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Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study.
BMC Public Health 2006; 6:29BP

Abstract

BACKGROUND

Elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of the inadequate vitamin B12 and folate insufficiency. Folate and vitamin B12 have a protective effect on cardiovascular disease. This population based study was conducted to evaluate the plasma total homocysteine, folate, and vitamin B12 in healthy Iranian individuals.

METHODS

This study was a part of the Cardiovascular Risk Factors Survey in the Population Lab Region of Tehran University has been designed and conducted based on the methodology of MONICA/WHO Project. A total of 1214 people aged 25-64 years, were recruited and assessed regarding demographic characteristics, homocysteine, folate, and vitamin B12 levels with interview, questionnaires, examination and blood sampling. Blood samples were gathered and analyzed according to standard methods.

RESULTS

The variables were assessed in 1214 participants including 428 men (35.3%) and 786 women (64.7%). Age-adjusted prevalence of hyperhomocysteinemia (Hcy > or = 15 micromol/L) was 73.1% in men and 41.07% in women (P < 0.0001). Geometric mean of plasma homocysteine was 19.02 +/- 1.46 micromol/l in men and 14.05 +/- 1.45 micromol/l in women (P < 0.004) which increased by ageing. Age-adjusted prevalence of low serum folate level was 98.67% in men and 97.92% in women. Age-adjusted prevalence of low serum vitamin B12 level was 26.32% in men and 27.2% in women. Correlation coefficients (Pearson's r) between log tHcy and serum folate, and vitamin B12 indicated an inverse correlation (r = -0.27, r = -0.19, P < 0.0001, respectively).

CONCLUSION

These results revealed that the prevalence of hyperhomocysteinemia, low folate and vitamin B12 levels are considerably higher than other communities. Implementation of preventive interventions such as food fortification with folic acid is necessary.

Authors+Show Affiliations

Endocrine and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran. emrc@sina.tums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16472406

Citation

Fakhrzadeh, Hossein, et al. "Total Plasma Homocysteine, Folate, and Vitamin B12 Status in Healthy Iranian Adults: the Tehran Homocysteine Survey (2003-2004)/a Cross-sectional Population Based Study." BMC Public Health, vol. 6, 2006, p. 29.
Fakhrzadeh H, Ghotbi S, Pourebrahim R, et al. Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study. BMC Public Health. 2006;6:29.
Fakhrzadeh, H., Ghotbi, S., Pourebrahim, R., Nouri, M., Heshmat, R., Bandarian, F., ... Larijani, B. (2006). Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study. BMC Public Health, 6, p. 29.
Fakhrzadeh H, et al. Total Plasma Homocysteine, Folate, and Vitamin B12 Status in Healthy Iranian Adults: the Tehran Homocysteine Survey (2003-2004)/a Cross-sectional Population Based Study. BMC Public Health. 2006 Feb 13;6:29. PubMed PMID: 16472406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study. AU - Fakhrzadeh,Hossein, AU - Ghotbi,Sara, AU - Pourebrahim,Rasoul, AU - Nouri,Masoumeh, AU - Heshmat,Ramin, AU - Bandarian,Fatemeh, AU - Shafaee,Alireza, AU - Larijani,Bagher, Y1 - 2006/02/13/ PY - 2004/12/29/received PY - 2006/02/13/accepted PY - 2006/2/14/pubmed PY - 2006/4/6/medline PY - 2006/2/14/entrez SP - 29 EP - 29 JF - BMC public health JO - BMC Public Health VL - 6 N2 - BACKGROUND: Elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of the inadequate vitamin B12 and folate insufficiency. Folate and vitamin B12 have a protective effect on cardiovascular disease. This population based study was conducted to evaluate the plasma total homocysteine, folate, and vitamin B12 in healthy Iranian individuals. METHODS: This study was a part of the Cardiovascular Risk Factors Survey in the Population Lab Region of Tehran University has been designed and conducted based on the methodology of MONICA/WHO Project. A total of 1214 people aged 25-64 years, were recruited and assessed regarding demographic characteristics, homocysteine, folate, and vitamin B12 levels with interview, questionnaires, examination and blood sampling. Blood samples were gathered and analyzed according to standard methods. RESULTS: The variables were assessed in 1214 participants including 428 men (35.3%) and 786 women (64.7%). Age-adjusted prevalence of hyperhomocysteinemia (Hcy > or = 15 micromol/L) was 73.1% in men and 41.07% in women (P < 0.0001). Geometric mean of plasma homocysteine was 19.02 +/- 1.46 micromol/l in men and 14.05 +/- 1.45 micromol/l in women (P < 0.004) which increased by ageing. Age-adjusted prevalence of low serum folate level was 98.67% in men and 97.92% in women. Age-adjusted prevalence of low serum vitamin B12 level was 26.32% in men and 27.2% in women. Correlation coefficients (Pearson's r) between log tHcy and serum folate, and vitamin B12 indicated an inverse correlation (r = -0.27, r = -0.19, P < 0.0001, respectively). CONCLUSION: These results revealed that the prevalence of hyperhomocysteinemia, low folate and vitamin B12 levels are considerably higher than other communities. Implementation of preventive interventions such as food fortification with folic acid is necessary. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/16472406/Total_plasma_homocysteine_folate_and_vitamin_B12_status_in_healthy_Iranian_adults:_the_Tehran_homocysteine_survey__2003_2004_/a_cross_sectional_population_based_study_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-6-29 DB - PRIME DP - Unbound Medicine ER -