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Orthostatic hypotension as an early finding in Parkinson's disease.
Clin Auton Res. 2006 Feb; 16(1):46-54.CA

Abstract

Patients with Parkinson's disease (PD) commonly have clinically significant orthostatic hypotension (OH). In such patients PD+OH might be confused with multiple system atrophy (MSA), in which OH is a frequent finding, or with pure autonomic failure (PAF), if OH preceded clinical manifestations of the movement disorder. This study addressed whether OH can occur as an early finding in PD+OH. Historical data were analyzed from 35 patients with PD+OH evaluated at the NIH. OH was considered early if the patient had OH before, concurrent with, or starting within 1 year after onset of a symptomatic movement disorder. MSA was excluded by myocardial 6-[(18)F]fluorodopamine-derived radioactivity more than 2 standard deviations below the normal mean. Among the 35 PD+OH patients, 21 (60 %) had documentation of OH as an early finding. In 4 such patients, OH had preceded parkinsonism, and in 4 others, OH had dominated the early clinical picture, even after cessation of levodopa treatment for the movement disorder. In PD, OH can occur early in the disease, occasionally preceding or overshadowing the movement disorder.

Authors+Show Affiliations

Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10/Room 6N252, 10 Center Drive, MSC-1620, Bethesda, MD 20892, USA. goldsteind@ninds.nih.gov

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16477495

Citation

Goldstein, David S.. "Orthostatic Hypotension as an Early Finding in Parkinson's Disease." Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, vol. 16, no. 1, 2006, pp. 46-54.
Goldstein DS. Orthostatic hypotension as an early finding in Parkinson's disease. Clin Auton Res. 2006;16(1):46-54.
Goldstein, D. S. (2006). Orthostatic hypotension as an early finding in Parkinson's disease. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, 16(1), 46-54.
Goldstein DS. Orthostatic Hypotension as an Early Finding in Parkinson's Disease. Clin Auton Res. 2006;16(1):46-54. PubMed PMID: 16477495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orthostatic hypotension as an early finding in Parkinson's disease. A1 - Goldstein,David S, PY - 2005/03/15/received PY - 2005/09/27/accepted PY - 2006/2/16/pubmed PY - 2006/5/10/medline PY - 2006/2/16/entrez SP - 46 EP - 54 JF - Clinical autonomic research : official journal of the Clinical Autonomic Research Society JO - Clin Auton Res VL - 16 IS - 1 N2 - Patients with Parkinson's disease (PD) commonly have clinically significant orthostatic hypotension (OH). In such patients PD+OH might be confused with multiple system atrophy (MSA), in which OH is a frequent finding, or with pure autonomic failure (PAF), if OH preceded clinical manifestations of the movement disorder. This study addressed whether OH can occur as an early finding in PD+OH. Historical data were analyzed from 35 patients with PD+OH evaluated at the NIH. OH was considered early if the patient had OH before, concurrent with, or starting within 1 year after onset of a symptomatic movement disorder. MSA was excluded by myocardial 6-[(18)F]fluorodopamine-derived radioactivity more than 2 standard deviations below the normal mean. Among the 35 PD+OH patients, 21 (60 %) had documentation of OH as an early finding. In 4 such patients, OH had preceded parkinsonism, and in 4 others, OH had dominated the early clinical picture, even after cessation of levodopa treatment for the movement disorder. In PD, OH can occur early in the disease, occasionally preceding or overshadowing the movement disorder. SN - 0959-9851 UR - https://www.unboundmedicine.com/medline/citation/16477495/Orthostatic_hypotension_as_an_early_finding_in_Parkinson's_disease_ L2 - http://dx.doi.org/10.1007/s10286-006-0317-8 DB - PRIME DP - Unbound Medicine ER -