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Epidemiological, biological and histological characterization of patients with indeterminate third-generation recombinant immunoblot assay antibody results for hepatitis C virus.
J Viral Hepat 2006; 13(3):177-81JV

Abstract

We studied the epidemiological, laboratory and histological characteristics of a group of patients with positive antibodies against hepatitis C virus (HCV) as determined by third-generation enzyme-linked immunosorbent assay (ELISA), and with indeterminate HCV antibody positivity as established by third-generation recombinant immunoblot assay (RIBA-3). The results obtained were compared with those recorded in a group of RIBA-3-positive patients. Both groups correspond to blood donors in whom the prevalence of hepatitis C is low. There were no statistically significant intergroup differences in mean age, or in the presence of infection risk factors. RNA positivity was much more frequent in the RIBA-positive group (71%vs 10%; P < 0.05), as was transaminase elevation during the 3 years of follow-up (54%vs 13%; P < 0.05). In 46% of the RIBA-indeterminate patients the liver biopsy proved normal, or only liver steatosis or minimal changes were detected, while 33% had persistent chronic hepatitis, and 21% showed active chronic hepatitis. A mean Knodell index score of 2.28 was recorded; 50% of the subjects showed no fibrosis, 46% grade 1 fibrosis (fibrous portal expansion), 4% grade 2 fibrosis (bridging fibrosis), and none grade 3 fibrosis (liver cirrhosis). In the RIBA-positive group, a greater percentage of patients had active chronic hepatitis, a greater Knodell index, and increased-grade fibrosis. It can be concluded that the RIBA-3-indeterminate group is epidemiologically similar to the RIBA-3-positive series, although with a lesser prevalence of laboratory test alterations, a lower viral replication index, and more likely to have benign disease - particularly in subjects without viral replication.

Authors+Show Affiliations

Hepatology Section, Service of Digestive Diseases, University General Hospital, Valencia, Spain. mriosp@mixmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16475993

Citation

Ríos, M, et al. "Epidemiological, Biological and Histological Characterization of Patients With Indeterminate Third-generation Recombinant Immunoblot Assay Antibody Results for Hepatitis C Virus." Journal of Viral Hepatitis, vol. 13, no. 3, 2006, pp. 177-81.
Ríos M, Diago M, Rivera P, et al. Epidemiological, biological and histological characterization of patients with indeterminate third-generation recombinant immunoblot assay antibody results for hepatitis C virus. J Viral Hepat. 2006;13(3):177-81.
Ríos, M., Diago, M., Rivera, P., Tuset, C., Cors, R., García, V., ... Gonzalez, C. (2006). Epidemiological, biological and histological characterization of patients with indeterminate third-generation recombinant immunoblot assay antibody results for hepatitis C virus. Journal of Viral Hepatitis, 13(3), pp. 177-81.
Ríos M, et al. Epidemiological, Biological and Histological Characterization of Patients With Indeterminate Third-generation Recombinant Immunoblot Assay Antibody Results for Hepatitis C Virus. J Viral Hepat. 2006;13(3):177-81. PubMed PMID: 16475993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological, biological and histological characterization of patients with indeterminate third-generation recombinant immunoblot assay antibody results for hepatitis C virus. AU - Ríos,M, AU - Diago,M, AU - Rivera,P, AU - Tuset,C, AU - Cors,R, AU - García,V, AU - Carbonel,P, AU - Gonzalez,C, PY - 2006/2/16/pubmed PY - 2006/8/1/medline PY - 2006/2/16/entrez SP - 177 EP - 81 JF - Journal of viral hepatitis JO - J. Viral Hepat. VL - 13 IS - 3 N2 - We studied the epidemiological, laboratory and histological characteristics of a group of patients with positive antibodies against hepatitis C virus (HCV) as determined by third-generation enzyme-linked immunosorbent assay (ELISA), and with indeterminate HCV antibody positivity as established by third-generation recombinant immunoblot assay (RIBA-3). The results obtained were compared with those recorded in a group of RIBA-3-positive patients. Both groups correspond to blood donors in whom the prevalence of hepatitis C is low. There were no statistically significant intergroup differences in mean age, or in the presence of infection risk factors. RNA positivity was much more frequent in the RIBA-positive group (71%vs 10%; P < 0.05), as was transaminase elevation during the 3 years of follow-up (54%vs 13%; P < 0.05). In 46% of the RIBA-indeterminate patients the liver biopsy proved normal, or only liver steatosis or minimal changes were detected, while 33% had persistent chronic hepatitis, and 21% showed active chronic hepatitis. A mean Knodell index score of 2.28 was recorded; 50% of the subjects showed no fibrosis, 46% grade 1 fibrosis (fibrous portal expansion), 4% grade 2 fibrosis (bridging fibrosis), and none grade 3 fibrosis (liver cirrhosis). In the RIBA-positive group, a greater percentage of patients had active chronic hepatitis, a greater Knodell index, and increased-grade fibrosis. It can be concluded that the RIBA-3-indeterminate group is epidemiologically similar to the RIBA-3-positive series, although with a lesser prevalence of laboratory test alterations, a lower viral replication index, and more likely to have benign disease - particularly in subjects without viral replication. SN - 1352-0504 UR - https://www.unboundmedicine.com/medline/citation/16475993/Epidemiological_biological_and_histological_characterization_of_patients_with_indeterminate_third_generation_recombinant_immunoblot_assay_antibody_results_for_hepatitis_C_virus_ L2 - https://doi.org/10.1111/j.1365-2893.2005.00673.x DB - PRIME DP - Unbound Medicine ER -