Tags

Type your tag names separated by a space and hit enter

Subclinical atherosclerosis in rheumatoid arthritis in India.
J Rheumatol 2006; 33(2):244-7JR

Abstract

OBJECTIVE

Patients with rheumatoid arthritis (RA) have high cardiovascular morbidity and mortality as compared to the general population. Indians are also at increased risk of developing early and severe atherosclerotic coronary artery disease. Carotid intima-media thickness as measured by ultrasound is a validated surrogate marker of atherosclerosis. We studied the prevalence of subclinical atherosclerosis in Indian patients with RA.

METHODS

Common carotid IMT (CCA IMT) was measured at the level of carotid bifurcation along with fasting lipid profile in 57 RA patients and 45 age and sex matched controls. Values of mean CCA IMT above mean + 2 SD of the control group were defined as abnormal IMT. Variables of disease activity and severity were measured in RA patients. Patients and controls with known traditional cardiovascular risk factors were excluded from the study. Student t test and chi-square test for proportion were used for statistical analysis. A logistic regression analysis was done to find out independent predictors of abnormal IMT.

RESULTS

Nineteen RA patients (33.3%) and 2 controls (4.44%) had abnormal IMT values. RA patients had significantly increased mean CCA IMT (0.558 +/- 0.137 mm) as compared to controls (0.416 +/- 0.002 mm; p < 0.0001). Age > or = 42 years, duration of disease > or= 6 years, and tender joint count > or = 5 predicted increased risk of having abnormal CCA IMT in a logistic regression analysis.

CONCLUSION

One-third of Indian RA patients had subclinical atherosclerosis. Age and tender joint count were independent predictors of abnormal CCA IMT.

Authors+Show Affiliations

Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16465654

Citation

Grover, Sundeep, et al. "Subclinical Atherosclerosis in Rheumatoid Arthritis in India." The Journal of Rheumatology, vol. 33, no. 2, 2006, pp. 244-7.
Grover S, Sinha RP, Singh U, et al. Subclinical atherosclerosis in rheumatoid arthritis in India. J Rheumatol. 2006;33(2):244-7.
Grover, S., Sinha, R. P., Singh, U., Tewari, S., Aggarwal, A., & Misra, R. (2006). Subclinical atherosclerosis in rheumatoid arthritis in India. The Journal of Rheumatology, 33(2), pp. 244-7.
Grover S, et al. Subclinical Atherosclerosis in Rheumatoid Arthritis in India. J Rheumatol. 2006;33(2):244-7. PubMed PMID: 16465654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subclinical atherosclerosis in rheumatoid arthritis in India. AU - Grover,Sundeep, AU - Sinha,Ramanand Prasad, AU - Singh,Uttam, AU - Tewari,Satyendra, AU - Aggarwal,Amita, AU - Misra,Ramnath, PY - 2006/2/9/pubmed PY - 2006/5/5/medline PY - 2006/2/9/entrez SP - 244 EP - 7 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 33 IS - 2 N2 - OBJECTIVE: Patients with rheumatoid arthritis (RA) have high cardiovascular morbidity and mortality as compared to the general population. Indians are also at increased risk of developing early and severe atherosclerotic coronary artery disease. Carotid intima-media thickness as measured by ultrasound is a validated surrogate marker of atherosclerosis. We studied the prevalence of subclinical atherosclerosis in Indian patients with RA. METHODS: Common carotid IMT (CCA IMT) was measured at the level of carotid bifurcation along with fasting lipid profile in 57 RA patients and 45 age and sex matched controls. Values of mean CCA IMT above mean + 2 SD of the control group were defined as abnormal IMT. Variables of disease activity and severity were measured in RA patients. Patients and controls with known traditional cardiovascular risk factors were excluded from the study. Student t test and chi-square test for proportion were used for statistical analysis. A logistic regression analysis was done to find out independent predictors of abnormal IMT. RESULTS: Nineteen RA patients (33.3%) and 2 controls (4.44%) had abnormal IMT values. RA patients had significantly increased mean CCA IMT (0.558 +/- 0.137 mm) as compared to controls (0.416 +/- 0.002 mm; p < 0.0001). Age > or = 42 years, duration of disease > or= 6 years, and tender joint count > or = 5 predicted increased risk of having abnormal CCA IMT in a logistic regression analysis. CONCLUSION: One-third of Indian RA patients had subclinical atherosclerosis. Age and tender joint count were independent predictors of abnormal CCA IMT. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/16465654/Subclinical_atherosclerosis_in_rheumatoid_arthritis_in_India_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=16465654 DB - PRIME DP - Unbound Medicine ER -