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Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control.
Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2845-50.PN

Abstract

Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity.

Authors+Show Affiliations

Joint Influenza Research Centre (Shantou University Medical College and Hong Kong University), Shantou, Guangdong 515031, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16473931

Citation

Chen, H, et al. "Establishment of Multiple Sublineages of H5N1 Influenza Virus in Asia: Implications for Pandemic Control." Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 8, 2006, pp. 2845-50.
Chen H, Smith GJ, Li KS, et al. Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci USA. 2006;103(8):2845-50.
Chen, H., Smith, G. J., Li, K. S., Wang, J., Fan, X. H., Rayner, J. M., Vijaykrishna, D., Zhang, J. X., Zhang, L. J., Guo, C. T., Cheung, C. L., Xu, K. M., Duan, L., Huang, K., Qin, K., Leung, Y. H., Wu, W. L., Lu, H. R., Chen, Y., ... Guan, Y. (2006). Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proceedings of the National Academy of Sciences of the United States of America, 103(8), 2845-50.
Chen H, et al. Establishment of Multiple Sublineages of H5N1 Influenza Virus in Asia: Implications for Pandemic Control. Proc Natl Acad Sci USA. 2006 Feb 21;103(8):2845-50. PubMed PMID: 16473931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. AU - Chen,H, AU - Smith,G J D, AU - Li,K S, AU - Wang,J, AU - Fan,X H, AU - Rayner,J M, AU - Vijaykrishna,D, AU - Zhang,J X, AU - Zhang,L J, AU - Guo,C T, AU - Cheung,C L, AU - Xu,K M, AU - Duan,L, AU - Huang,K, AU - Qin,K, AU - Leung,Y H C, AU - Wu,W L, AU - Lu,H R, AU - Chen,Y, AU - Xia,N S, AU - Naipospos,T S P, AU - Yuen,K Y, AU - Hassan,S S, AU - Bahri,S, AU - Nguyen,T D, AU - Webster,R G, AU - Peiris,J S M, AU - Guan,Y, Y1 - 2006/02/10/ PY - 2006/2/14/pubmed PY - 2006/6/14/medline PY - 2006/2/14/entrez SP - 2845 EP - 50 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 103 IS - 8 N2 - Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/16473931/Establishment_of_multiple_sublineages_of_H5N1_influenza_virus_in_Asia:_implications_for_pandemic_control_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16473931 DB - PRIME DP - Unbound Medicine ER -