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Depressive symptom profile in Parkinson's disease: a comparison with depression in elderly patients without Parkinson's disease.
Int J Geriatr Psychiatry. 2006 Mar; 21(3):252-8.IJ

Abstract

OBJECTIVE

Depression is a common neuropsychiatric syndrome in Parkinson's disease (PD), and may be etiologically related to the neurochemical changes accompanying this disease. It is still unclear whether the disturbances of neurotransmitter activities lead to a specific profile of depressive symptoms, that is characteristic for PD and differs from that in depressed patients without PD.

METHOD

We compared the individual depressive symptoms of 145 non-demented depressed patients with PD and 100 depressed patients without PD by comparing item scores on the Montgomery-Asberg Depression Rating Scale by way of MANCOVA.

RESULTS

The severity of depression and the level of cognitive functioning in depressed PD patients were comparable with that of depressed control subjects. However, patients with PD showed significant less reported sadness, less anhedonia, less feelings of guilt and, slightly less loss of energy, but more concentration problems than depressed control subjects.

CONCLUSION

The profile of depressive symptoms in PD differs from that in depressed subjects without PD. This finding is important for the conceptualisation and clinical diagnosis of depression in PD.

Authors+Show Affiliations

Section of Geriatric Psychiatry, Stavanger University Hospital, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16477585

Citation

Ehrt, Uwe, et al. "Depressive Symptom Profile in Parkinson's Disease: a Comparison With Depression in Elderly Patients Without Parkinson's Disease." International Journal of Geriatric Psychiatry, vol. 21, no. 3, 2006, pp. 252-8.
Ehrt U, Brønnick K, Leentjens AF, et al. Depressive symptom profile in Parkinson's disease: a comparison with depression in elderly patients without Parkinson's disease. Int J Geriatr Psychiatry. 2006;21(3):252-8.
Ehrt, U., Brønnick, K., Leentjens, A. F., Larsen, J. P., & Aarsland, D. (2006). Depressive symptom profile in Parkinson's disease: a comparison with depression in elderly patients without Parkinson's disease. International Journal of Geriatric Psychiatry, 21(3), 252-8.
Ehrt U, et al. Depressive Symptom Profile in Parkinson's Disease: a Comparison With Depression in Elderly Patients Without Parkinson's Disease. Int J Geriatr Psychiatry. 2006;21(3):252-8. PubMed PMID: 16477585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptom profile in Parkinson's disease: a comparison with depression in elderly patients without Parkinson's disease. AU - Ehrt,Uwe, AU - Brønnick,Kolbjørn, AU - Leentjens,Albert F G, AU - Larsen,Jan Petter, AU - Aarsland,Dag, PY - 2006/2/16/pubmed PY - 2006/11/15/medline PY - 2006/2/16/entrez SP - 252 EP - 8 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 21 IS - 3 N2 - OBJECTIVE: Depression is a common neuropsychiatric syndrome in Parkinson's disease (PD), and may be etiologically related to the neurochemical changes accompanying this disease. It is still unclear whether the disturbances of neurotransmitter activities lead to a specific profile of depressive symptoms, that is characteristic for PD and differs from that in depressed patients without PD. METHOD: We compared the individual depressive symptoms of 145 non-demented depressed patients with PD and 100 depressed patients without PD by comparing item scores on the Montgomery-Asberg Depression Rating Scale by way of MANCOVA. RESULTS: The severity of depression and the level of cognitive functioning in depressed PD patients were comparable with that of depressed control subjects. However, patients with PD showed significant less reported sadness, less anhedonia, less feelings of guilt and, slightly less loss of energy, but more concentration problems than depressed control subjects. CONCLUSION: The profile of depressive symptoms in PD differs from that in depressed subjects without PD. This finding is important for the conceptualisation and clinical diagnosis of depression in PD. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/16477585/Depressive_symptom_profile_in_Parkinson's_disease:_a_comparison_with_depression_in_elderly_patients_without_Parkinson's_disease_ L2 - https://doi.org/10.1002/gps.1456 DB - PRIME DP - Unbound Medicine ER -