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Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin.
Am J Clin Nutr 2006; 83(2):380-6AJ

Abstract

BACKGROUND

Vitamin K deficiency is associated with low bone mineral density and increased risk of bone fracture. Phylloquinone (K1) and menaquinone 4 (MK-4) and 7 (MK-7) are generally observed in human plasma; however, data are limited on their circulating concentrations and their associations with bone metabolism or with gamma-carboxylation of the osteocalcin molecule.

OBJECTIVES

The objectives were to measure the circulating concentrations of K1, MK-4, and MK-7 in women and to ascertain whether each form of vitamin K is significantly associated with bone metabolism.

DESIGN

Plasma concentrations of K1, MK-4, MK-7, undercarboxylated osteocalcin (ucOC; measured by using the new electrochemiluminescence immunoassay), intact osteocalcin (iOC), calcium, and phosphorus; bone-derived alkaline phosphatase activity; and concentrations of urinary creatinine, N-terminal telopeptide, and deoxypyridinoline were measured in healthy women (n = 396).

RESULTS

On average, MK-7 and MK-4 were the highest and lowest, respectively, of the 3 vitamers in all age groups. K1 and MK-7 correlated inversely with ucOC, but associations between nutritional basal concentration of MK-4 and ucOC were not observed. Multiple regression analysis indicated that not only K1 and MK-7 concentrations but also age were independently correlated with ucOC concentration and the ratio of ucOC to iOC. The plasma K1 or MK-7 concentration required to minimize the ucOC concentration was highest in the group aged > or =70 y, and it decreased progressively for each of the younger age groups.

CONCLUSIONS

The definite role of ucOC remains unclear. However, if submaximal gamma-carboxylation is related to the prevention of fracture or bone mineral loss, circulating vitamin K concentrations in elderly people should be kept higher than those in young people.

Authors+Show Affiliations

Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16469998

Citation

Tsugawa, Naoko, et al. "Vitamin K Status of Healthy Japanese Women: Age-related Vitamin K Requirement for Gamma-carboxylation of Osteocalcin." The American Journal of Clinical Nutrition, vol. 83, no. 2, 2006, pp. 380-6.
Tsugawa N, Shiraki M, Suhara Y, et al. Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr. 2006;83(2):380-6.
Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Tanaka, K., & Okano, T. (2006). Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. The American Journal of Clinical Nutrition, 83(2), pp. 380-6.
Tsugawa N, et al. Vitamin K Status of Healthy Japanese Women: Age-related Vitamin K Requirement for Gamma-carboxylation of Osteocalcin. Am J Clin Nutr. 2006;83(2):380-6. PubMed PMID: 16469998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. AU - Tsugawa,Naoko, AU - Shiraki,Masataka, AU - Suhara,Yoshitomo, AU - Kamao,Maya, AU - Tanaka,Kiyoshi, AU - Okano,Toshio, PY - 2006/2/14/pubmed PY - 2006/3/8/medline PY - 2006/2/14/entrez SP - 380 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 83 IS - 2 N2 - BACKGROUND: Vitamin K deficiency is associated with low bone mineral density and increased risk of bone fracture. Phylloquinone (K1) and menaquinone 4 (MK-4) and 7 (MK-7) are generally observed in human plasma; however, data are limited on their circulating concentrations and their associations with bone metabolism or with gamma-carboxylation of the osteocalcin molecule. OBJECTIVES: The objectives were to measure the circulating concentrations of K1, MK-4, and MK-7 in women and to ascertain whether each form of vitamin K is significantly associated with bone metabolism. DESIGN: Plasma concentrations of K1, MK-4, MK-7, undercarboxylated osteocalcin (ucOC; measured by using the new electrochemiluminescence immunoassay), intact osteocalcin (iOC), calcium, and phosphorus; bone-derived alkaline phosphatase activity; and concentrations of urinary creatinine, N-terminal telopeptide, and deoxypyridinoline were measured in healthy women (n = 396). RESULTS: On average, MK-7 and MK-4 were the highest and lowest, respectively, of the 3 vitamers in all age groups. K1 and MK-7 correlated inversely with ucOC, but associations between nutritional basal concentration of MK-4 and ucOC were not observed. Multiple regression analysis indicated that not only K1 and MK-7 concentrations but also age were independently correlated with ucOC concentration and the ratio of ucOC to iOC. The plasma K1 or MK-7 concentration required to minimize the ucOC concentration was highest in the group aged > or =70 y, and it decreased progressively for each of the younger age groups. CONCLUSIONS: The definite role of ucOC remains unclear. However, if submaximal gamma-carboxylation is related to the prevention of fracture or bone mineral loss, circulating vitamin K concentrations in elderly people should be kept higher than those in young people. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16469998/Vitamin_K_status_of_healthy_Japanese_women:_age_related_vitamin_K_requirement_for_gamma_carboxylation_of_osteocalcin_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/83.2.380 DB - PRIME DP - Unbound Medicine ER -