Tags

Type your tag names separated by a space and hit enter

Resting energy expenditure and fuel metabolism following laparoscopic adjustable gastric banding in severely obese women: relationships with excess weight lost.

Abstract

BACKGROUND

Although adjustable gastric banding is increasingly proposed for massively obese patients, little is known about the modifications of resting metabolic rate and substrate oxidation or about metabolic determinants of weight loss following this type of bariatric surgery.

OBJECTIVES

To evaluate the relationships between excess weight loss, resting metabolic rate (RMR) and substrate oxidation, and to identify metabolic predictive factors of weight loss after adjustable gastric banding.

SUBJECTS

Seventy-three obese nondiabetic women aged 39.1+/-10.4 years (18.4-64.8).

DESIGN

Resting metabolic rate and substrate oxidation (indirect calorimetry), body composition (bio-impedance), lipid profile and insulin sensitivity indexes were assessed before and after (13.3+/-6.0 months, range 6.0-31.1) adjustable gastric banding. Patients were classified according to postsurgery time: group A (6-12 months, n=39); group B (12-18 months, n=21); group C (>18 months, n=13). Metabolic parameters associated with the percentage of excess weight lost (EWL) 1 year after surgery were analyzed in univariate and multivariate regressions.

RESULTS

Mean weight loss was 26.2+/-11.4 kg. Mean fat mass loss was 17.3+/-8.1 kg. All biological parameters associated with excess weight improved after surgery. Excess weight lost at 1 year was 45.9+/-17.1% in group A, 47.4+/-17.1% in group B and 51.4+/-18.5% in group C (P=NS). Resting metabolic rate/fat-free mass (FFM) slightly decreased (28.9+/-3.26 vs 30.3+/-2.8, P<0.00001) and RMR/body weight slightly increased (18.5+/-2.8 vs 17.3+/-1.9, P<0.00001) after surgery. Respiratory quotient (0.81+/-0.06 vs 0.82+/-0.05) and FFM-adjusted lipid oxidation (1.10+/-0.41 vs 1.05+/-0.33 mg/min/kg FFM) were not significantly modified after surgery. In multiple linear regression analysis, difference in RMR/body weight, difference in energy sparing, baseline BMI and postsurgery time, were significantly and independently correlated with EWL (total R2=72.5%).

CONCLUSIONS

Adjustable gastric banding promotes gradual but sustained weight loss and is associated with long-term conservation of lipid oxidation and energy expenditure. The individual variability in energy sparing mechanisms predicts weight loss during the first year after surgery.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centre d'Investigation Clinique, Hôpital St Eloi, Montpellier Cedex, France. f-galtier@chu-montpellier.fr

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Anthropometry
    Basal Metabolism
    Body Composition
    Calorimetry, Indirect
    Energy Metabolism
    Female
    Follow-Up Studies
    Gastroplasty
    Humans
    Lipid Metabolism
    Middle Aged
    Obesity, Morbid
    Oxidation-Reduction
    Postoperative Period
    Prognosis
    Treatment Outcome
    Weight Loss

    Pub Type(s)

    Evaluation Studies
    Journal Article

    Language

    eng

    PubMed ID

    16477271

    Citation

    Galtier, F, et al. "Resting Energy Expenditure and Fuel Metabolism Following Laparoscopic Adjustable Gastric Banding in Severely Obese Women: Relationships With Excess Weight Lost." International Journal of Obesity (2005), vol. 30, no. 7, 2006, pp. 1104-10.
    Galtier F, Farret A, Verdier R, et al. Resting energy expenditure and fuel metabolism following laparoscopic adjustable gastric banding in severely obese women: relationships with excess weight lost. Int J Obes (Lond). 2006;30(7):1104-10.
    Galtier, F., Farret, A., Verdier, R., Barbotte, E., Nocca, D., Fabre, J. M., ... Renard, E. (2006). Resting energy expenditure and fuel metabolism following laparoscopic adjustable gastric banding in severely obese women: relationships with excess weight lost. International Journal of Obesity (2005), 30(7), pp. 1104-10.
    Galtier F, et al. Resting Energy Expenditure and Fuel Metabolism Following Laparoscopic Adjustable Gastric Banding in Severely Obese Women: Relationships With Excess Weight Lost. Int J Obes (Lond). 2006;30(7):1104-10. PubMed PMID: 16477271.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Resting energy expenditure and fuel metabolism following laparoscopic adjustable gastric banding in severely obese women: relationships with excess weight lost. AU - Galtier,F, AU - Farret,A, AU - Verdier,R, AU - Barbotte,E, AU - Nocca,D, AU - Fabre,J-M, AU - Bringer,J, AU - Renard,E, Y1 - 2006/02/14/ PY - 2006/2/16/pubmed PY - 2007/3/1/medline PY - 2006/2/16/entrez SP - 1104 EP - 10 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 7 N2 - BACKGROUND: Although adjustable gastric banding is increasingly proposed for massively obese patients, little is known about the modifications of resting metabolic rate and substrate oxidation or about metabolic determinants of weight loss following this type of bariatric surgery. OBJECTIVES: To evaluate the relationships between excess weight loss, resting metabolic rate (RMR) and substrate oxidation, and to identify metabolic predictive factors of weight loss after adjustable gastric banding. SUBJECTS: Seventy-three obese nondiabetic women aged 39.1+/-10.4 years (18.4-64.8). DESIGN: Resting metabolic rate and substrate oxidation (indirect calorimetry), body composition (bio-impedance), lipid profile and insulin sensitivity indexes were assessed before and after (13.3+/-6.0 months, range 6.0-31.1) adjustable gastric banding. Patients were classified according to postsurgery time: group A (6-12 months, n=39); group B (12-18 months, n=21); group C (>18 months, n=13). Metabolic parameters associated with the percentage of excess weight lost (EWL) 1 year after surgery were analyzed in univariate and multivariate regressions. RESULTS: Mean weight loss was 26.2+/-11.4 kg. Mean fat mass loss was 17.3+/-8.1 kg. All biological parameters associated with excess weight improved after surgery. Excess weight lost at 1 year was 45.9+/-17.1% in group A, 47.4+/-17.1% in group B and 51.4+/-18.5% in group C (P=NS). Resting metabolic rate/fat-free mass (FFM) slightly decreased (28.9+/-3.26 vs 30.3+/-2.8, P<0.00001) and RMR/body weight slightly increased (18.5+/-2.8 vs 17.3+/-1.9, P<0.00001) after surgery. Respiratory quotient (0.81+/-0.06 vs 0.82+/-0.05) and FFM-adjusted lipid oxidation (1.10+/-0.41 vs 1.05+/-0.33 mg/min/kg FFM) were not significantly modified after surgery. In multiple linear regression analysis, difference in RMR/body weight, difference in energy sparing, baseline BMI and postsurgery time, were significantly and independently correlated with EWL (total R2=72.5%). CONCLUSIONS: Adjustable gastric banding promotes gradual but sustained weight loss and is associated with long-term conservation of lipid oxidation and energy expenditure. The individual variability in energy sparing mechanisms predicts weight loss during the first year after surgery. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16477271/Resting_energy_expenditure_and_fuel_metabolism_following_laparoscopic_adjustable_gastric_banding_in_severely_obese_women:_relationships_with_excess_weight_lost_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803247 DB - PRIME DP - Unbound Medicine ER -