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Zn(pybox)-complex-catalyzed asymmetric aqueous Mukaiyama-aldol reactions.
J Org Chem. 2006 Feb 17; 71(4):1317-21.JO

Abstract

Catalytic asymmetric aldol reactions in aqueous media have been developed using chiral zinc complex. The aldol products have been obtained in high yields, high diastereocontrol, and good level of enantioselectivity. Various aromatic and alpha,beta-unsaturated aldehydes and silyl enol ethers derived from ketones can be employed in this reaction to provide the aldol adducts in good to high yield. The elaborated catalytic system has been found as selective for aliphatic aldehydes as well.

Authors+Show Affiliations

Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16468777

Citation

Jankowska, Joanna, and Jacek Mlynarski. "Zn(pybox)-complex-catalyzed Asymmetric Aqueous Mukaiyama-aldol Reactions." The Journal of Organic Chemistry, vol. 71, no. 4, 2006, pp. 1317-21.
Jankowska J, Mlynarski J. Zn(pybox)-complex-catalyzed asymmetric aqueous Mukaiyama-aldol reactions. J Org Chem. 2006;71(4):1317-21.
Jankowska, J., & Mlynarski, J. (2006). Zn(pybox)-complex-catalyzed asymmetric aqueous Mukaiyama-aldol reactions. The Journal of Organic Chemistry, 71(4), 1317-21.
Jankowska J, Mlynarski J. Zn(pybox)-complex-catalyzed Asymmetric Aqueous Mukaiyama-aldol Reactions. J Org Chem. 2006 Feb 17;71(4):1317-21. PubMed PMID: 16468777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zn(pybox)-complex-catalyzed asymmetric aqueous Mukaiyama-aldol reactions. AU - Jankowska,Joanna, AU - Mlynarski,Jacek, PY - 2006/2/14/pubmed PY - 2006/2/14/medline PY - 2006/2/14/entrez SP - 1317 EP - 21 JF - The Journal of organic chemistry JO - J Org Chem VL - 71 IS - 4 N2 - Catalytic asymmetric aldol reactions in aqueous media have been developed using chiral zinc complex. The aldol products have been obtained in high yields, high diastereocontrol, and good level of enantioselectivity. Various aromatic and alpha,beta-unsaturated aldehydes and silyl enol ethers derived from ketones can be employed in this reaction to provide the aldol adducts in good to high yield. The elaborated catalytic system has been found as selective for aliphatic aldehydes as well. SN - 0022-3263 UR - https://www.unboundmedicine.com/medline/citation/16468777/Zn_pybox__complex_catalyzed_asymmetric_aqueous_Mukaiyama_aldol_reactions_ L2 - https://doi.org/10.1021/jo0514568 DB - PRIME DP - Unbound Medicine ER -
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