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The validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects.
Int J Geriatr Psychiatry. 2006 Mar; 21(3):259-65.IJ

Abstract

OBJECTIVES

The cognitive subscale of the Alzheimer's Disease Assesment Scale (ADAS-Cog) is the most widely used test in clinical trials dealing with Alzheimer's disease (AD). The aim of this study was to investigate the validity and reliability of the Turkish version of ADAS-Cog.

METHODS

Twenty-nine patients with AD, fulfilling NINCDS-ADRDA criteria of probable AD, who were in stage 3-5 according to the Global Deterioration Scale (GDS), and 27 non-demented control subjects with similar age, gender and educational status were recruited for the study. The Turkish version of ADAS-Cog, Standardized Mini Mental Status Examination (MMSE) and Short Orientation-Memory-Concentration Test (SOMCT) were applied to both of the groups. Inter-rater reliability, internal consistency, test-retest reliability; face validity, differential validity and convergent validity were statistically analyzed.

RESULTS

Both MMSE and ADAS-Cog have significantly differentiated patients with AD and control subjects (p < 0.001). A significant correlation was established between MMSE and ADAS-Cog scores in AD group (r: -0.739). ADAS-Cog was also highly significantly correlated with GDS (r: 0.720) and SOMCT (r: 0.738). For the group with AD, control and whole cohort coefficients of internal consistency, Cronbach's alpha: 0.800, 0.515, 0.873 were found respectively. Inter-rater reliability for total ADAS-Cog score was found as ICC: 0.99 and 0.98 and test-retest reliability was found as ICC: 0.91 and 0.95 for demented and nondemented subjects, respectively.

CONCLUSION

The Turkish version of ADAS-Cog has been found to be highly reliable and valid in differentiating patients with mild and moderate AD from nondemented subjects.

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. hmavioglu@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

16477580

Citation

Mavioglu, H, et al. "The Validity and Reliability of the Turkish Version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in Patients With Mild and Moderate Alzheimer's Disease and Normal Subjects." International Journal of Geriatric Psychiatry, vol. 21, no. 3, 2006, pp. 259-65.
Mavioglu H, Gedizlioglu M, Akyel S, et al. The validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects. Int J Geriatr Psychiatry. 2006;21(3):259-65.
Mavioglu, H., Gedizlioglu, M., Akyel, S., Aslaner, T., & Eser, E. (2006). The validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects. International Journal of Geriatric Psychiatry, 21(3), 259-65.
Mavioglu H, et al. The Validity and Reliability of the Turkish Version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in Patients With Mild and Moderate Alzheimer's Disease and Normal Subjects. Int J Geriatr Psychiatry. 2006;21(3):259-65. PubMed PMID: 16477580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects. AU - Mavioglu,H, AU - Gedizlioglu,M, AU - Akyel,S, AU - Aslaner,T, AU - Eser,E, PY - 2006/2/16/pubmed PY - 2006/11/15/medline PY - 2006/2/16/entrez SP - 259 EP - 65 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 21 IS - 3 N2 - OBJECTIVES: The cognitive subscale of the Alzheimer's Disease Assesment Scale (ADAS-Cog) is the most widely used test in clinical trials dealing with Alzheimer's disease (AD). The aim of this study was to investigate the validity and reliability of the Turkish version of ADAS-Cog. METHODS: Twenty-nine patients with AD, fulfilling NINCDS-ADRDA criteria of probable AD, who were in stage 3-5 according to the Global Deterioration Scale (GDS), and 27 non-demented control subjects with similar age, gender and educational status were recruited for the study. The Turkish version of ADAS-Cog, Standardized Mini Mental Status Examination (MMSE) and Short Orientation-Memory-Concentration Test (SOMCT) were applied to both of the groups. Inter-rater reliability, internal consistency, test-retest reliability; face validity, differential validity and convergent validity were statistically analyzed. RESULTS: Both MMSE and ADAS-Cog have significantly differentiated patients with AD and control subjects (p < 0.001). A significant correlation was established between MMSE and ADAS-Cog scores in AD group (r: -0.739). ADAS-Cog was also highly significantly correlated with GDS (r: 0.720) and SOMCT (r: 0.738). For the group with AD, control and whole cohort coefficients of internal consistency, Cronbach's alpha: 0.800, 0.515, 0.873 were found respectively. Inter-rater reliability for total ADAS-Cog score was found as ICC: 0.99 and 0.98 and test-retest reliability was found as ICC: 0.91 and 0.95 for demented and nondemented subjects, respectively. CONCLUSION: The Turkish version of ADAS-Cog has been found to be highly reliable and valid in differentiating patients with mild and moderate AD from nondemented subjects. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/16477580/The_validity_and_reliability_of_the_Turkish_version_of_Alzheimer's_Disease_Assessment_Scale_Cognitive_Subscale__ADAS_Cog__in_patients_with_mild_and_moderate_Alzheimer's_disease_and_normal_subjects_ L2 - https://doi.org/10.1002/gps.1457 DB - PRIME DP - Unbound Medicine ER -