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Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery.
Obes Surg 2006; 16(2):183-8OS

Abstract

BACKGROUND

In patients with morbid obesity selected for bariatric surgery, previous studies have shown a prevalence of NASH varying from 2.6% to 91%. The prevalence of NASH and extensive fibrosis were studied in a prospective cohort of patients with morbid obesity requiring bariatric surgery, to identify predictive factors of NASH.

METHODS

From July 01 to Sept 02, every patient requiring bariatric surgery had a liver biopsy. The diagnosis of NASH was established using Lee's criteria.

RESULTS

92 patients (85 women, age 38 +/- SEM 11 years) were analyzed. Mean BMI was 45.7 +/- 5.1 kg/m2. 35 patients had lobular inflammation. 9 patients had steatosis associated with lobular necrotic and inflammatory foci and ballooning degeneration or pericellular fibrosis. No cirrhosis or extensive fibrosis was evidenced. The prevalence of NASH in this population was 9.8%. Waist/hips ratio and BMI were independent predictors of lobular inflammation, but only BMI was an independent factor of NASH in multivariate analysis.

CONCLUSION

In this prospective cohort of patients at bariatric surgery, the prevalence of NASH was 9.8%. BMI was the only predictive factor for NASH.

Authors+Show Affiliations

Service d'Hépato-Gastroentérologie, AP-HP Hôpital Louis Mourier, Colombes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16469221

Citation

Harnois, Florence, et al. "Prevalence and Predictive Factors of Non-alcoholic Steatohepatitis (NASH) in Morbidly Obese Patients Undergoing Bariatric Surgery." Obesity Surgery, vol. 16, no. 2, 2006, pp. 183-8.
Harnois F, Msika S, Sabaté JM, et al. Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery. Obes Surg. 2006;16(2):183-8.
Harnois, F., Msika, S., Sabaté, J. M., Mechler, C., Jouet, P., Barge, J., & Coffin, B. (2006). Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery. Obesity Surgery, 16(2), pp. 183-8.
Harnois F, et al. Prevalence and Predictive Factors of Non-alcoholic Steatohepatitis (NASH) in Morbidly Obese Patients Undergoing Bariatric Surgery. Obes Surg. 2006;16(2):183-8. PubMed PMID: 16469221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery. AU - Harnois,Florence, AU - Msika,Simon, AU - Sabaté,Jean-Marc, AU - Mechler,Charlotte, AU - Jouet,Pauline, AU - Barge,Jeanine, AU - Coffin,Benoit, PY - 2006/2/14/pubmed PY - 2006/6/10/medline PY - 2006/2/14/entrez SP - 183 EP - 8 JF - Obesity surgery JO - Obes Surg VL - 16 IS - 2 N2 - BACKGROUND: In patients with morbid obesity selected for bariatric surgery, previous studies have shown a prevalence of NASH varying from 2.6% to 91%. The prevalence of NASH and extensive fibrosis were studied in a prospective cohort of patients with morbid obesity requiring bariatric surgery, to identify predictive factors of NASH. METHODS: From July 01 to Sept 02, every patient requiring bariatric surgery had a liver biopsy. The diagnosis of NASH was established using Lee's criteria. RESULTS: 92 patients (85 women, age 38 +/- SEM 11 years) were analyzed. Mean BMI was 45.7 +/- 5.1 kg/m2. 35 patients had lobular inflammation. 9 patients had steatosis associated with lobular necrotic and inflammatory foci and ballooning degeneration or pericellular fibrosis. No cirrhosis or extensive fibrosis was evidenced. The prevalence of NASH in this population was 9.8%. Waist/hips ratio and BMI were independent predictors of lobular inflammation, but only BMI was an independent factor of NASH in multivariate analysis. CONCLUSION: In this prospective cohort of patients at bariatric surgery, the prevalence of NASH was 9.8%. BMI was the only predictive factor for NASH. SN - 0960-8923 UR - https://www.unboundmedicine.com/medline/citation/16469221/Prevalence_and_predictive_factors_of_non_alcoholic_steatohepatitis__NASH__in_morbidly_obese_patients_undergoing_bariatric_surgery_ L2 - https://dx.doi.org/10.1381/096089206775565122 DB - PRIME DP - Unbound Medicine ER -