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Advances and perspectives in the genetics of inflammatory bowel diseases.

Abstract

Several clinical and biological phenotypes define complex diseases such as inflammatory bowel disease (IBD). There is a critical role of the caspase recruitment domain protein 15/nucleotide-binding oligomerization protein 2-dependent (CARD15-NOD2) sensing of bacterial cell wall components in health and disease. The current etiologic model for IBD emphasizes an interaction between susceptibility and modifier genes along with environmental factors. Together, these lead to disease progression. However, further work should clarify the pathophysiological mechanisms leading to IBD and how innate immune signaling confers susceptibility to intestinal inflammation. This is a prerequisite for rational clinical management of IBD. Genetic, functional, serologic testing and development of therapeutics in IBD are discussed.

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  • Authors+Show Affiliations

    ,

    INSERM 0114, Hôpital Swynghedauw, Rue A. Verhaeghe, F-59037 Lille, France. m-chamaillard@chru-lille.fr

    , ,

    Source

    MeSH

    Crohn Disease
    Genetic Predisposition to Disease
    Humans
    Inflammatory Bowel Diseases
    Intracellular Signaling Peptides and Proteins
    Nod2 Signaling Adaptor Protein

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16469672

    Citation

    Chamaillard, Mathias, et al. "Advances and Perspectives in the Genetics of Inflammatory Bowel Diseases." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 4, no. 2, 2006, pp. 143-51.
    Chamaillard M, Iacob R, Desreumaux P, et al. Advances and perspectives in the genetics of inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2006;4(2):143-51.
    Chamaillard, M., Iacob, R., Desreumaux, P., & Colombel, J. F. (2006). Advances and perspectives in the genetics of inflammatory bowel diseases. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 4(2), pp. 143-51.
    Chamaillard M, et al. Advances and Perspectives in the Genetics of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2006;4(2):143-51. PubMed PMID: 16469672.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Advances and perspectives in the genetics of inflammatory bowel diseases. AU - Chamaillard,Mathias, AU - Iacob,Razvan, AU - Desreumaux,Pierre, AU - Colombel,Jean-Frederic, PY - 2006/2/14/pubmed PY - 2006/6/7/medline PY - 2006/2/14/entrez SP - 143 EP - 51 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 4 IS - 2 N2 - Several clinical and biological phenotypes define complex diseases such as inflammatory bowel disease (IBD). There is a critical role of the caspase recruitment domain protein 15/nucleotide-binding oligomerization protein 2-dependent (CARD15-NOD2) sensing of bacterial cell wall components in health and disease. The current etiologic model for IBD emphasizes an interaction between susceptibility and modifier genes along with environmental factors. Together, these lead to disease progression. However, further work should clarify the pathophysiological mechanisms leading to IBD and how innate immune signaling confers susceptibility to intestinal inflammation. This is a prerequisite for rational clinical management of IBD. Genetic, functional, serologic testing and development of therapeutics in IBD are discussed. SN - 1542-3565 UR - https://www.unboundmedicine.com/medline/citation/16469672/Advances_and_perspectives_in_the_genetics_of_inflammatory_bowel_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(05)01096-7 DB - PRIME DP - Unbound Medicine ER -