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Development and application of a high-performance liquid chromatography method using monolithic columns for the analysis of ecstasy tablets.
J Chromatogr A. 2006 Jul 07; 1120(1-2):54-60.JC

Abstract

A rapid and selective HPLC method using monolithic columns was developed for the separation and quantification of the principal amphetamines in ecstasy tablets. Three monolithic (Chromolith RP18e) columns of different lengths (25, 50 and 100 mm) were assessed. Validation studies including linearity, selectivity, precision, accuracy and limit of detection and quantification were carried out using the Chromolith SpeedROD, RP-18e, 50 mm x 4.6 mm column. Column backpressure and van Deemter plots demonstrated that monolithic columns provide higher efficiency at higher flow rates when compared to particulate columns without the loss of peak resolution. Application of the monolithic column to a large number of ecstasy tablets seized in Ireland ensured its suitability for the routine analysis of ecstasy tablets.

Authors+Show Affiliations

Science Research Department, Letterkenny Institute of Technology, Donegal, Ireland. kim_mc_fadden@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16466734

Citation

Mc Fadden, Kim, et al. "Development and Application of a High-performance Liquid Chromatography Method Using Monolithic Columns for the Analysis of Ecstasy Tablets." Journal of Chromatography. A, vol. 1120, no. 1-2, 2006, pp. 54-60.
Mc Fadden K, Gillespie J, Carney B, et al. Development and application of a high-performance liquid chromatography method using monolithic columns for the analysis of ecstasy tablets. J Chromatogr A. 2006;1120(1-2):54-60.
Mc Fadden, K., Gillespie, J., Carney, B., & O'Driscoll, D. (2006). Development and application of a high-performance liquid chromatography method using monolithic columns for the analysis of ecstasy tablets. Journal of Chromatography. A, 1120(1-2), 54-60.
Mc Fadden K, et al. Development and Application of a High-performance Liquid Chromatography Method Using Monolithic Columns for the Analysis of Ecstasy Tablets. J Chromatogr A. 2006 Jul 7;1120(1-2):54-60. PubMed PMID: 16466734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and application of a high-performance liquid chromatography method using monolithic columns for the analysis of ecstasy tablets. AU - Mc Fadden,Kim, AU - Gillespie,John, AU - Carney,Brian, AU - O'Driscoll,Daniel, Y1 - 2006/02/08/ PY - 2005/07/29/received PY - 2006/01/09/revised PY - 2006/01/17/accepted PY - 2006/2/10/pubmed PY - 2006/8/19/medline PY - 2006/2/10/entrez SP - 54 EP - 60 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1120 IS - 1-2 N2 - A rapid and selective HPLC method using monolithic columns was developed for the separation and quantification of the principal amphetamines in ecstasy tablets. Three monolithic (Chromolith RP18e) columns of different lengths (25, 50 and 100 mm) were assessed. Validation studies including linearity, selectivity, precision, accuracy and limit of detection and quantification were carried out using the Chromolith SpeedROD, RP-18e, 50 mm x 4.6 mm column. Column backpressure and van Deemter plots demonstrated that monolithic columns provide higher efficiency at higher flow rates when compared to particulate columns without the loss of peak resolution. Application of the monolithic column to a large number of ecstasy tablets seized in Ireland ensured its suitability for the routine analysis of ecstasy tablets. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/16466734/Development_and_application_of_a_high_performance_liquid_chromatography_method_using_monolithic_columns_for_the_analysis_of_ecstasy_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(06)00203-2 DB - PRIME DP - Unbound Medicine ER -