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Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1.
Arch Intern Med 2006; 166(3):350-6AI

Abstract

BACKGROUND

Adipose tissue produces "adipocytokines" of uncertain clinical significance.

METHODS

We analyzed the relationships among adiposity, adipocytokines, glycemia, and incident diabetes mellitus in 2356 white and black adults aged 70 to 79 years in the Health, Aging, and Body Composition Study who did not have diabetes at baseline. We measured the levels of adipocytokines adiponectin, leptin, interleukin 6, tumor necrosis factor alpha, and plasminogen activator inhibitor 1. Regional fat area was determined by means of computed tomography. New diabetes was defined as a self-reported diagnosis of diabetes or as a fasting plasma glucose level of 126 mg/dL or greater (>/=7.0 mmol/L) at the second, fourth, or sixth annual examination.

RESULTS

A total of 143 participants (14.1 cases per 1000 person-years) developed diabetes across 5 years. Visceral fat area (odds ratio [OR], 1.33; 95% confidence interval [CI], 1.10-1.60 per standard deviation increase) and body mass index (white individuals: OR, 1.65; 95% CI, 1.26-2.15 per standard deviation increase; black individuals: OR, 1.22; 95% CI, 0.99-1.51 per standard deviation increase) independently predicted incident diabetes. Adiponectin, leptin, and plasminogen activator inhibitor 1 attenuated the relationship between adiposity and diabetes. After controlling for body mass index, visceral fat, fasting glucose, fasting insulin, high-density lipoprotein cholesterol, triglycerides, and hypertension at baseline, plasminogen activator inhibitor 1 was the only adipocytokine independently associated with increased odds of diabetes (OR, 1.35; 95% CI, 1.01-1.81). Fasting glucose level at baseline remained a strong predictor of incident diabetes, whereas associations with body mass index and visceral fat were attenuated.

CONCLUSIONS

Adipocytokines and glycemia partially account for the relationship between adiposity and risk of type 2 diabetes due to adiposity. Plasminogen activator inhibitor 1 may be a useful predictor of diabetes in addition to measurements of body fat.

Authors+Show Affiliations

Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, Suite 500, San Francisco, CA 94143-1732, USA. Alka.Kanaya@ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16476877

Citation

Kanaya, Alka M., et al. "Adipocytokines and Incident Diabetes Mellitus in Older Adults: the Independent Effect of Plasminogen Activator Inhibitor 1." Archives of Internal Medicine, vol. 166, no. 3, 2006, pp. 350-6.
Kanaya AM, Wassel Fyr C, Vittinghoff E, et al. Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. Arch Intern Med. 2006;166(3):350-6.
Kanaya, A. M., Wassel Fyr, C., Vittinghoff, E., Harris, T. B., Park, S. W., Goodpaster, B. H., ... Cummings, S. R. (2006). Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. Archives of Internal Medicine, 166(3), pp. 350-6.
Kanaya AM, et al. Adipocytokines and Incident Diabetes Mellitus in Older Adults: the Independent Effect of Plasminogen Activator Inhibitor 1. Arch Intern Med. 2006 Feb 13;166(3):350-6. PubMed PMID: 16476877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. AU - Kanaya,Alka M, AU - Wassel Fyr,Christina, AU - Vittinghoff,Eric, AU - Harris,Tamara B, AU - Park,Seok Won, AU - Goodpaster,Bret H, AU - Tylavsky,Fran, AU - Cummings,Steven R, PY - 2006/2/16/pubmed PY - 2006/4/21/medline PY - 2006/2/16/entrez SP - 350 EP - 6 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 166 IS - 3 N2 - BACKGROUND: Adipose tissue produces "adipocytokines" of uncertain clinical significance. METHODS: We analyzed the relationships among adiposity, adipocytokines, glycemia, and incident diabetes mellitus in 2356 white and black adults aged 70 to 79 years in the Health, Aging, and Body Composition Study who did not have diabetes at baseline. We measured the levels of adipocytokines adiponectin, leptin, interleukin 6, tumor necrosis factor alpha, and plasminogen activator inhibitor 1. Regional fat area was determined by means of computed tomography. New diabetes was defined as a self-reported diagnosis of diabetes or as a fasting plasma glucose level of 126 mg/dL or greater (>/=7.0 mmol/L) at the second, fourth, or sixth annual examination. RESULTS: A total of 143 participants (14.1 cases per 1000 person-years) developed diabetes across 5 years. Visceral fat area (odds ratio [OR], 1.33; 95% confidence interval [CI], 1.10-1.60 per standard deviation increase) and body mass index (white individuals: OR, 1.65; 95% CI, 1.26-2.15 per standard deviation increase; black individuals: OR, 1.22; 95% CI, 0.99-1.51 per standard deviation increase) independently predicted incident diabetes. Adiponectin, leptin, and plasminogen activator inhibitor 1 attenuated the relationship between adiposity and diabetes. After controlling for body mass index, visceral fat, fasting glucose, fasting insulin, high-density lipoprotein cholesterol, triglycerides, and hypertension at baseline, plasminogen activator inhibitor 1 was the only adipocytokine independently associated with increased odds of diabetes (OR, 1.35; 95% CI, 1.01-1.81). Fasting glucose level at baseline remained a strong predictor of incident diabetes, whereas associations with body mass index and visceral fat were attenuated. CONCLUSIONS: Adipocytokines and glycemia partially account for the relationship between adiposity and risk of type 2 diabetes due to adiposity. Plasminogen activator inhibitor 1 may be a useful predictor of diabetes in addition to measurements of body fat. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/16476877/Adipocytokines_and_incident_diabetes_mellitus_in_older_adults:_the_independent_effect_of_plasminogen_activator_inhibitor_1_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.166.3.350 DB - PRIME DP - Unbound Medicine ER -