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Metaplastic carcinoma of the breast: a clinicopathological review.
J Clin Pathol. 2006 Oct; 59(10):1079-83.JC

Abstract

BACKGROUND

Mammary metaplastic carcinoma encompasses epithelial-only carcinoma (high-grade adenosquamous carcinoma or pure squamous cell carcinoma), biphasic epithelial and sarcomatoid carcinoma and monophasic spindle cell carcinoma.

AIM

To evaluate the clinicopathological features of a large series of 34 metaplastic carcinomas.

METHODS

10 epithelial-only, 14 biphasic and 10 monophasic metaplastic carcinomas were assessed for nuclear grade, hormone receptor status, HER2/neu (cerbB2) oncogene expression, Ki-67 and p53, lymph node status and recurrence on follow-up.

RESULTS

Intermediate to high nuclear grade were assessed in most (33/34) tumours. Oestrogen and progesterone receptors were negative in 8 of 10 epithelial-only, all 14 biphasic, and 9 of 10 monophasic tumours, cerbB2 was negative in 7 of 10 epithelial-only, all 14 biphasic and 8 of 10 monophasic tumours. Ki-67 was found to be positive in 6 of 10 epithelial-only, 6 of 14 biphasic, and 7 of 10 monophasic tumours, whereas p53 was positive in 6 of 10 epithelial-only, 7 of 14 biphasic, and 8 of 10 monophasic tumours. Lymph node metastases were seen in 7 of 7 epithelial-only, 7 of 11 biphasic, and 3 of 7 monophasic tumours. Recurrences were seen in 4 of 7 epithelial-only, 8 of 9 biphasic, and 4 of 9 monophasic tumours.

CONCLUSIONS

All three subtypes of metaplastic carcinoma are known to behave aggressively, and should be differentiated from the low-grade fibromatosis-like metaplastic carcinoma, which does not metastasize. Oncological treatment options may be limited by the frequently negative status of hormonal receptor and cerbB2.

Authors+Show Affiliations

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong. garytse@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16467167

Citation

Tse, G M., et al. "Metaplastic Carcinoma of the Breast: a Clinicopathological Review." Journal of Clinical Pathology, vol. 59, no. 10, 2006, pp. 1079-83.
Tse GM, Tan PH, Putti TC, et al. Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 2006;59(10):1079-83.
Tse, G. M., Tan, P. H., Putti, T. C., Lui, P. C., Chaiwun, B., & Law, B. K. (2006). Metaplastic carcinoma of the breast: a clinicopathological review. Journal of Clinical Pathology, 59(10), 1079-83.
Tse GM, et al. Metaplastic Carcinoma of the Breast: a Clinicopathological Review. J Clin Pathol. 2006;59(10):1079-83. PubMed PMID: 16467167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metaplastic carcinoma of the breast: a clinicopathological review. AU - Tse,G M, AU - Tan,P H, AU - Putti,T C, AU - Lui,P C W, AU - Chaiwun,B, AU - Law,B K B, Y1 - 2006/02/07/ PY - 2006/2/10/pubmed PY - 2006/12/9/medline PY - 2006/2/10/entrez SP - 1079 EP - 83 JF - Journal of clinical pathology JO - J Clin Pathol VL - 59 IS - 10 N2 - BACKGROUND: Mammary metaplastic carcinoma encompasses epithelial-only carcinoma (high-grade adenosquamous carcinoma or pure squamous cell carcinoma), biphasic epithelial and sarcomatoid carcinoma and monophasic spindle cell carcinoma. AIM: To evaluate the clinicopathological features of a large series of 34 metaplastic carcinomas. METHODS: 10 epithelial-only, 14 biphasic and 10 monophasic metaplastic carcinomas were assessed for nuclear grade, hormone receptor status, HER2/neu (cerbB2) oncogene expression, Ki-67 and p53, lymph node status and recurrence on follow-up. RESULTS: Intermediate to high nuclear grade were assessed in most (33/34) tumours. Oestrogen and progesterone receptors were negative in 8 of 10 epithelial-only, all 14 biphasic, and 9 of 10 monophasic tumours, cerbB2 was negative in 7 of 10 epithelial-only, all 14 biphasic and 8 of 10 monophasic tumours. Ki-67 was found to be positive in 6 of 10 epithelial-only, 6 of 14 biphasic, and 7 of 10 monophasic tumours, whereas p53 was positive in 6 of 10 epithelial-only, 7 of 14 biphasic, and 8 of 10 monophasic tumours. Lymph node metastases were seen in 7 of 7 epithelial-only, 7 of 11 biphasic, and 3 of 7 monophasic tumours. Recurrences were seen in 4 of 7 epithelial-only, 8 of 9 biphasic, and 4 of 9 monophasic tumours. CONCLUSIONS: All three subtypes of metaplastic carcinoma are known to behave aggressively, and should be differentiated from the low-grade fibromatosis-like metaplastic carcinoma, which does not metastasize. Oncological treatment options may be limited by the frequently negative status of hormonal receptor and cerbB2. SN - 0021-9746 UR - https://www.unboundmedicine.com/medline/citation/16467167/Metaplastic_carcinoma_of_the_breast:_a_clinicopathological_review_ L2 - https://jcp.bmj.com/lookup/pmidlookup?view=long&pmid=16467167 DB - PRIME DP - Unbound Medicine ER -