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Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men.
Am J Clin Nutr. 2006 Feb; 83(2):331-42.AJ

Abstract

BACKGROUND

Increasing intakes of long-chain n-3 polyunsaturated fatty acids (PUFAs) can decrease markers of immunity. However, dose- and age-related responses have not been identified.

OBJECTIVE

The objective was to determine the effects of different amounts of eicosapentaenoic acid (EPA) on innate immune outcomes in young and older males.

DESIGN

In a controlled, double-blind study, healthy young and older men consumed 1 of 4 supplements provided as capsules: placebo (corn oil) or different amounts of an oil providing 1.35, 2.7, or 4.05 g EPA/d for 12 wk. Blood samples were collected at baseline and after 12 wk.

RESULTS

EPA was incorporated in a linear dose-response fashion into plasma and mononuclear cell (MNC) phospholipids; incorporation was greater in the older men. EPA treatment did not alter neutrophil or monocyte phagocytosis, monocyte respiratory burst, or the production of inflammatory cytokines by MNCs in the young or older men. EPA treatment caused a dose-dependent decrease in neutrophil respiratory burst only in the older men. Increased incorporation of EPA into plasma or MNC phospholipids was associated with decreased production of prostaglandin E2 by MNCs from both young and older men.

CONCLUSIONS

Older subjects incorporate EPA into plasma and MNC phospholipids more readily than do younger subjects. Other than prostaglandin E2 production, innate immune responses in young subjects are not affected by an EPA intake of < or =4.05 g/d. Older subjects are more sensitive to the immunologic effects of EPA, and the neutrophil respiratory burst is lower at higher EPA intakes.

Authors+Show Affiliations

The Rowett Research Institute, Aberdeen, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16469992

Citation

Rees, Dinka, et al. "Dose-related Effects of Eicosapentaenoic Acid On Innate Immune Function in Healthy Humans: a Comparison of Young and Older Men." The American Journal of Clinical Nutrition, vol. 83, no. 2, 2006, pp. 331-42.
Rees D, Miles EA, Banerjee T, et al. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am J Clin Nutr. 2006;83(2):331-42.
Rees, D., Miles, E. A., Banerjee, T., Wells, S. J., Roynette, C. E., Wahle, K. W., & Calder, P. C. (2006). Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. The American Journal of Clinical Nutrition, 83(2), 331-42.
Rees D, et al. Dose-related Effects of Eicosapentaenoic Acid On Innate Immune Function in Healthy Humans: a Comparison of Young and Older Men. Am J Clin Nutr. 2006;83(2):331-42. PubMed PMID: 16469992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. AU - Rees,Dinka, AU - Miles,Elizabeth A, AU - Banerjee,Tapati, AU - Wells,Solenne J, AU - Roynette,Catherine E, AU - Wahle,Klaus Wj, AU - Calder,Philip C, PY - 2006/2/14/pubmed PY - 2006/3/8/medline PY - 2006/2/14/entrez SP - 331 EP - 42 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 83 IS - 2 N2 - BACKGROUND: Increasing intakes of long-chain n-3 polyunsaturated fatty acids (PUFAs) can decrease markers of immunity. However, dose- and age-related responses have not been identified. OBJECTIVE: The objective was to determine the effects of different amounts of eicosapentaenoic acid (EPA) on innate immune outcomes in young and older males. DESIGN: In a controlled, double-blind study, healthy young and older men consumed 1 of 4 supplements provided as capsules: placebo (corn oil) or different amounts of an oil providing 1.35, 2.7, or 4.05 g EPA/d for 12 wk. Blood samples were collected at baseline and after 12 wk. RESULTS: EPA was incorporated in a linear dose-response fashion into plasma and mononuclear cell (MNC) phospholipids; incorporation was greater in the older men. EPA treatment did not alter neutrophil or monocyte phagocytosis, monocyte respiratory burst, or the production of inflammatory cytokines by MNCs in the young or older men. EPA treatment caused a dose-dependent decrease in neutrophil respiratory burst only in the older men. Increased incorporation of EPA into plasma or MNC phospholipids was associated with decreased production of prostaglandin E2 by MNCs from both young and older men. CONCLUSIONS: Older subjects incorporate EPA into plasma and MNC phospholipids more readily than do younger subjects. Other than prostaglandin E2 production, innate immune responses in young subjects are not affected by an EPA intake of < or =4.05 g/d. Older subjects are more sensitive to the immunologic effects of EPA, and the neutrophil respiratory burst is lower at higher EPA intakes. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16469992/Dose_related_effects_of_eicosapentaenoic_acid_on_innate_immune_function_in_healthy_humans:_a_comparison_of_young_and_older_men_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/83.2.331 DB - PRIME DP - Unbound Medicine ER -