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Causes and management of intestinal failure in children.
Gastroenterology. 2006 Feb; 130(2 Suppl 1):S16-28.G

Abstract

Intestinal failure is a condition requiring the use of parenteral nutrition as long as it persists. Causes of severe protracted intestinal failure include short bowel syndrome, congenital diseases of enterocyte development, and severe motility disorders (total or subtotal aganglionosis or chronic intestinal pseudo-obstruction syndrome). Intestinal failure may be irreversible in some patients, thus requiring permanent parenteral nutrition. Liver disease may develop with subsequent end-stage liver cirrhosis in patients with intestinal failure as a consequence of both underlying digestive disease and unadapted parenteral nutrition. Death will occur if combined liver-intestine transplantation is not performed. Catheter-related sepsis and/or extensive vascular thrombosis may impede the continuation of a safe and efficient parenteral nutrition and may also require intestinal transplantation in some selected cases. Thus management of patients with intestinal failure requires an early recognition of the condition and the analysis of its risk of irreversibility. Timing of referral for intestinal transplantation remains a crucial issue. As a consequence, management should include therapies adapted to each stage of intestinal failure based on a multidisciplinary approach in centers involving pediatric gastroenterology, parenteral nutrition expertise, home parenteral nutrition program, pediatric surgery, and liver intestinal transplantation program.

Authors+Show Affiliations

Integrated Program of Intestinal Failure, Home Parenteral Nutrition and Intestinal Transplantation, National Reference Center for Rare Digestive Disease, Hôpital Necker-Enfants Malades, Université Reni Descartes, Paris, France. olivier.goulet@nck.aphp.frNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16473066

Citation

Goulet, Olivier, and Frank Ruemmele. "Causes and Management of Intestinal Failure in Children." Gastroenterology, vol. 130, no. 2 Suppl 1, 2006, pp. S16-28.
Goulet O, Ruemmele F. Causes and management of intestinal failure in children. Gastroenterology. 2006;130(2 Suppl 1):S16-28.
Goulet, O., & Ruemmele, F. (2006). Causes and management of intestinal failure in children. Gastroenterology, 130(2 Suppl 1), S16-28.
Goulet O, Ruemmele F. Causes and Management of Intestinal Failure in Children. Gastroenterology. 2006;130(2 Suppl 1):S16-28. PubMed PMID: 16473066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Causes and management of intestinal failure in children. AU - Goulet,Olivier, AU - Ruemmele,Frank, PY - 2004/07/27/received PY - 2005/06/06/accepted PY - 2006/2/14/pubmed PY - 2006/3/31/medline PY - 2006/2/14/entrez SP - S16 EP - 28 JF - Gastroenterology JO - Gastroenterology VL - 130 IS - 2 Suppl 1 N2 - Intestinal failure is a condition requiring the use of parenteral nutrition as long as it persists. Causes of severe protracted intestinal failure include short bowel syndrome, congenital diseases of enterocyte development, and severe motility disorders (total or subtotal aganglionosis or chronic intestinal pseudo-obstruction syndrome). Intestinal failure may be irreversible in some patients, thus requiring permanent parenteral nutrition. Liver disease may develop with subsequent end-stage liver cirrhosis in patients with intestinal failure as a consequence of both underlying digestive disease and unadapted parenteral nutrition. Death will occur if combined liver-intestine transplantation is not performed. Catheter-related sepsis and/or extensive vascular thrombosis may impede the continuation of a safe and efficient parenteral nutrition and may also require intestinal transplantation in some selected cases. Thus management of patients with intestinal failure requires an early recognition of the condition and the analysis of its risk of irreversibility. Timing of referral for intestinal transplantation remains a crucial issue. As a consequence, management should include therapies adapted to each stage of intestinal failure based on a multidisciplinary approach in centers involving pediatric gastroenterology, parenteral nutrition expertise, home parenteral nutrition program, pediatric surgery, and liver intestinal transplantation program. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/16473066/Causes_and_management_of_intestinal_failure_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(05)02410-8 DB - PRIME DP - Unbound Medicine ER -