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Manifestations of the tongue in Neurofibromatosis type 1.
Oral Dis. 2006 Mar; 12(2):125-9.OD

Abstract

OBJECTIVE

The aim of this study is to analyse alterations of the tongue and the correlation between these lesions and different types of tumor.

SUBJECTS AND METHODS

A total of 258 cases (131 females, 127 males) of neurofibromatosis type 1 were screened between 1994 and 2004 in our Dermatology Department. All patients included in this study have NF1, as defined by the NIH Consensus Conference. Three cases of neurofibromas of the tongue in patients with neurofibromatosis type were reported.

RESULTS

Our patients showed nodular lesions on the tongue, related to neurofibromas in two patients and plexiform neurofibroma in one patient, respectively. Clinical and hystopatological findings were useful in distinguishing between neurofibromas and other soft tissue tumors. An increased prevalence of malignancy has been documented in patients affected by neurofibromatosis type 1. Changes in the size of a pre-existing mass, compression, or infiltration of the adjacent structures indicate malignant degeneration. Histological and clinical evaluation should be performed in order to choose the most appropriate treatment strategy for these patients.

CONCLUSION

The oral manifestations of NF are well-documented but may not be at the forefront of the clinician's mind in the differential diagnosis of intra-oral swellings.

Authors+Show Affiliations

Department of Dermatology, University of Palermo, Palermo, Sicily, Italy. istderm@unipa.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16476032

Citation

Bongiorno, M R., et al. "Manifestations of the Tongue in Neurofibromatosis Type 1." Oral Diseases, vol. 12, no. 2, 2006, pp. 125-9.
Bongiorno MR, Pistone G, Aricò M. Manifestations of the tongue in Neurofibromatosis type 1. Oral Dis. 2006;12(2):125-9.
Bongiorno, M. R., Pistone, G., & Aricò, M. (2006). Manifestations of the tongue in Neurofibromatosis type 1. Oral Diseases, 12(2), 125-9.
Bongiorno MR, Pistone G, Aricò M. Manifestations of the Tongue in Neurofibromatosis Type 1. Oral Dis. 2006;12(2):125-9. PubMed PMID: 16476032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Manifestations of the tongue in Neurofibromatosis type 1. AU - Bongiorno,M R, AU - Pistone,G, AU - Aricò,M, PY - 2006/2/16/pubmed PY - 2006/4/21/medline PY - 2006/2/16/entrez SP - 125 EP - 9 JF - Oral diseases JO - Oral Dis VL - 12 IS - 2 N2 - OBJECTIVE: The aim of this study is to analyse alterations of the tongue and the correlation between these lesions and different types of tumor. SUBJECTS AND METHODS: A total of 258 cases (131 females, 127 males) of neurofibromatosis type 1 were screened between 1994 and 2004 in our Dermatology Department. All patients included in this study have NF1, as defined by the NIH Consensus Conference. Three cases of neurofibromas of the tongue in patients with neurofibromatosis type were reported. RESULTS: Our patients showed nodular lesions on the tongue, related to neurofibromas in two patients and plexiform neurofibroma in one patient, respectively. Clinical and hystopatological findings were useful in distinguishing between neurofibromas and other soft tissue tumors. An increased prevalence of malignancy has been documented in patients affected by neurofibromatosis type 1. Changes in the size of a pre-existing mass, compression, or infiltration of the adjacent structures indicate malignant degeneration. Histological and clinical evaluation should be performed in order to choose the most appropriate treatment strategy for these patients. CONCLUSION: The oral manifestations of NF are well-documented but may not be at the forefront of the clinician's mind in the differential diagnosis of intra-oral swellings. SN - 1354-523X UR - https://www.unboundmedicine.com/medline/citation/16476032/Manifestations_of_the_tongue_in_Neurofibromatosis_type_1_ L2 - https://doi.org/10.1111/j.1601-0825.2005.01168.x DB - PRIME DP - Unbound Medicine ER -