognosis in Glioma Patients. Oncol Rep. 2006;15(3):595-601. PubMed PMID: 16465418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients. AU - Homma,Jumpei, AU - Yamanaka,Ryuya, AU - Yajima,Naoki, AU - Tsuchiya,Naoto, AU - Genkai,Nobuyuki, AU - Sano,Masakazu, AU - Tanaka,Ryuichi, PY - 2006/2/9/pubmed PY - 2006/4/14/medline PY - 2006/2/9/entrez SP - 595 EP - 601 JF - Oncology reports JO - Oncol Rep VL - 15 IS - 3 N2 - C/EBP beta (CCAAT/enhancer binding protein beta) is a transcriptional factor that belongs to the basic region-leucine zipper class DNA-binding proteins and plays a role in cell differentiation and inflammatory reactions. Although high tissue levels of inflammatory cytokines, such as interleukin (IL)-6, IL-8 and transforming growth factor-beta, have been observed in glioma patients, the mechanisms underlying this phenomenon remain to be elucidated. C/EBP beta induces a variety of cytokines and thus may play a role in the pathogenesis of glioma. In this study, we investigated the relationship between C/EBP beta expression, tumor histology, and prognosis in glioma. The expression of C/EBP beta mRNA was examined with quantitative real-time PCR and protein expression was examined with immunohistochemical techniques in 47 glioma tissue samples. Expression of C/EBP beta mRNA and protein was markedly increased in high grade glioma compared with low grade glioma. Patients whose expression of C/EBP beta mRNA and protein in tumor tissue was lower survived longer than those whose expressions were higher. In vitro, C/EBP beta siRNA inhibited glioma cell proliferation and invasion. Moreover, IL-8 production by glioma cells was inhibited by C/EBP beta siRNA transfection. These data suggest that increased expression of C/EBP beta may contribute to the promotion of tumor invasiveness and progression. The data imply that the comparison of C/EBP beta expression could be a prognostic marker for patients with glioma. SN - 1021-335X UR - https://www.unboundmedicine.com/medline/citation/16465418/Increased_expression_of_CCAAT/enhancer_binding_protein_beta_correlates_with_prognosis_in_glioma_patients_ L2 - https://www.spandidos-publications.com/or/15/3/595 DB - PRIME DP - Unbound Medicine ER -