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Advances and perspectives in the genetics of inflammatory bowel diseases.
Clin Gastroenterol Hepatol 2006; 4(2):143-51CG

Abstract

Several clinical and biological phenotypes define complex diseases such as inflammatory bowel disease (IBD). There is a critical role of the caspase recruitment domain protein 15/nucleotide-binding oligomerization protein 2-dependent (CARD15-NOD2) sensing of bacterial cell wall components in health and disease. The current etiologic model for IBD emphasizes an interaction between susceptibility and modifier genes along with environmental factors. Together, these lead to disease progression. However, further work should clarify the pathophysiological mechanisms leading to IBD and how innate immune signaling confers susceptibility to intestinal inflammation. This is a prerequisite for rational clinical management of IBD. Genetic, functional, serologic testing and development of therapeutics in IBD are discussed.

Authors+Show Affiliations

INSERM 0114, Hôpital Swynghedauw, Rue A. Verhaeghe, F-59037 Lille, France. m-chamaillard@chru-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16469672

Citation

Chamaillard, Mathias, et al. "Advances and Perspectives in the Genetics of Inflammatory Bowel Diseases." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 4, no. 2, 2006, pp. 143-51.
Chamaillard M, Iacob R, Desreumaux P, et al. Advances and perspectives in the genetics of inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2006;4(2):143-51.
Chamaillard, M., Iacob, R., Desreumaux, P., & Colombel, J. F. (2006). Advances and perspectives in the genetics of inflammatory bowel diseases. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 4(2), pp. 143-51.
Chamaillard M, et al. Advances and Perspectives in the Genetics of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2006;4(2):143-51. PubMed PMID: 16469672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances and perspectives in the genetics of inflammatory bowel diseases. AU - Chamaillard,Mathias, AU - Iacob,Razvan, AU - Desreumaux,Pierre, AU - Colombel,Jean-Frederic, PY - 2006/2/14/pubmed PY - 2006/6/7/medline PY - 2006/2/14/entrez SP - 143 EP - 51 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 4 IS - 2 N2 - Several clinical and biological phenotypes define complex diseases such as inflammatory bowel disease (IBD). There is a critical role of the caspase recruitment domain protein 15/nucleotide-binding oligomerization protein 2-dependent (CARD15-NOD2) sensing of bacterial cell wall components in health and disease. The current etiologic model for IBD emphasizes an interaction between susceptibility and modifier genes along with environmental factors. Together, these lead to disease progression. However, further work should clarify the pathophysiological mechanisms leading to IBD and how innate immune signaling confers susceptibility to intestinal inflammation. This is a prerequisite for rational clinical management of IBD. Genetic, functional, serologic testing and development of therapeutics in IBD are discussed. SN - 1542-3565 UR - https://www.unboundmedicine.com/medline/citation/16469672/Advances_and_perspectives_in_the_genetics_of_inflammatory_bowel_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(05)01096-7 DB - PRIME DP - Unbound Medicine ER -