Zn(pybox)-complex-catalyzed asymmetric aqueous Mukaiyama-aldol reactions.J Org Chem. 2006 Feb 17; 71(4):1317-21.JO
Catalytic asymmetric aldol reactions in aqueous media have been developed using chiral zinc complex. The aldol products have been obtained in high yields, high diastereocontrol, and good level of enantioselectivity. Various aromatic and alpha,beta-unsaturated aldehydes and silyl enol ethers derived from ketones can be employed in this reaction to provide the aldol adducts in good to high yield. The elaborated catalytic system has been found as selective for aliphatic aldehydes as well.