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Mimivirus and the emerging concept of "giant" virus.
Virus Res. 2006 Apr; 117(1):133-44.VR

Abstract

The recently discovered Acanthamoeba polyphaga Mimivirus is the largest known DNA virus. Its particle size (750 nm), genome length (1.2 million bp) and large gene repertoire (911 protein coding genes) blur the established boundaries between viruses and parasitic cellular organisms. In addition, the analysis of its genome sequence identified many types of genes never before encountered in a virus, including aminoacyl-tRNA synthetases and other central components of the translation machinery previously thought to be the signature of cellular organisms. In this article, we examine how the finding of such a giant virus might durably influence the way we look at microbial biodiversity, and lead us to revise the classification of microbial domains and life forms. We propose to introduce the word "girus" to recognize the intermediate status of these giant DNA viruses, the genome complexity of which makes them closer to small parasitic prokaryotes than to regular viruses.

Authors+Show Affiliations

Information Génomique et Structurale, CNRS UPR 2589, IBSM, Parc Scientifique de Luminy, 163 Avenue de Luminy, Case 934, 13288 Marseille Cedex 9, France. Jean-Michel.Claverie@igs.cnrs-mrs.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16469402

Citation

Claverie, Jean-Michel, et al. "Mimivirus and the Emerging Concept of "giant" Virus." Virus Research, vol. 117, no. 1, 2006, pp. 133-44.
Claverie JM, Ogata H, Audic S, et al. Mimivirus and the emerging concept of "giant" virus. Virus Res. 2006;117(1):133-44.
Claverie, J. M., Ogata, H., Audic, S., Abergel, C., Suhre, K., & Fournier, P. E. (2006). Mimivirus and the emerging concept of "giant" virus. Virus Research, 117(1), 133-44.
Claverie JM, et al. Mimivirus and the Emerging Concept of "giant" Virus. Virus Res. 2006;117(1):133-44. PubMed PMID: 16469402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mimivirus and the emerging concept of "giant" virus. AU - Claverie,Jean-Michel, AU - Ogata,Hiroyuki, AU - Audic,Stéphane, AU - Abergel,Chantal, AU - Suhre,Karsten, AU - Fournier,Pierre-Edouard, Y1 - 2006/02/15/ PY - 2005/09/02/received PY - 2006/01/06/revised PY - 2006/01/09/accepted PY - 2006/2/14/pubmed PY - 2006/6/13/medline PY - 2006/2/14/entrez SP - 133 EP - 44 JF - Virus research JO - Virus Res VL - 117 IS - 1 N2 - The recently discovered Acanthamoeba polyphaga Mimivirus is the largest known DNA virus. Its particle size (750 nm), genome length (1.2 million bp) and large gene repertoire (911 protein coding genes) blur the established boundaries between viruses and parasitic cellular organisms. In addition, the analysis of its genome sequence identified many types of genes never before encountered in a virus, including aminoacyl-tRNA synthetases and other central components of the translation machinery previously thought to be the signature of cellular organisms. In this article, we examine how the finding of such a giant virus might durably influence the way we look at microbial biodiversity, and lead us to revise the classification of microbial domains and life forms. We propose to introduce the word "girus" to recognize the intermediate status of these giant DNA viruses, the genome complexity of which makes them closer to small parasitic prokaryotes than to regular viruses. SN - 0168-1702 UR - https://www.unboundmedicine.com/medline/citation/16469402/Mimivirus_and_the_emerging_concept_of_"giant"_virus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(06)00027-X DB - PRIME DP - Unbound Medicine ER -