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Measurement of the surface energy of lubricated pharmaceutical powders by inverse gas chromatography.
Int J Pharm. 2006 Apr 07; 312(1-2):158-65.IJ

Abstract

The objective of the study was to determine whether lubrication of pharmaceutical powders with magnesium stearate (MgSt) results in a change in the surface energy of the powder, and to assess whether surface energy changes, if any, are correlated to lubricant concentration and blend time. The surface energies of microcrystalline cellulose (MCC), lactose, and blends of each material with MgSt, prepared at a range of concentrations and blending times were measured using inverse gas chromatography. The physical distribution of MgSt in the blend was mapped by energy dispersive spectrometry. Overall, there was a reduction in the dispersive surface energy of MCC-MgSt blends with increase in MgSt concentration, that was attributed to increasing coverage of the high-energy sites on microcrystalline cellulose by magnesium stearate. MgSt concentration had a larger effect on dispersive energy than the blending time of the powder with lubricant. X-ray maps of blend samples indicated a heterogeneous distribution of the lubricant in the blend and on the excipient particles. Measurement of the specific component of surface energy indicated that MgSt interacts with excipient powders through non-specific forces rather than acid-base interactions. No distinction among lactose-MgSt blends could be made on the basis of dispersive energy because of similar surface energies of the native materials.

Authors+Show Affiliations

Swaminathan V
Pfizer Global R&D, Groton Laboratories, Groton, CT 06340, USA. vidya.swaminathan@pfizer.com
Cobb J
No affiliation info available
Saracovan I
No affiliation info available

MeSH

CelluloseChromatography, GasExcipientsLactoseLubricationPowdersStearic AcidsSurface Properties

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16469458

Citation

Swaminathan, Vidya, et al. "Measurement of the Surface Energy of Lubricated Pharmaceutical Powders By Inverse Gas Chromatography." International Journal of Pharmaceutics, vol. 312, no. 1-2, 2006, pp. 158-65.
Swaminathan V, Cobb J, Saracovan I. Measurement of the surface energy of lubricated pharmaceutical powders by inverse gas chromatography. Int J Pharm. 2006;312(1-2):158-65.
Swaminathan, V., Cobb, J., & Saracovan, I. (2006). Measurement of the surface energy of lubricated pharmaceutical powders by inverse gas chromatography. International Journal of Pharmaceutics, 312(1-2), 158-65.
Swaminathan V, Cobb J, Saracovan I. Measurement of the Surface Energy of Lubricated Pharmaceutical Powders By Inverse Gas Chromatography. Int J Pharm. 2006 Apr 7;312(1-2):158-65. PubMed PMID: 16469458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of the surface energy of lubricated pharmaceutical powders by inverse gas chromatography. AU - Swaminathan,Vidya, AU - Cobb,Jaclyn, AU - Saracovan,Ilie, Y1 - 2006/02/15/ PY - 2005/08/29/received PY - 2006/01/09/revised PY - 2006/01/10/accepted PY - 2006/2/14/pubmed PY - 2006/8/30/medline PY - 2006/2/14/entrez SP - 158 EP - 65 JF - International journal of pharmaceutics JO - Int J Pharm VL - 312 IS - 1-2 N2 - The objective of the study was to determine whether lubrication of pharmaceutical powders with magnesium stearate (MgSt) results in a change in the surface energy of the powder, and to assess whether surface energy changes, if any, are correlated to lubricant concentration and blend time. The surface energies of microcrystalline cellulose (MCC), lactose, and blends of each material with MgSt, prepared at a range of concentrations and blending times were measured using inverse gas chromatography. The physical distribution of MgSt in the blend was mapped by energy dispersive spectrometry. Overall, there was a reduction in the dispersive surface energy of MCC-MgSt blends with increase in MgSt concentration, that was attributed to increasing coverage of the high-energy sites on microcrystalline cellulose by magnesium stearate. MgSt concentration had a larger effect on dispersive energy than the blending time of the powder with lubricant. X-ray maps of blend samples indicated a heterogeneous distribution of the lubricant in the blend and on the excipient particles. Measurement of the specific component of surface energy indicated that MgSt interacts with excipient powders through non-specific forces rather than acid-base interactions. No distinction among lactose-MgSt blends could be made on the basis of dispersive energy because of similar surface energies of the native materials. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/16469458/Measurement_of_the_surface_energy_of_lubricated_pharmaceutical_powders_by_inverse_gas_chromatography_ DB - PRIME DP - Unbound Medicine ER -