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The use of fluoroquinolones in children.
Curr Opin Pediatr. 2006 Feb; 18(1):64-70.CO

Abstract

PURPOSE OF REVIEW

The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. Their use in children is limited as a result of possible fluoroquinolone-induced joint/cartilage toxicity observed mainly in juvenile animal studies.

RECENT FINDINGS

Fluoroquinolones were successfully used in immunocompromised children and also in those suffering from multidrug-resistant Gram-negative infections (including neonatal infections and multidrug-resistant enteric infections caused by Salmonella and Shigella spp.). The fluoroquinolones were shown to be efficacious and well tolerated in the treatment of complicated cases of acute otitis media. The emergence of Streptococcus pneumoniae with reduced susceptibility to fluoroquinolones has been described worldwide. No arthropathy associated with fluoroquinolone use in children was evident.

SUMMARY

With the exception of cystic fibrosis and life-endangering infections, the use of fluoroquinolones in pediatrics should be limited to Gram-negative neonatal meningitis, Salmonella and Shigella spp. infections, chronic suppurative otitis media and some cases of complicated acute otitis media. Unskilled use of fluoroquinolones in children, particularly in community-acquired lower respiratory infections, could accelerate the emergence of pneumococcal resistance.

Authors+Show Affiliations

Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. eugenel@bgumail.bgu.ac.il

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16470165

Citation

Leibovitz, Eugene. "The Use of Fluoroquinolones in Children." Current Opinion in Pediatrics, vol. 18, no. 1, 2006, pp. 64-70.
Leibovitz E. The use of fluoroquinolones in children. Curr Opin Pediatr. 2006;18(1):64-70.
Leibovitz, E. (2006). The use of fluoroquinolones in children. Current Opinion in Pediatrics, 18(1), 64-70.
Leibovitz E. The Use of Fluoroquinolones in Children. Curr Opin Pediatr. 2006;18(1):64-70. PubMed PMID: 16470165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of fluoroquinolones in children. A1 - Leibovitz,Eugene, PY - 2006/2/14/pubmed PY - 2006/6/1/medline PY - 2006/2/14/entrez SP - 64 EP - 70 JF - Current opinion in pediatrics JO - Curr Opin Pediatr VL - 18 IS - 1 N2 - PURPOSE OF REVIEW: The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. Their use in children is limited as a result of possible fluoroquinolone-induced joint/cartilage toxicity observed mainly in juvenile animal studies. RECENT FINDINGS: Fluoroquinolones were successfully used in immunocompromised children and also in those suffering from multidrug-resistant Gram-negative infections (including neonatal infections and multidrug-resistant enteric infections caused by Salmonella and Shigella spp.). The fluoroquinolones were shown to be efficacious and well tolerated in the treatment of complicated cases of acute otitis media. The emergence of Streptococcus pneumoniae with reduced susceptibility to fluoroquinolones has been described worldwide. No arthropathy associated with fluoroquinolone use in children was evident. SUMMARY: With the exception of cystic fibrosis and life-endangering infections, the use of fluoroquinolones in pediatrics should be limited to Gram-negative neonatal meningitis, Salmonella and Shigella spp. infections, chronic suppurative otitis media and some cases of complicated acute otitis media. Unskilled use of fluoroquinolones in children, particularly in community-acquired lower respiratory infections, could accelerate the emergence of pneumococcal resistance. SN - 1040-8703 UR - https://www.unboundmedicine.com/medline/citation/16470165/The_use_of_fluoroquinolones_in_children_ L2 - https://doi.org/10.1097/01.mop.0000192520.48411.fa DB - PRIME DP - Unbound Medicine ER -